Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313894773> ?p ?o ?g. }
- W4313894773 endingPage "606" @default.
- W4313894773 startingPage "606" @default.
- W4313894773 abstract "Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients." @default.
- W4313894773 created "2023-01-10" @default.
- W4313894773 creator A5000418548 @default.
- W4313894773 creator A5004095815 @default.
- W4313894773 creator A5024507727 @default.
- W4313894773 creator A5027982369 @default.
- W4313894773 creator A5032308726 @default.
- W4313894773 creator A5036415464 @default.
- W4313894773 creator A5040873811 @default.
- W4313894773 creator A5079143892 @default.
- W4313894773 creator A5080702907 @default.
- W4313894773 creator A5080946366 @default.
- W4313894773 creator A5085480749 @default.
- W4313894773 creator A5088778910 @default.
- W4313894773 date "2023-01-06" @default.
- W4313894773 modified "2023-10-01" @default.
- W4313894773 title "Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp." @default.
- W4313894773 cites W1881372541 @default.
- W4313894773 cites W1963534330 @default.
- W4313894773 cites W1977042516 @default.
- W4313894773 cites W1979302769 @default.
- W4313894773 cites W1980543039 @default.
- W4313894773 cites W1981025594 @default.
- W4313894773 cites W1986963843 @default.
- W4313894773 cites W1991109832 @default.
- W4313894773 cites W2001664382 @default.
- W4313894773 cites W2004677265 @default.
- W4313894773 cites W2004680199 @default.
- W4313894773 cites W2005692768 @default.
- W4313894773 cites W2015555643 @default.
- W4313894773 cites W2027884537 @default.
- W4313894773 cites W2031110963 @default.
- W4313894773 cites W2039357091 @default.
- W4313894773 cites W2042655557 @default.
- W4313894773 cites W2049108945 @default.
- W4313894773 cites W2052843320 @default.
- W4313894773 cites W2053483807 @default.
- W4313894773 cites W2053909542 @default.
- W4313894773 cites W2059695645 @default.
- W4313894773 cites W2076624732 @default.
- W4313894773 cites W2082264875 @default.
- W4313894773 cites W2090452992 @default.
- W4313894773 cites W2090519212 @default.
- W4313894773 cites W2099748452 @default.
- W4313894773 cites W2101645005 @default.
- W4313894773 cites W2113427739 @default.
- W4313894773 cites W2124366846 @default.
- W4313894773 cites W2137587386 @default.
- W4313894773 cites W2147591077 @default.
- W4313894773 cites W2148787736 @default.
- W4313894773 cites W2163825333 @default.
- W4313894773 cites W2165035367 @default.
- W4313894773 cites W2188459427 @default.
- W4313894773 cites W2216791712 @default.
- W4313894773 cites W2418731479 @default.
- W4313894773 cites W2550652794 @default.
- W4313894773 cites W2869247200 @default.
- W4313894773 cites W2884987424 @default.
- W4313894773 cites W2890767151 @default.
- W4313894773 cites W2891999566 @default.
- W4313894773 cites W2907444491 @default.
- W4313894773 cites W2991510611 @default.
- W4313894773 cites W2996150678 @default.
- W4313894773 cites W3000396019 @default.
- W4313894773 cites W3006511740 @default.
- W4313894773 cites W3036804157 @default.
- W4313894773 cites W3042314115 @default.
- W4313894773 cites W3080673820 @default.
- W4313894773 cites W3085244668 @default.
- W4313894773 cites W3093643812 @default.
- W4313894773 cites W3124481512 @default.
- W4313894773 cites W3128515864 @default.
- W4313894773 cites W3133300142 @default.
- W4313894773 cites W4200072152 @default.
- W4313894773 cites W4211178015 @default.
- W4313894773 cites W4253534765 @default.
- W4313894773 doi "https://doi.org/10.3390/molecules28020606" @default.
- W4313894773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36677663" @default.
- W4313894773 hasPublicationYear "2023" @default.
- W4313894773 type Work @default.
- W4313894773 citedByCount "0" @default.
- W4313894773 crossrefType "journal-article" @default.
- W4313894773 hasAuthorship W4313894773A5000418548 @default.
- W4313894773 hasAuthorship W4313894773A5004095815 @default.
- W4313894773 hasAuthorship W4313894773A5024507727 @default.
- W4313894773 hasAuthorship W4313894773A5027982369 @default.
- W4313894773 hasAuthorship W4313894773A5032308726 @default.
- W4313894773 hasAuthorship W4313894773A5036415464 @default.
- W4313894773 hasAuthorship W4313894773A5040873811 @default.
- W4313894773 hasAuthorship W4313894773A5079143892 @default.
- W4313894773 hasAuthorship W4313894773A5080702907 @default.
- W4313894773 hasAuthorship W4313894773A5080946366 @default.
- W4313894773 hasAuthorship W4313894773A5085480749 @default.
- W4313894773 hasAuthorship W4313894773A5088778910 @default.
- W4313894773 hasBestOaLocation W43138947731 @default.
- W4313894773 hasConcept C2780670043 @default.
- W4313894773 hasConcept C2780917455 @default.
- W4313894773 hasConcept C556039675 @default.