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- W4313897521 abstract "Aging is the predominant risk factor for atherosclerosis—the leading cause of death. Rare smooth muscle cell (SMC) progenitors clonally expand, giving rise to up to ~70% of atherosclerotic plaque cells; however, the effect of age on SMC clonality is not known. Our results indicate that aged bone marrow (BM)-derived cells noncell autonomously induce SMC polyclonality and worsen atherosclerosis. Indeed, in myeloid cells from aged mice and humans, TET2 levels are decreased, which epigenetically silences integrin β3, resulting in increased tumor necrosis factor-α (TNFα) signaling. TNFα signals through TNF receptor 1 on SMCs to promote proliferation, and induces the recruitment and expansion of multiple SMC progenitors into the atherosclerotic plaque. Notably, integrin β3 overexpression in aged BM preserves the dominance of the lineage of a single SMC progenitor and attenuates the plaque burden. Our results demonstrate a molecular mechanism of aged macrophage-induced SMC polyclonality and atherogenesis and suggest novel therapeutic strategies. Kabir et al. show that aged bone marrow induces smooth muscle cell (SMC) polyclonality in atherosclerosis. Decreased TET2 levels in aged myeloid cells lead to silenced integrin β3, resulting in increased TNFα signaling and the expansion of multiple SMC progenitors." @default.
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- W4313897521 date "2023-01-09" @default.
- W4313897521 modified "2023-10-14" @default.
- W4313897521 title "The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques" @default.
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- W4313897521 cites W1996612611 @default.
- W4313897521 cites W1997443963 @default.
- W4313897521 cites W1997998180 @default.
- W4313897521 cites W2007154529 @default.
- W4313897521 cites W2019832656 @default.
- W4313897521 cites W2028890259 @default.
- W4313897521 cites W2031047943 @default.
- W4313897521 cites W2033002831 @default.
- W4313897521 cites W2036505292 @default.
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- W4313897521 cites W2171239535 @default.
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- W4313897521 cites W2606527202 @default.
- W4313897521 cites W2628145035 @default.
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- W4313897521 cites W2898549090 @default.
- W4313897521 cites W2955108563 @default.
- W4313897521 cites W2966605790 @default.
- W4313897521 cites W2967463001 @default.
- W4313897521 cites W2981329637 @default.
- W4313897521 cites W3003949123 @default.
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- W4313897521 cites W3133289732 @default.
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- W4313897521 doi "https://doi.org/10.1038/s43587-022-00342-5" @default.
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