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- W4315433180 abstract "Chronic non-healing wounds have posed a severe threat to patients mentally and physically. Behavior dysregulation of remaining cells at wound sites is recognized as the chief culprit to destroy healing process and hinders wound healing. Therefore, regulating and restoring normal cellular behavior is the core of chronic non-healing wound treatment. In recent years, the therapy with mesenchymal stem cells (MSCs) has become a promising option for chronic wound healing and the efficacy has increasingly been attributed to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) are reported to benefit almost all stages of wound healing by regulating the cellular behavior to participate in the process of inflammatory response, angiogenesis, re-epithelization, and scarless healing. Here, we describe the characteristics of MSC-sEVs and discuss their therapeutic potential in chronic wound treatment. Additionally, we also provide an overview of the application avenues of MSC-sEVs in wound treatment. Finally, we summarize strategies for large-scale production and engineering of MSC-sEVs. This review may possibly provide meaningful guidance for chronic wound treatment with MSC-sEVs." @default.
- W4315433180 created "2023-01-11" @default.
- W4315433180 creator A5001764975 @default.
- W4315433180 creator A5003250266 @default.
- W4315433180 creator A5012955908 @default.
- W4315433180 creator A5014902558 @default.
- W4315433180 creator A5041123457 @default.
- W4315433180 creator A5041951758 @default.
- W4315433180 creator A5064165881 @default.
- W4315433180 creator A5069896801 @default.
- W4315433180 creator A5083247969 @default.
- W4315433180 creator A5089030416 @default.
- W4315433180 date "2023-01-10" @default.
- W4315433180 modified "2023-10-01" @default.
- W4315433180 title "Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment" @default.
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