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• W4315433392 abstract "Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) constitutes a heterogeneous subset of ALL with a uniformly unfavorable prognosis. The identification of mutations amenable to treatment with tyrosine kinase-inhibitors (TKIs) represents a promising field of investigation. We report the case of a young patient affected by relapsed/refractory Ph-like ALL treated with chimeric antigen receptor T (CAR-T) cells after successful bridging with compassionate-use ponatinib and low-dose prednisone. We restarted low-dose ponatinib maintenance three months later. Twenty months later, measurable residual disease negativity and B-cell aplasia persist. To the best of our knowledge, this is the first case reporting the use of ponatinib in Ph-like ALL as a bridge to and maintenance after CAR-T cell therapy." @default.
• W4315433392 created "2023-01-11" @default.
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• W4315433392 date "2023-01-10" @default.
• W4315433392 modified "2023-10-14" @default.
• W4315433392 title "Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia" @default.
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• W4315433392 doi "https://doi.org/10.3389/fonc.2022.1100105" @default.
• W4315433392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36733349" @default.
• W4315433392 hasPublicationYear "2023" @default.
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