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- W4313895057 endingPage "382" @default.
- W4313895057 startingPage "382" @default.
- W4313895057 abstract "Ewing sarcoma is the second most common bone tumor in childhood and adolescence. Currently, first-line therapy includes multidrug chemotherapy with surgery and/or radiation. Although most patients initially respond to chemotherapy, recurrent tumors become treatment refractory. Pathologically, Ewing sarcoma consists of small round basophilic cells with prominent nuclei marked by expression of surface protein CD99. Genetically, Ewing sarcoma is driven by a fusion oncoprotein that results from one of a small number of chromosomal translocations composed of a FET gene and a gene encoding an ETS family transcription factor, with ~85% of tumors expressing the EWSR1::FLI1 fusion. EWSR1::FLI1 regulates transcription, splicing, genome instability and other cellular functions. Although a tumor-specific target, EWSR1::FLI1-targeted therapy has yet to be developed, largely due to insufficient understanding of EWSR1::FLI1 upstream and downstream signaling, and the challenges in targeting transcription factors with small molecules. In this review, we summarize the contemporary molecular understanding of Ewing sarcoma, and the post-transcriptional and post-translational regulatory mechanisms that control EWSR1::FLI1 function." @default.
- W4313895057 created "2023-01-10" @default.
- W4313895057 creator A5027549897 @default.
- W4313895057 creator A5041976491 @default.
- W4313895057 creator A5071663193 @default.
- W4313895057 date "2023-01-06" @default.
- W4313895057 modified "2023-10-16" @default.
- W4313895057 title "Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications" @default.
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