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• W4313894046 endingPage "76" @default.
• W4313894046 startingPage "76" @default.
• W4313894046 abstract "Topological rearrangements of biological membranes, such as fusion and fission, often require a sophisticated interplay between different proteins and cellular membranes. However, in the case of fusion proteins of enveloped viruses, even one molecule can execute membrane restructurings. Growing evidence indicates that matrix proteins of enveloped viruses can solely trigger the membrane bending required for another crucial step in virogenesis, the budding of progeny virions. For the case of the influenza A virus matrix protein M1, different studies report both in favor and against M1 being able to produce virus-like particles without other viral proteins. Here, we investigated the physicochemical mechanisms of M1 membrane activity on giant unilamellar vesicles of different lipid compositions using fluorescent confocal microscopy. We confirmed that M1 predominantly interacts electrostatically with the membrane, and its ability to deform the lipid bilayer is non-specific and typical for membrane-binding proteins and polypeptides. However, in the case of phase-separating membranes, M1 demonstrates a unique ability to induce macro-phase separation, probably due to the high affinity of M1's amphipathic helices to the raft boundary. Thus, we suggest that M1 is tailored to deform charged membranes with a specific activity in the case of phase-separating membranes." @default.
• W4313894046 created "2023-01-10" @default.
• W4313894046 creator A5014039039 @default.
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• W4313894046 creator A5089150064 @default.
• W4313894046 date "2023-01-07" @default.
• W4313894046 modified "2023-10-18" @default.
• W4313894046 title "Influenza A Virus M1 Protein Non-Specifically Deforms Charged Lipid Membranes and Specifically Interacts with the Raft Boundary" @default.
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• W4313894046 doi "https://doi.org/10.3390/membranes13010076" @default.
• W4313894046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36676883" @default.
• W4313894046 hasPublicationYear "2023" @default.
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