FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313894212> ?p ?o ?g. }

• W4313894212 abstract "Lupus erythematosus (LE) is an autoimmune inflammatory disease with a wide clinical spectrum from life-threatening multi-organ inflammation in systemic lupus erythematosus (SLE) to limited skin disease in cutaneous LE (CLE). The etiology of CLE is still not fully understood but a multifactorial genesis with genetic predisposition and certain environmental factors as triggers for the development are generally accepted features. Lesions can be induced and aggravated by UV-irradiation and smoking is linked to more severe forms of skin disease and to co-morbidity. Drugs, including many common medicines like antihypertensives, are known to induce subacute CLE (SCLE). The mechanisms involved have recently been shown to be part of the IFN-I pathway and new, specific treatments are currently in clinical trials. CLE is currently classified in subtypes based on clinical presentation and duration into acute CLE (ACLE), SCLE, and chronic CLE (CCLE). Distinct subtypes can be seen in individual patients or coexist within the same patient. Because of the confluent and overlapping picture between these subsets, serology, and histopathology constitute an important role guiding towards correct diagnose and there is ongoing work to update the classification. The Cutaneous Lupus Area Severity Index (CLASI) is a validated tool to measure activity and damage both in clinical trials but also for the clinician to evaluate treatment and follow the course of the disease among patients. CLE is known to have substantial impact on the life of those affected. Several tools have been proposed to measure QoL in these patients, currently Skindex-29 is probably the most used. Patient education is an important part of prevention of flares, including UV-protection and smoking cessation. First-line treatment includes topical corticosteroids as well as topical calcineurin inhibitors with the addition of systemic treatment with antimalarials in more severe or therapy resistant cases. Treatment specifically targeting CLE has been lacking, however novel potential therapies are in later phase clinical trials. In this review we aim to describe the different subsets of the cutaneous form in LE with focus on clinical aspects." @default.
• W4313894212 created "2023-01-10" @default.
• W4313894212 creator A5054650258 @default.
• W4313894212 creator A5061779790 @default.
• W4313894212 date "2023-01-09" @default.
• W4313894212 modified "2023-10-01" @default.
• W4313894212 title "Clinical aspects of cutaneous lupus erythematosus" @default.
• W4313894212 cites W1358789 @default.
• W4313894212 cites W1559866740 @default.
• W4313894212 cites W1571802145 @default.
• W4313894212 cites W1598558267 @default.
• W4313894212 cites W1613576600 @default.
• W4313894212 cites W1745322584 @default.
• W4313894212 cites W1851734173 @default.
• W4313894212 cites W187712674 @default.
• W4313894212 cites W1938675283 @default.
• W4313894212 cites W1975206337 @default.
• W4313894212 cites W1976323831 @default.
• W4313894212 cites W1978169549 @default.
• W4313894212 cites W1978470483 @default.
• W4313894212 cites W1982975365 @default.
• W4313894212 cites W1985581911 @default.
• W4313894212 cites W1989504413 @default.
• W4313894212 cites W1989634593 @default.
• W4313894212 cites W1991978773 @default.
• W4313894212 cites W1994830743 @default.
• W4313894212 cites W1996162902 @default.
• W4313894212 cites W1998691598 @default.
• W4313894212 cites W2009537796 @default.
• W4313894212 cites W2011608050 @default.
• W4313894212 cites W2011784300 @default.
• W4313894212 cites W2013025270 @default.
• W4313894212 cites W2015024672 @default.
• W4313894212 cites W2021794428 @default.
• W4313894212 cites W2031680761 @default.
• W4313894212 cites W2033644580 @default.
• W4313894212 cites W2040657208 @default.
• W4313894212 cites W2045304841 @default.
• W4313894212 cites W2045709463 @default.
• W4313894212 cites W2047342378 @default.
• W4313894212 cites W2049632532 @default.
• W4313894212 cites W2060139354 @default.
• W4313894212 cites W2062944200 @default.
• W4313894212 cites W2070618191 @default.
• W4313894212 cites W2073707507 @default.
• W4313894212 cites W2076493823 @default.
• W4313894212 cites W2081251423 @default.
• W4313894212 cites W2093076036 @default.
• W4313894212 cites W2096991001 @default.
• W4313894212 cites W2104125890 @default.
• W4313894212 cites W2108457947 @default.
• W4313894212 cites W2116749206 @default.
• W4313894212 cites W2117068474 @default.
• W4313894212 cites W2127373003 @default.
• W4313894212 cites W2140225415 @default.
• W4313894212 cites W2146203649 @default.
• W4313894212 cites W2153490933 @default.
• W4313894212 cites W2159860161 @default.
• W4313894212 cites W2183636813 @default.
• W4313894212 cites W2268649073 @default.
• W4313894212 cites W2275754676 @default.
• W4313894212 cites W2278093194 @default.
• W4313894212 cites W2293969694 @default.
• W4313894212 cites W2503904616 @default.
• W4313894212 cites W2513658500 @default.
• W4313894212 cites W2553948261 @default.
• W4313894212 cites W2602281737 @default.
• W4313894212 cites W2621893371 @default.
• W4313894212 cites W2625039393 @default.
• W4313894212 cites W2739854214 @default.
• W4313894212 cites W2766485913 @default.
• W4313894212 cites W2766717190 @default.
• W4313894212 cites W2767342241 @default.
• W4313894212 cites W2800435758 @default.
• W4313894212 cites W2804146934 @default.
• W4313894212 cites W2805138206 @default.
• W4313894212 cites W2806711256 @default.
• W4313894212 cites W2808400414 @default.
• W4313894212 cites W2908749653 @default.
• W4313894212 cites W2922079780 @default.
• W4313894212 cites W2927871970 @default.
• W4313894212 cites W2940853643 @default.
• W4313894212 cites W2975097200 @default.
• W4313894212 cites W2978592583 @default.
• W4313894212 cites W2980196284 @default.
• W4313894212 cites W2990232817 @default.
• W4313894212 cites W2990789404 @default.
• W4313894212 cites W3021821755 @default.
• W4313894212 cites W3036680543 @default.
• W4313894212 cites W3040445112 @default.
• W4313894212 cites W3043946070 @default.
• W4313894212 cites W3047401054 @default.
• W4313894212 cites W3084976623 @default.
• W4313894212 cites W3087103069 @default.
• W4313894212 cites W3090764613 @default.
• W4313894212 cites W3092111592 @default.
• W4313894212 cites W3110946209 @default.
• W4313894212 cites W3111073772 @default.
• W4313894212 cites W3111245311 @default.
• W4313894212 cites W3111249725 @default.

• next