Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313897060> ?p ?o ?g. }
- W4313897060 endingPage "191" @default.
- W4313897060 startingPage "191" @default.
- W4313897060 abstract "Since late 2016, a yellow fever virus (YFV) variant carrying a set of nine amino acid variations has circulated in South America. Three of them were mapped on the methyltransferase (MTase) domain of viral NS5 protein. To assess whether these changes affected viral infectivity, we synthesized YFV carrying the MTase of circulating lineage as well as its isoform with the residues of the previous strains (NS5 K101R, NS5 V138I, and NS5 G173S). We observed a slight difference in viral growth properties and plaque phenotype between the two synthetic YFVs. However, the MTase polymorphisms associated with the Brazilian strain of YFV (2016–2019) confer more susceptibility to the IFN-I. In addition, in vitro MTase assay revealed that the interaction between the YFV MTase and the methyl donor molecule (SAM) is altered in the Brazilian MTase variant. Altogether, the results reported here describe that the MTase carrying the molecular signature of the Brazilian YFV circulating since 2016 might display a slight decrease in its catalytic activity but virtually no effect on viral fitness in the parameters comprised in this study. The most marked influence of these residues stands in the immune escape against the antiviral response mediated by IFN-I." @default.
- W4313897060 created "2023-01-10" @default.
- W4313897060 creator A5002795604 @default.
- W4313897060 creator A5030792536 @default.
- W4313897060 creator A5038446513 @default.
- W4313897060 creator A5039783946 @default.
- W4313897060 creator A5042192588 @default.
- W4313897060 creator A5048959338 @default.
- W4313897060 creator A5068775377 @default.
- W4313897060 creator A5079344923 @default.
- W4313897060 date "2023-01-10" @default.
- W4313897060 modified "2023-09-30" @default.
- W4313897060 title "Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host’s Immune Evasion Mediated by Type I Interferon" @default.
- W4313897060 cites W1600954550 @default.
- W4313897060 cites W1602620419 @default.
- W4313897060 cites W1607931568 @default.
- W4313897060 cites W1639795491 @default.
- W4313897060 cites W1781506009 @default.
- W4313897060 cites W1972565935 @default.
- W4313897060 cites W1976222107 @default.
- W4313897060 cites W1982094437 @default.
- W4313897060 cites W1982898421 @default.
- W4313897060 cites W1983396822 @default.
- W4313897060 cites W1985008932 @default.
- W4313897060 cites W1986435822 @default.
- W4313897060 cites W1992192767 @default.
- W4313897060 cites W2021928505 @default.
- W4313897060 cites W2023858529 @default.
- W4313897060 cites W2027598863 @default.
- W4313897060 cites W2027897465 @default.
- W4313897060 cites W2050843600 @default.
- W4313897060 cites W2053012994 @default.
- W4313897060 cites W2058492139 @default.
- W4313897060 cites W2074763090 @default.
- W4313897060 cites W2099611900 @default.
- W4313897060 cites W2106154817 @default.
- W4313897060 cites W2107132989 @default.
- W4313897060 cites W2113418045 @default.
- W4313897060 cites W2124008723 @default.
- W4313897060 cites W2125092517 @default.
- W4313897060 cites W2141066880 @default.
- W4313897060 cites W2152181056 @default.
- W4313897060 cites W2154480405 @default.
- W4313897060 cites W2157843878 @default.
- W4313897060 cites W2158025472 @default.
- W4313897060 cites W2228117528 @default.
- W4313897060 cites W2343614482 @default.
- W4313897060 cites W2529745498 @default.
- W4313897060 cites W2565960883 @default.
- W4313897060 cites W2603874280 @default.
- W4313897060 cites W2607492224 @default.
- W4313897060 cites W2611763920 @default.
- W4313897060 cites W2741822339 @default.
- W4313897060 cites W2804822363 @default.
- W4313897060 cites W2883450420 @default.
- W4313897060 cites W2888118719 @default.
- W4313897060 cites W2915031928 @default.
- W4313897060 cites W2943702971 @default.
- W4313897060 cites W2952888071 @default.
- W4313897060 cites W3005839922 @default.
- W4313897060 cites W3047642829 @default.
- W4313897060 cites W3129197659 @default.
- W4313897060 cites W4211156111 @default.
- W4313897060 cites W4212919720 @default.
- W4313897060 doi "https://doi.org/10.3390/v15010191" @default.
- W4313897060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36680231" @default.
- W4313897060 hasPublicationYear "2023" @default.
- W4313897060 type Work @default.
- W4313897060 citedByCount "1" @default.
- W4313897060 countsByYear W43138970602023 @default.
- W4313897060 crossrefType "journal-article" @default.
- W4313897060 hasAuthorship W4313897060A5002795604 @default.
- W4313897060 hasAuthorship W4313897060A5030792536 @default.
- W4313897060 hasAuthorship W4313897060A5038446513 @default.
- W4313897060 hasAuthorship W4313897060A5039783946 @default.
- W4313897060 hasAuthorship W4313897060A5042192588 @default.
- W4313897060 hasAuthorship W4313897060A5048959338 @default.
- W4313897060 hasAuthorship W4313897060A5068775377 @default.
- W4313897060 hasAuthorship W4313897060A5079344923 @default.
- W4313897060 hasBestOaLocation W43138970601 @default.
- W4313897060 hasConcept C104317684 @default.
- W4313897060 hasConcept C106358424 @default.
- W4313897060 hasConcept C159047783 @default.
- W4313897060 hasConcept C2522874641 @default.
- W4313897060 hasConcept C2776178377 @default.
- W4313897060 hasConcept C33288867 @default.
- W4313897060 hasConcept C515207424 @default.
- W4313897060 hasConcept C54355233 @default.
- W4313897060 hasConcept C86803240 @default.
- W4313897060 hasConcept C8891405 @default.
- W4313897060 hasConcept C91965660 @default.
- W4313897060 hasConceptScore W4313897060C104317684 @default.
- W4313897060 hasConceptScore W4313897060C106358424 @default.
- W4313897060 hasConceptScore W4313897060C159047783 @default.
- W4313897060 hasConceptScore W4313897060C2522874641 @default.
- W4313897060 hasConceptScore W4313897060C2776178377 @default.
- W4313897060 hasConceptScore W4313897060C33288867 @default.
- W4313897060 hasConceptScore W4313897060C515207424 @default.