Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313893404> ?p ?o ?g. }
- W4313893404 endingPage "121385" @default.
- W4313893404 startingPage "121385" @default.
- W4313893404 abstract "Cadmium is a hazardous metal with multiple organ toxicity that causes great harm to human health. Cadmium enters the human body through occupational exposure, diet, drinking water, breathing, and smoking. Cadmium accumulation in the human body is associated with increased risk of developing obesity, cardiovascular disease, diabetes, and metabolic syndrome (MetS). Cadmium uptake is enhanced during pregnancy and can cross the placenta affecting placental development and function. Subsequently, cadmium can pass to fetus, gathering in multiple organs such as the liver and pancreas. Early-life cadmium exposure can induce hepatic oxidative stress and pancreatic β-cell dysfunction, resulting in insulin resistance and glucose metabolic dyshomeostasis in the offspring. Prenatal exposure to cadmium is also associated with increasing epigenetic effects on the offspring's multi-organ functions. However, whether and how maternal exposure to low-dose cadmium impacts the risks of developing type 2 diabetes (T2D) in the young and/or adult offspring remains unclear. This review collected available data to address the current evidence for the potential role of cadmium exposure, leading to insulin resistance and the development of T2D in offspring. However, this review reveals that underlying mechanisms linking prenatal cadmium exposure during pregnancy with T2D in offspring remain to be adequately investigated." @default.
- W4313893404 created "2023-01-10" @default.
- W4313893404 creator A5017873319 @default.
- W4313893404 creator A5022407487 @default.
- W4313893404 creator A5027426248 @default.
- W4313893404 creator A5059205796 @default.
- W4313893404 creator A5061379338 @default.
- W4313893404 creator A5068802761 @default.
- W4313893404 date "2023-02-01" @default.
- W4313893404 modified "2023-10-17" @default.
- W4313893404 title "Does maternal low-dose cadmium exposure increase the risk of offspring to develop metabolic syndrome and/or type 2 diabetes?" @default.
- W4313893404 cites W1530992231 @default.
- W4313893404 cites W1665938856 @default.
- W4313893404 cites W1964744590 @default.
- W4313893404 cites W1966169534 @default.
- W4313893404 cites W1969386345 @default.
- W4313893404 cites W1969492071 @default.
- W4313893404 cites W1971029775 @default.
- W4313893404 cites W1976098516 @default.
- W4313893404 cites W1976994568 @default.
- W4313893404 cites W1978681854 @default.
- W4313893404 cites W1981704941 @default.
- W4313893404 cites W1982406683 @default.
- W4313893404 cites W1986310963 @default.
- W4313893404 cites W1993640667 @default.
- W4313893404 cites W1995106205 @default.
- W4313893404 cites W1997843365 @default.
- W4313893404 cites W2000518233 @default.
- W4313893404 cites W2003967113 @default.
- W4313893404 cites W2006872703 @default.
- W4313893404 cites W2007431652 @default.
- W4313893404 cites W2008045273 @default.
- W4313893404 cites W2012674858 @default.
- W4313893404 cites W2017924999 @default.
- W4313893404 cites W2019517142 @default.
- W4313893404 cites W2024140290 @default.
- W4313893404 cites W2027991560 @default.
- W4313893404 cites W2033447919 @default.
- W4313893404 cites W2035646363 @default.
- W4313893404 cites W2038073692 @default.
- W4313893404 cites W2042377388 @default.
- W4313893404 cites W2044002866 @default.
- W4313893404 cites W2045573287 @default.
- W4313893404 cites W2046678424 @default.
- W4313893404 cites W2048308534 @default.
- W4313893404 cites W2049271271 @default.
- W4313893404 cites W2051759480 @default.
- W4313893404 cites W2059240811 @default.
- W4313893404 cites W2060195097 @default.
- W4313893404 cites W2060568888 @default.
- W4313893404 cites W2065258985 @default.
- W4313893404 cites W2071149490 @default.
- W4313893404 cites W2071764836 @default.
- W4313893404 cites W2077065305 @default.
- W4313893404 cites W2086215413 @default.
- W4313893404 cites W2086299843 @default.
- W4313893404 cites W2092670527 @default.
- W4313893404 cites W2103273602 @default.
- W4313893404 cites W2105224907 @default.
- W4313893404 cites W2106681373 @default.
- W4313893404 cites W2109421896 @default.
- W4313893404 cites W2112185825 @default.
- W4313893404 cites W2112668580 @default.
- W4313893404 cites W2122341467 @default.
- W4313893404 cites W2123412097 @default.
- W4313893404 cites W2125863862 @default.
- W4313893404 cites W2126745010 @default.
- W4313893404 cites W2129880677 @default.
- W4313893404 cites W2133208346 @default.
- W4313893404 cites W2136303436 @default.
- W4313893404 cites W2137941279 @default.
- W4313893404 cites W2140456647 @default.
- W4313893404 cites W2143877756 @default.
- W4313893404 cites W2149833807 @default.
- W4313893404 cites W2150165899 @default.
- W4313893404 cites W2152110544 @default.
- W4313893404 cites W2156012627 @default.
- W4313893404 cites W2157655909 @default.
- W4313893404 cites W2166352102 @default.
- W4313893404 cites W2166514049 @default.
- W4313893404 cites W2166954428 @default.
- W4313893404 cites W2168565177 @default.
- W4313893404 cites W2169002310 @default.
- W4313893404 cites W2172219090 @default.
- W4313893404 cites W2234372933 @default.
- W4313893404 cites W2296585153 @default.
- W4313893404 cites W2396611417 @default.
- W4313893404 cites W2433204774 @default.
- W4313893404 cites W2436046942 @default.
- W4313893404 cites W2440896643 @default.
- W4313893404 cites W2492282451 @default.
- W4313893404 cites W2553902009 @default.
- W4313893404 cites W2592930050 @default.
- W4313893404 cites W2620558147 @default.
- W4313893404 cites W2738165969 @default.
- W4313893404 cites W2769900543 @default.
- W4313893404 cites W2772781076 @default.
- W4313893404 cites W2773900422 @default.