Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315433997> ?p ?o ?g. }
- W4315433997 abstract "Parkinson's disease (PD) is a chronic neurodegenerative disease that is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain (SNpc). Extensive studies into genetic and cellular models of PD implicate protein trafficking as a prominent contributor to the death of these dopaminergic neurons. Considerable evidence also suggests the involvement of α-synuclein as a central component of the characteristic cell death in PD and it is a major structural constituent of proteinaceous inclusion bodies (Lewy bodies; LB). α-synuclein research has been a vital part of PD research in recent years, with newly discovered evidence suggesting that α-synuclein can propagate through the brain via prion-like mechanisms. Healthy cells can internalize toxic α-synuclein species and seed endogenous α-synuclein to form large, pathogenic aggregates and form LBs. A better understanding of how α-synuclein can propagate, enter and be cleared from the cell is vital for therapeutic strategies." @default.
- W4315433997 created "2023-01-11" @default.
- W4315433997 creator A5016751691 @default.
- W4315433997 creator A5057332536 @default.
- W4315433997 creator A5062130744 @default.
- W4315433997 date "2023-01-10" @default.
- W4315433997 modified "2023-09-23" @default.
- W4315433997 title "The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease" @default.
- W4315433997 cites W1048390352 @default.
- W4315433997 cites W1484618835 @default.
- W4315433997 cites W1496790952 @default.
- W4315433997 cites W1521854746 @default.
- W4315433997 cites W1527671059 @default.
- W4315433997 cites W1542203808 @default.
- W4315433997 cites W1575298809 @default.
- W4315433997 cites W1598865329 @default.
- W4315433997 cites W1717443879 @default.
- W4315433997 cites W1835928992 @default.
- W4315433997 cites W1915536483 @default.
- W4315433997 cites W1965778124 @default.
- W4315433997 cites W1965888147 @default.
- W4315433997 cites W1968390598 @default.
- W4315433997 cites W1968996268 @default.
- W4315433997 cites W1969541118 @default.
- W4315433997 cites W1971065575 @default.
- W4315433997 cites W1973608140 @default.
- W4315433997 cites W1977044612 @default.
- W4315433997 cites W1979591162 @default.
- W4315433997 cites W1979783084 @default.
- W4315433997 cites W1984530097 @default.
- W4315433997 cites W1986040293 @default.
- W4315433997 cites W1986625112 @default.
- W4315433997 cites W1989913002 @default.
- W4315433997 cites W1990473626 @default.
- W4315433997 cites W1992241406 @default.
- W4315433997 cites W1993869272 @default.
- W4315433997 cites W1995191747 @default.
- W4315433997 cites W1997849090 @default.
- W4315433997 cites W1998385521 @default.
- W4315433997 cites W1999075862 @default.
- W4315433997 cites W2002404265 @default.
- W4315433997 cites W2005322339 @default.
- W4315433997 cites W2015932693 @default.
- W4315433997 cites W2019942048 @default.
- W4315433997 cites W2021977313 @default.
- W4315433997 cites W2022628342 @default.
- W4315433997 cites W2022649483 @default.
- W4315433997 cites W2022891079 @default.
- W4315433997 cites W2025373151 @default.
- W4315433997 cites W2026175550 @default.
- W4315433997 cites W2027649342 @default.
- W4315433997 cites W2041134571 @default.
- W4315433997 cites W2044141286 @default.
- W4315433997 cites W2047767243 @default.
- W4315433997 cites W2050786534 @default.
- W4315433997 cites W2051126370 @default.
- W4315433997 cites W2052029497 @default.
- W4315433997 cites W2055063567 @default.
- W4315433997 cites W2055874717 @default.
- W4315433997 cites W2063127941 @default.
- W4315433997 cites W2063690790 @default.
- W4315433997 cites W2064746087 @default.
- W4315433997 cites W2072427499 @default.
- W4315433997 cites W2075793841 @default.
- W4315433997 cites W2075832622 @default.
- W4315433997 cites W2078378216 @default.
- W4315433997 cites W2079286281 @default.
- W4315433997 cites W2079328277 @default.
- W4315433997 cites W2089607910 @default.
- W4315433997 cites W2089728480 @default.
- W4315433997 cites W2091265794 @default.
- W4315433997 cites W2096061603 @default.
- W4315433997 cites W2098985594 @default.
- W4315433997 cites W2106179404 @default.
- W4315433997 cites W2114628856 @default.
- W4315433997 cites W2117503265 @default.
- W4315433997 cites W2119582096 @default.
- W4315433997 cites W2121067042 @default.
- W4315433997 cites W2121977115 @default.
- W4315433997 cites W2123431154 @default.
- W4315433997 cites W2125553412 @default.
- W4315433997 cites W2125825438 @default.
- W4315433997 cites W2131769515 @default.
- W4315433997 cites W2132361192 @default.
- W4315433997 cites W2134886133 @default.
- W4315433997 cites W2143906078 @default.
- W4315433997 cites W2144737808 @default.
- W4315433997 cites W2145516262 @default.
- W4315433997 cites W2150656456 @default.
- W4315433997 cites W2154616452 @default.
- W4315433997 cites W2154717765 @default.
- W4315433997 cites W2156168338 @default.
- W4315433997 cites W2157102136 @default.
- W4315433997 cites W2160442779 @default.
- W4315433997 cites W2161334375 @default.
- W4315433997 cites W2162353774 @default.
- W4315433997 cites W2164546438 @default.
- W4315433997 cites W2170262356 @default.
- W4315433997 cites W2187596915 @default.
- W4315433997 cites W2237651852 @default.