Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313898489> ?p ?o ?g. }
- W4313898489 endingPage "123214" @default.
- W4313898489 startingPage "123214" @default.
- W4313898489 abstract "It remains uncertain how brain glycosaminoglycans (GAGs) contribute to the progression of inflammatory disorders like multiple sclerosis (MS). We investigated here neuroinflammation-mediated changes in GAG composition and metabolism using the mouse model of experimental autoimmune encephalomyelitis (EAE) and sham-immunized mice as controls. Cerebellum, mid- and forebrain at different EAE phases were investigated using gene expression analysis (microarray and RT-qPCR) as well as HPLC quantification of CS and hyaluronic acid (HA). The cerebellum was the most affected brain region showing a downregulation of Bcan, Cspg5, and an upregulation of Dse, Gusb, Hexb, Dcn and Has2 at peak EAE. Upregulation of genes involved in GAG degradation as well as synthesis of HA and decorin persisted from onset to peak, and diminished at remission, suggesting a severity-related decrease in CS and increments in HA. Relative disaccharide quantification confirmed a 3.6 % reduction of CS-4S at peak and a normalization during remission, while HA increased in both phases by 26.1 % and 17.6 %, respectively. Early inflammatory processes led to altered GAG metabolism in early EAE stages and subsequent partially reversible changes in CS-4S and in HA. Targeting early modifications in CS could potentially mitigate progression of EAE/MS." @default.
- W4313898489 created "2023-01-10" @default.
- W4313898489 creator A5000754720 @default.
- W4313898489 creator A5008677196 @default.
- W4313898489 creator A5021719362 @default.
- W4313898489 creator A5033562949 @default.
- W4313898489 creator A5042996842 @default.
- W4313898489 creator A5046262772 @default.
- W4313898489 creator A5049288849 @default.
- W4313898489 creator A5049736067 @default.
- W4313898489 creator A5066508060 @default.
- W4313898489 creator A5070428405 @default.
- W4313898489 date "2023-03-01" @default.
- W4313898489 modified "2023-10-09" @default.
- W4313898489 title "Brain inflammation induces alterations in glycosaminoglycan metabolism and subsequent changes in CS-4S and hyaluronic acid" @default.
- W4313898489 cites W1165970735 @default.
- W4313898489 cites W1913314522 @default.
- W4313898489 cites W1918018801 @default.
- W4313898489 cites W1925030390 @default.
- W4313898489 cites W1975219368 @default.
- W4313898489 cites W1980361506 @default.
- W4313898489 cites W1981131286 @default.
- W4313898489 cites W1993314807 @default.
- W4313898489 cites W1997632919 @default.
- W4313898489 cites W1998134697 @default.
- W4313898489 cites W2003726233 @default.
- W4313898489 cites W2004785268 @default.
- W4313898489 cites W2015046595 @default.
- W4313898489 cites W2015167429 @default.
- W4313898489 cites W2018504402 @default.
- W4313898489 cites W2037725018 @default.
- W4313898489 cites W2049493406 @default.
- W4313898489 cites W2050333516 @default.
- W4313898489 cites W2057181320 @default.
- W4313898489 cites W2057694188 @default.
- W4313898489 cites W2080059726 @default.
- W4313898489 cites W2108005154 @default.
- W4313898489 cites W2114570899 @default.
- W4313898489 cites W2117377859 @default.
- W4313898489 cites W2120865735 @default.
- W4313898489 cites W2166746630 @default.
- W4313898489 cites W2167750482 @default.
- W4313898489 cites W2216381261 @default.
- W4313898489 cites W2263928400 @default.
- W4313898489 cites W2340761255 @default.
- W4313898489 cites W2344942352 @default.
- W4313898489 cites W2782260459 @default.
- W4313898489 cites W2794299761 @default.
- W4313898489 cites W2904871119 @default.
- W4313898489 cites W2977439948 @default.
- W4313898489 cites W2999414303 @default.
- W4313898489 cites W3155477883 @default.
- W4313898489 cites W3195895542 @default.
- W4313898489 cites W4211090999 @default.
- W4313898489 cites W4221042061 @default.
- W4313898489 cites W4285089945 @default.
- W4313898489 cites W61719800 @default.
- W4313898489 doi "https://doi.org/10.1016/j.ijbiomac.2023.123214" @default.
- W4313898489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634800" @default.
- W4313898489 hasPublicationYear "2023" @default.
- W4313898489 type Work @default.
- W4313898489 citedByCount "1" @default.
- W4313898489 countsByYear W43138984892023 @default.
- W4313898489 crossrefType "journal-article" @default.
- W4313898489 hasAuthorship W4313898489A5000754720 @default.
- W4313898489 hasAuthorship W4313898489A5008677196 @default.
- W4313898489 hasAuthorship W4313898489A5021719362 @default.
- W4313898489 hasAuthorship W4313898489A5033562949 @default.
- W4313898489 hasAuthorship W4313898489A5042996842 @default.
- W4313898489 hasAuthorship W4313898489A5046262772 @default.
- W4313898489 hasAuthorship W4313898489A5049288849 @default.
- W4313898489 hasAuthorship W4313898489A5049736067 @default.
- W4313898489 hasAuthorship W4313898489A5066508060 @default.
- W4313898489 hasAuthorship W4313898489A5070428405 @default.
- W4313898489 hasConcept C104317684 @default.
- W4313898489 hasConcept C127561419 @default.
- W4313898489 hasConcept C134018914 @default.
- W4313898489 hasConcept C153074725 @default.
- W4313898489 hasConcept C185592680 @default.
- W4313898489 hasConcept C203014093 @default.
- W4313898489 hasConcept C2776914184 @default.
- W4313898489 hasConcept C2777529286 @default.
- W4313898489 hasConcept C2777899865 @default.
- W4313898489 hasConcept C2778486448 @default.
- W4313898489 hasConcept C2779652256 @default.
- W4313898489 hasConcept C2779830541 @default.
- W4313898489 hasConcept C2780640218 @default.
- W4313898489 hasConcept C54355233 @default.
- W4313898489 hasConcept C55493867 @default.
- W4313898489 hasConcept C86803240 @default.
- W4313898489 hasConcept C87753298 @default.
- W4313898489 hasConceptScore W4313898489C104317684 @default.
- W4313898489 hasConceptScore W4313898489C127561419 @default.
- W4313898489 hasConceptScore W4313898489C134018914 @default.
- W4313898489 hasConceptScore W4313898489C153074725 @default.
- W4313898489 hasConceptScore W4313898489C185592680 @default.
- W4313898489 hasConceptScore W4313898489C203014093 @default.
- W4313898489 hasConceptScore W4313898489C2776914184 @default.