Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313909239> ?p ?o ?g. }
- W4313909239 abstract "Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging characteristics of human absence seizures. Neuronally, seizures feature overall decreased but rhythmic firing of neurons in cortex and thalamus. Individual cortical and thalamic neurons express one of four distinct patterns of seizure-associated activity, one of which causes a transient initial peak in overall firing at seizure onset, and another which drives sustained decreases in overall firing. 40-60 s before seizure onset there begins a decline in low frequency electroencephalographic activity, neuronal firing, and behavior, but an increase in higher frequency electroencephalography and rhythmicity of neuronal firing. Our findings demonstrate that prolonged brain state changes precede consciousness-impairing seizures, and that during seizures distinct functional groups of cortical and thalamic neurons produce an overall transient firing increase followed by a sustained firing decrease, and increased rhythmicity." @default.
- W4313909239 created "2023-01-10" @default.
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- W4313909239 date "2023-01-10" @default.
- W4313909239 modified "2023-10-07" @default.
- W4313909239 title "Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures" @default.
- W4313909239 cites W132665086 @default.
- W4313909239 cites W1519118876 @default.
- W4313909239 cites W1519673444 @default.
- W4313909239 cites W1583209675 @default.
- W4313909239 cites W1713903328 @default.
- W4313909239 cites W1840565448 @default.
- W4313909239 cites W1886118302 @default.
- W4313909239 cites W1904639934 @default.
- W4313909239 cites W1964824984 @default.
- W4313909239 cites W1965103354 @default.
- W4313909239 cites W1966159115 @default.
- W4313909239 cites W1968545277 @default.
- W4313909239 cites W1969635562 @default.
- W4313909239 cites W1972996312 @default.
- W4313909239 cites W1979138336 @default.
- W4313909239 cites W1980276616 @default.
- W4313909239 cites W1985014120 @default.
- W4313909239 cites W1991560147 @default.
- W4313909239 cites W2003251132 @default.
- W4313909239 cites W2012777073 @default.
- W4313909239 cites W2014460514 @default.
- W4313909239 cites W2014721375 @default.
- W4313909239 cites W2019747077 @default.
- W4313909239 cites W2021281924 @default.
- W4313909239 cites W2033349308 @default.
- W4313909239 cites W2038302980 @default.
- W4313909239 cites W2038810510 @default.
- W4313909239 cites W2039341631 @default.
- W4313909239 cites W2044777670 @default.
- W4313909239 cites W2047892262 @default.
- W4313909239 cites W2048308976 @default.
- W4313909239 cites W2050812535 @default.
- W4313909239 cites W2052212681 @default.
- W4313909239 cites W2053214309 @default.
- W4313909239 cites W2056575661 @default.
- W4313909239 cites W2058669942 @default.
- W4313909239 cites W2064113649 @default.
- W4313909239 cites W2070361344 @default.
- W4313909239 cites W2075712743 @default.
- W4313909239 cites W2089513832 @default.
- W4313909239 cites W2098303658 @default.
- W4313909239 cites W2106193847 @default.
- W4313909239 cites W2109108729 @default.
- W4313909239 cites W2111479173 @default.
- W4313909239 cites W2111998656 @default.
- W4313909239 cites W2114104729 @default.
- W4313909239 cites W2121584771 @default.
- W4313909239 cites W2124631936 @default.
- W4313909239 cites W2132295790 @default.
- W4313909239 cites W2142628980 @default.
- W4313909239 cites W2143149526 @default.
- W4313909239 cites W2143534230 @default.
- W4313909239 cites W2150497419 @default.
- W4313909239 cites W2152230432 @default.
- W4313909239 cites W2167518632 @default.
- W4313909239 cites W2167981126 @default.
- W4313909239 cites W2331117864 @default.
- W4313909239 cites W2509831721 @default.
- W4313909239 cites W2511065090 @default.
- W4313909239 cites W2549946685 @default.
- W4313909239 cites W2588392021 @default.
- W4313909239 cites W2616863796 @default.
- W4313909239 cites W2624100641 @default.
- W4313909239 cites W2713069409 @default.
- W4313909239 cites W2734436227 @default.
- W4313909239 cites W2755671230 @default.
- W4313909239 cites W2765627740 @default.
- W4313909239 cites W2797102036 @default.
- W4313909239 cites W2804367002 @default.