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• W4313897926 endingPage "107722" @default.
• W4313897926 startingPage "107722" @default.
• W4313897926 abstract "Drug use during adolescence results in a life-long risk to develop substance-use disorders. Adolescent rats are sensitive to different drug-associated cues, compared to adults; however, the contribution of adolescent-formed context-drug-associations to elicit relapse-like behavior is underexplored.The present study compared the effect of adolescent vs adult-formed context-drug associations to elicit time-dependent increases in cocaine-seeking behavior. This objective was accomplished using an abbreviated (ABRV) operant cocaine self-administration (Coc-SA), Extinction (EXT) paradigm, with cocaine-seeking tests occurring 1 day after training (T1, early relapse) or following 15 days of abstinence (T15, late relapse).Adolescent and adult rats received ABRV Coc-SA in a distinct context (2 hr, 2x/day over 5 days) then EXT in a second context (2 hr, 2x/day over 4 days). Adolescent or adult cocaine-exposed rats were then tested (2 hr, non-rewarded) in either the previous EXT or Coc-paired contexts during early or late relapse.As previously reported, both adolescent and adult cocaine-exposed rats displayed similar magnitudes of cocaine intake and lever presses during Coc-SA, EXT, and early relapse. Independent analysis of adolescent and adult groups revealed differences in lever responding, specifically rats with cocaine exposure during adolescence showed time-dependent increases in lever responding during late relapse. These data suggest that cocaine-context associations formed during adolescence can elicit craving during adulthood and that these age-specific differences in contextual sensitivity may not be immediately observed at early relapse periods." @default.
• W4313897926 created "2023-01-10" @default.
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• W4313897926 date "2023-03-01" @default.
• W4313897926 modified "2023-10-15" @default.
• W4313897926 title "Context-drug-associations and reinstatement of drug-seeking behavior in male rats: Adolescent and adult time-dependent effects" @default.
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• W4313897926 doi "https://doi.org/10.1016/j.nlm.2023.107722" @default.
• W4313897926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36639018" @default.
• W4313897926 hasPublicationYear "2023" @default.
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