FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313897263> ?p ?o ?g. }

• W4313897263 endingPage "100012" @default.
• W4313897263 startingPage "100012" @default.
• W4313897263 abstract "Mismatch repair (MMR) protein expression in colorectal cancer (CRC) cells is usually homogeneously retained or lost. Rare lesions may show a heterogeneous pattern of MMR protein expression. We evaluated MMR protein expression (MLH1, MSH2, MSH6, and PMS2) in 200 CRCs, identifying 3 groups with proficient MMR protein expression (MMRp), deficient MMR protein expression (MMRd), and heterogeneous MMR protein expression (MMRh). MMRh tumors were microdissected on the basis of the expression of the heterogeneous marker. DNA was extracted and subjected to targeted sequencing. RNA was purified from bulk tumors of all MMRh cases and in a control series of 15 MMRp and 10 MMRd CRCs and analyzed using the PanCancer IO 360 Panel (NanoString Technologies). Twenty-nine of the 200 cases (14.5%) were MMRd. Nine cases (4.5%) showed a heterogeneous pattern of MMR expression, with 6 tumors harboring concomitant loss of one of the other MMR proteins, thus featuring areas with double loss at immunohistochemistry (IHC) testing (MMRh double-loss cases). Four of the 6 MMRh double-loss cases were suitable for a separate sequence variant analysis of IHC double-negative and IHC single-negative components of the tumor. In all lesions, both components exhibited a high tumor mutation burden (TMB). Nevertheless, a significant increase in TMB in the double-negative components was observed (mean TMB: negative, 70 mut/Mb vs positive, 59 mut/Mb) because of a higher number of subclonal variants compared with the other component. Comparative gene expression analyses among MMRd, MMRp, and MMRh CRCs highlighted differential gene expression patterns and an increased number of tumor-infiltrating lymphocytes in MMRh lesions, which is also characterized by a substantial population of exhausted CD8+ lymphocytes. We describe a unique subgroup of CRCs showing heterogeneous expression of MMR proteins in a background of concomitant loss of one of the other markers." @default.
• W4313897263 created "2023-01-10" @default.
• W4313897263 creator A5006266882 @default.
• W4313897263 creator A5015304250 @default.
• W4313897263 creator A5021452701 @default.
• W4313897263 creator A5024586369 @default.
• W4313897263 creator A5029932861 @default.
• W4313897263 creator A5048730950 @default.
• W4313897263 creator A5061063857 @default.
• W4313897263 creator A5062573518 @default.
• W4313897263 creator A5064011158 @default.
• W4313897263 creator A5065261887 @default.
• W4313897263 creator A5072215630 @default.
• W4313897263 creator A5080135856 @default.
• W4313897263 creator A5080269874 @default.
• W4313897263 creator A5084972491 @default.
• W4313897263 creator A5089164502 @default.
• W4313897263 date "2023-02-01" @default.
• W4313897263 modified "2023-10-17" @default.
• W4313897263 title "Unique Patterns of Heterogeneous Mismatch Repair Protein Expression in Colorectal Cancer Unveil Different Degrees of Tumor Mutational Burden and Distinct Tumor Microenvironment Features" @default.
• W4313897263 cites W1500207531 @default.
• W4313897263 cites W1940241680 @default.
• W4313897263 cites W1993928295 @default.
• W4313897263 cites W2003056152 @default.
• W4313897263 cites W2037898576 @default.
• W4313897263 cites W2047524584 @default.
• W4313897263 cites W2096731080 @default.
• W4313897263 cites W2110576461 @default.
• W4313897263 cites W2123016804 @default.
• W4313897263 cites W2123636561 @default.
• W4313897263 cites W2147698761 @default.
• W4313897263 cites W2319768699 @default.
• W4313897263 cites W2529308344 @default.
• W4313897263 cites W2587610309 @default.
• W4313897263 cites W2622499649 @default.
• W4313897263 cites W2725858612 @default.
• W4313897263 cites W2739132742 @default.
• W4313897263 cites W2767034994 @default.
• W4313897263 cites W2899144445 @default.
• W4313897263 cites W2901973709 @default.
• W4313897263 cites W2913771208 @default.
• W4313897263 cites W2914110277 @default.
• W4313897263 cites W2987320134 @default.
• W4313897263 cites W3005406258 @default.
• W4313897263 cites W3087683890 @default.
• W4313897263 cites W3135115294 @default.
• W4313897263 cites W3165700588 @default.
• W4313897263 cites W3200790344 @default.
• W4313897263 cites W3201192244 @default.
• W4313897263 cites W3201228616 @default.
• W4313897263 cites W4200558611 @default.
• W4313897263 cites W4220895263 @default.
• W4313897263 cites W4293475317 @default.
• W4313897263 doi "https://doi.org/10.1016/j.modpat.2022.100012" @default.
• W4313897263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36853785" @default.
• W4313897263 hasPublicationYear "2023" @default.
• W4313897263 type Work @default.
• W4313897263 citedByCount "4" @default.
• W4313897263 countsByYear W43138972632023 @default.
• W4313897263 crossrefType "journal-article" @default.
• W4313897263 hasAuthorship W4313897263A5006266882 @default.
• W4313897263 hasAuthorship W4313897263A5015304250 @default.
• W4313897263 hasAuthorship W4313897263A5021452701 @default.
• W4313897263 hasAuthorship W4313897263A5024586369 @default.
• W4313897263 hasAuthorship W4313897263A5029932861 @default.
• W4313897263 hasAuthorship W4313897263A5048730950 @default.
• W4313897263 hasAuthorship W4313897263A5061063857 @default.
• W4313897263 hasAuthorship W4313897263A5062573518 @default.
• W4313897263 hasAuthorship W4313897263A5064011158 @default.
• W4313897263 hasAuthorship W4313897263A5065261887 @default.
• W4313897263 hasAuthorship W4313897263A5072215630 @default.
• W4313897263 hasAuthorship W4313897263A5080135856 @default.
• W4313897263 hasAuthorship W4313897263A5080269874 @default.
• W4313897263 hasAuthorship W4313897263A5084972491 @default.
• W4313897263 hasAuthorship W4313897263A5089164502 @default.
• W4313897263 hasBestOaLocation W43138972631 @default.
• W4313897263 hasConcept C104317684 @default.
• W4313897263 hasConcept C111425858 @default.
• W4313897263 hasConcept C121608353 @default.
• W4313897263 hasConcept C142724271 @default.
• W4313897263 hasConcept C150194340 @default.
• W4313897263 hasConcept C204232928 @default.
• W4313897263 hasConcept C2776559941 @default.
• W4313897263 hasConcept C2776674815 @default.
• W4313897263 hasConcept C2778677574 @default.
• W4313897263 hasConcept C2779115348 @default.
• W4313897263 hasConcept C501734568 @default.
• W4313897263 hasConcept C502942594 @default.
• W4313897263 hasConcept C526805850 @default.
• W4313897263 hasConcept C54355233 @default.
• W4313897263 hasConcept C60748783 @default.
• W4313897263 hasConcept C71924100 @default.
• W4313897263 hasConcept C86803240 @default.
• W4313897263 hasConceptScore W4313897263C104317684 @default.
• W4313897263 hasConceptScore W4313897263C111425858 @default.
• W4313897263 hasConceptScore W4313897263C121608353 @default.
• W4313897263 hasConceptScore W4313897263C142724271 @default.
• W4313897263 hasConceptScore W4313897263C150194340 @default.

• next