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• W4313894958 abstract "Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women of reproductive age and features complex pathological symptoms and mechanisms. Existing medical treatments have, to some extent, alleviated the deterioration of PCOS. However, these strategies only temporarily control symptoms, with a few side effects and no preventive effect. Phytochemicals extracted from medicinal herbs and plants are vital for discovering novel drugs. In recent years, many kinds of research have proven that phytochemicals isolated from traditional Chinese medicine (TCM) and medicinal plants show significant potential in preventing, alleviating, and treating PCOS. Nevertheless, compared to the abundance of experimental literature and minimal specific-topic reviews related to PCOS, there is a lack of systematic reviews to summarize these advancements in this promising field. Under this background, we systematically document the progress of bioactive phytochemicals from TCM and medicinal plants in treating PCOS, including flavonoids, polyphenols, and alkaloids. According to the literature, these valuable phytochemicals demonstrated therapeutic effects on PCOS supported by in vivo and in vitro experiments, mainly depending on anti-inflammatory, antioxidation, improvement of hormone disorder and insulin resistance (IR), and alleviation of hyperinsulinemia. Based on the current progress, future research directions should emphasize 1) exploring bioactive phytochemicals that potentially mediate bone metabolism for the treatment of PCOS; 2) improving unsatisfactory bioavailability by using advanced drug delivery systems such as nanoparticles and antibody-conjugated drugs, as well as a chemical modification; 3) conducting in-depth research on the pathogenesis of PCOS to potentially impact the gut microbiota and its metabolites in the evolution of PCOS; 4) revealing the pharmacological effects of these bioactive phytochemicals on PCOS at the genetic level; and 5) exploring the hypothetical and unprecedented functions in regulating PCOS by serving as proteolysis-targeting chimeras and molecular glues compared with traditional small molecule drugs. In brief, this review aims to provide detailed mechanisms of these bioactive phytochemicals and hopefully practical and reliable insight into clinical applications concerning PCOS." @default.
• W4313894958 created "2023-01-10" @default.
• W4313894958 creator A5000970532 @default.
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• W4313894958 creator A5074782336 @default.
• W4313894958 date "2023-01-09" @default.
• W4313894958 modified "2023-10-05" @default.
• W4313894958 title "Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review" @default.
• W4313894958 cites W1577097214 @default.
• W4313894958 cites W1600579936 @default.
• W4313894958 cites W1833732902 @default.
• W4313894958 cites W1943352132 @default.
• W4313894958 cites W1967263394 @default.
• W4313894958 cites W1969137486 @default.
• W4313894958 cites W1978876989 @default.
• W4313894958 cites W1996079534 @default.
• W4313894958 cites W2004104620 @default.
• W4313894958 cites W2013220558 @default.
• W4313894958 cites W2017424172 @default.
• W4313894958 cites W2078399779 @default.
• W4313894958 cites W2093704782 @default.
• W4313894958 cites W2094124280 @default.
• W4313894958 cites W2095002885 @default.
• W4313894958 cites W2098825239 @default.
• W4313894958 cites W2099032911 @default.
• W4313894958 cites W2101304900 @default.
• W4313894958 cites W2108965120 @default.
• W4313894958 cites W2112553362 @default.
• W4313894958 cites W2133883611 @default.
• W4313894958 cites W2135136722 @default.
• W4313894958 cites W2149842750 @default.
• W4313894958 cites W2156639990 @default.
• W4313894958 cites W2166064965 @default.
• W4313894958 cites W2175568660 @default.
• W4313894958 cites W2176996276 @default.
• W4313894958 cites W2184254448 @default.
• W4313894958 cites W2275092747 @default.
• W4313894958 cites W2315308849 @default.
• W4313894958 cites W2343787569 @default.
• W4313894958 cites W2481420451 @default.
• W4313894958 cites W2503951330 @default.
• W4313894958 cites W2512316953 @default.
• W4313894958 cites W2520855313 @default.
• W4313894958 cites W2528009933 @default.
• W4313894958 cites W2532986090 @default.
• W4313894958 cites W2559715227 @default.
• W4313894958 cites W2559894203 @default.
• W4313894958 cites W2560430754 @default.
• W4313894958 cites W2582708849 @default.
• W4313894958 cites W2593220225 @default.
• W4313894958 cites W2601526802 @default.
• W4313894958 cites W2606086333 @default.
• W4313894958 cites W2615036945 @default.
• W4313894958 cites W2778921065 @default.
• W4313894958 cites W2780491695 @default.
• W4313894958 cites W2789602348 @default.
• W4313894958 cites W2790238124 @default.
• W4313894958 cites W2793887346 @default.
• W4313894958 cites W2797356095 @default.
• W4313894958 cites W2809459372 @default.
• W4313894958 cites W2811423579 @default.
• W4313894958 cites W2884536266 @default.
• W4313894958 cites W2885728935 @default.
• W4313894958 cites W2887267369 @default.
• W4313894958 cites W2890626455 @default.
• W4313894958 cites W2894528081 @default.
• W4313894958 cites W2894791893 @default.
• W4313894958 cites W2897496721 @default.
• W4313894958 cites W2897678356 @default.
• W4313894958 cites W2901786411 @default.
• W4313894958 cites W2909714309 @default.
• W4313894958 cites W2910511059 @default.
• W4313894958 cites W2910919923 @default.
• W4313894958 cites W2913006421 @default.
• W4313894958 cites W2914676097 @default.
• W4313894958 cites W2927405476 @default.
• W4313894958 cites W2938646408 @default.
• W4313894958 cites W2949336662 @default.
• W4313894958 cites W2954661505 @default.
• W4313894958 cites W2955294901 @default.
• W4313894958 cites W2962132860 @default.
• W4313894958 cites W2963061362 @default.
• W4313894958 cites W2963985015 @default.
• W4313894958 cites W2967458881 @default.
• W4313894958 cites W2971571305 @default.
• W4313894958 cites W2972100969 @default.
• W4313894958 cites W2972258394 @default.
• W4313894958 cites W2972582268 @default.
• W4313894958 cites W2980621889 @default.
• W4313894958 cites W2981592932 @default.
• W4313894958 cites W2982343068 @default.
• W4313894958 cites W2982554531 @default.

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