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- W4315434325 endingPage "421" @default.
- W4315434325 startingPage "387" @default.
- W4315434325 abstract "Oncogenic transcription activation is associated with tumor development and resistance derived from chemotherapy or target therapy. The super elongation complex (SEC) is an important complex regulating gene transcription and expression in metazoans closely related to physiological activities. In normal transcriptional regulation, SEC can trigger promoter escape, limit proteolytic degradation of transcription elongation factors and increase the synthesis of RNA polymerase II (POL II), and regulate many normal human genes to stimulate RNA elongation. Dysregulation of SEC accompanied by multiple transcription factors in cancer promotes rapid transcription of oncogenes and induce cancer development. In this review, we summarized recent progress in understanding the mechanisms of SEC in regulating normal transcription, and importantly its roles in cancer development. We also highlighted the discovery of SEC complex target related inhibitors and their potential applications in cancer treatment." @default.
- W4315434325 created "2023-01-11" @default.
- W4315434325 creator A5005918792 @default.
- W4315434325 creator A5013059792 @default.
- W4315434325 creator A5073951267 @default.
- W4315434325 creator A5087892686 @default.
- W4315434325 date "2023-01-01" @default.
- W4315434325 modified "2023-10-11" @default.
- W4315434325 title "Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery" @default.
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