Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313897948> ?p ?o ?g. }
- W4313897948 endingPage "429" @default.
- W4313897948 startingPage "429" @default.
- W4313897948 abstract "Mutations in the tumor suppressor p53 (p53) promote cancer progression. This is mainly due to loss of function (LOS) as a tumor suppressor, dominant-negative (DN) activities of missense mutant p53 (mutp53) over wild-type p53 (wtp53), and wtp53-independent oncogenic activities of missense mutp53 by interacting with other tumor suppressors or oncogenes (gain of function: GOF). Since p53 mutations occur in ~50% of human cancers and rarely occur in normal tissues, p53 mutations are cancer-specific and ideal therapeutic targets. Approaches to target p53 mutations include (1) restoration or stabilization of wtp53 conformation from missense mutp53, (2) rescue of p53 nonsense mutations, (3) depletion or degradation of mutp53 proteins, and (4) induction of p53 synthetic lethality or targeting of vulnerabilities imposed by p53 mutations (enhanced YAP/TAZ activities) or deletions (hyperactivated retrotransposons). This review article focuses on clinically available FDA-approved drugs and drugs in clinical trials that target p53 mutations and summarizes their mechanisms of action and activities to suppress cancer progression." @default.
- W4313897948 created "2023-01-10" @default.
- W4313897948 creator A5018838856 @default.
- W4313897948 creator A5043198099 @default.
- W4313897948 date "2023-01-09" @default.
- W4313897948 modified "2023-10-03" @default.
- W4313897948 title "Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials" @default.
- W4313897948 cites W1510669790 @default.
- W4313897948 cites W1580430519 @default.
- W4313897948 cites W1591934633 @default.
- W4313897948 cites W1657803481 @default.
- W4313897948 cites W1674633125 @default.
- W4313897948 cites W1893278446 @default.
- W4313897948 cites W1964355198 @default.
- W4313897948 cites W1965374233 @default.
- W4313897948 cites W1975472455 @default.
- W4313897948 cites W1982890673 @default.
- W4313897948 cites W1984461083 @default.
- W4313897948 cites W1991660464 @default.
- W4313897948 cites W1994637376 @default.
- W4313897948 cites W1997659862 @default.
- W4313897948 cites W1997730815 @default.
- W4313897948 cites W1999122619 @default.
- W4313897948 cites W1999358741 @default.
- W4313897948 cites W2000302853 @default.
- W4313897948 cites W2001313658 @default.
- W4313897948 cites W2004480757 @default.
- W4313897948 cites W2011452661 @default.
- W4313897948 cites W2014097228 @default.
- W4313897948 cites W2022529631 @default.
- W4313897948 cites W2023473560 @default.
- W4313897948 cites W2023886879 @default.
- W4313897948 cites W2026761771 @default.
- W4313897948 cites W2028495676 @default.
- W4313897948 cites W2030217455 @default.
- W4313897948 cites W2034227568 @default.
- W4313897948 cites W2034330475 @default.
- W4313897948 cites W2035263093 @default.
- W4313897948 cites W2035458878 @default.
- W4313897948 cites W2035641566 @default.
- W4313897948 cites W2036358056 @default.
- W4313897948 cites W2041045680 @default.
- W4313897948 cites W2051535801 @default.
- W4313897948 cites W2052287702 @default.
- W4313897948 cites W2052297334 @default.
- W4313897948 cites W2058769115 @default.
- W4313897948 cites W2074477570 @default.
- W4313897948 cites W2075676198 @default.
- W4313897948 cites W2087666423 @default.
- W4313897948 cites W2090231065 @default.
- W4313897948 cites W2092902276 @default.
- W4313897948 cites W2094595413 @default.
- W4313897948 cites W2094957670 @default.
- W4313897948 cites W2096293110 @default.
- W4313897948 cites W2097803438 @default.
- W4313897948 cites W2098098349 @default.
- W4313897948 cites W2099031921 @default.
- W4313897948 cites W2101292261 @default.
- W4313897948 cites W2101379344 @default.
- W4313897948 cites W2102368462 @default.
- W4313897948 cites W2108761265 @default.
- W4313897948 cites W2113523455 @default.
- W4313897948 cites W2116393881 @default.
- W4313897948 cites W2116396683 @default.
- W4313897948 cites W2117430947 @default.
- W4313897948 cites W2117854357 @default.
- W4313897948 cites W2119506861 @default.
- W4313897948 cites W2125568481 @default.
- W4313897948 cites W2130164812 @default.
- W4313897948 cites W2131822545 @default.
- W4313897948 cites W2137132470 @default.
- W4313897948 cites W2142180745 @default.
- W4313897948 cites W2146146418 @default.
- W4313897948 cites W2146642286 @default.
- W4313897948 cites W2148056172 @default.
- W4313897948 cites W2148303621 @default.
- W4313897948 cites W2149133771 @default.
- W4313897948 cites W2150144117 @default.
- W4313897948 cites W2153635460 @default.
- W4313897948 cites W2157861211 @default.
- W4313897948 cites W2158402891 @default.
- W4313897948 cites W2158958901 @default.
- W4313897948 cites W2159038842 @default.
- W4313897948 cites W2160854466 @default.
- W4313897948 cites W2161892620 @default.
- W4313897948 cites W2165582413 @default.
- W4313897948 cites W2170325085 @default.
- W4313897948 cites W2200414333 @default.
- W4313897948 cites W2210624024 @default.
- W4313897948 cites W2213777869 @default.
- W4313897948 cites W2260679659 @default.
- W4313897948 cites W2265116878 @default.
- W4313897948 cites W226969713 @default.
- W4313897948 cites W2276371085 @default.
- W4313897948 cites W2283490826 @default.
- W4313897948 cites W2289144550 @default.
- W4313897948 cites W2295041004 @default.
- W4313897948 cites W2308583034 @default.