Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315436614> ?p ?o ?g. }
- W4315436614 endingPage "247" @default.
- W4315436614 startingPage "232" @default.
- W4315436614 abstract "VemR is a response regulator of the two-component signalling systems (TCSs). It consists solely of a receiver domain. Previous studies have shown that VemR plays an important role in influencing the production of exopolysaccharides and exoenzymes, cell motility, and virulence of Xanthomonas campestris pv. campestris (Xcc). However, whether VemR is involved in the essential pathogenicity determinant type III secretion system (T3SS) is unclear. In this work, we found by transcriptome analysis that VemR modulates about 10% of Xcc genes, which are involved in various cellular processes including the T3SS. Further experiments revealed that VemR physically interacts with numerous proteins, including the TCS sensor kinases HpaS and RavA, and the TCS response regulator HrpG, which directly activates the transcription of HrpX, a key regulator controlling T3SS expression. It has been demonstrated previously that HpaS composes a TCS with HrpG or VemR to control the expression of T3SS or swimming motility, while RavA and VemR form a TCS to control the expression of flagellar genes. Mutation analysis and in vitro transcription assay revealed that phosphorylation might be essential for the function of VemR and phosphorylated VemR could significantly enhance the activation of hrpX transcription by HrpG. We infer that the binding of VemR to HrpG can modulate the activity of HrpG to the hrpX promoter, thereby enhancing hrpX transcription. Although further studies are required to validate this inference and explore the detailed functional mechanism of VemR, our findings provide some insights into the complex regulatory cascade of the HpaS/RavA-VemR/HrpG-HrpX signal transduction system in the control of T3SS." @default.
- W4315436614 created "2023-01-11" @default.
- W4315436614 creator A5028433300 @default.
- W4315436614 creator A5042441651 @default.
- W4315436614 creator A5055620251 @default.
- W4315436614 creator A5056458404 @default.
- W4315436614 creator A5066839346 @default.
- W4315436614 creator A5075459252 @default.
- W4315436614 creator A5081356585 @default.
- W4315436614 date "2023-01-10" @default.
- W4315436614 modified "2023-10-17" @default.
- W4315436614 title "<i>Xanthomonas campestris</i> VemR enhances the transcription of the T3SS key regulator HrpX via physical interaction with HrpG" @default.
- W4315436614 cites W1569556046 @default.
- W4315436614 cites W1598716882 @default.
- W4315436614 cites W1730105450 @default.
- W4315436614 cites W1773772761 @default.
- W4315436614 cites W1968727934 @default.
- W4315436614 cites W1970861164 @default.
- W4315436614 cites W1986062131 @default.
- W4315436614 cites W1991386041 @default.
- W4315436614 cites W1993497391 @default.
- W4315436614 cites W2012347905 @default.
- W4315436614 cites W2015257671 @default.
- W4315436614 cites W2037261093 @default.
- W4315436614 cites W2050294818 @default.
- W4315436614 cites W2066203685 @default.
- W4315436614 cites W2067464792 @default.
- W4315436614 cites W2073690728 @default.
- W4315436614 cites W2074279517 @default.
- W4315436614 cites W2083023732 @default.
- W4315436614 cites W2096730875 @default.
- W4315436614 cites W2120698877 @default.
- W4315436614 cites W2121672428 @default.
- W4315436614 cites W2122609980 @default.
- W4315436614 cites W2123571266 @default.
- W4315436614 cites W2124031945 @default.
- W4315436614 cites W2133865221 @default.
- W4315436614 cites W2151319142 @default.
- W4315436614 cites W2152786904 @default.
- W4315436614 cites W2153076508 @default.
- W4315436614 cites W2158326536 @default.
- W4315436614 cites W2326981264 @default.
- W4315436614 cites W24219159 @default.
- W4315436614 cites W2423764880 @default.
- W4315436614 cites W2474493099 @default.
- W4315436614 cites W2793390638 @default.
- W4315436614 cites W2887888588 @default.
- W4315436614 cites W2898198931 @default.
- W4315436614 cites W2924932674 @default.
- W4315436614 cites W2949452547 @default.
- W4315436614 cites W2977627461 @default.
- W4315436614 cites W2999450422 @default.
- W4315436614 cites W3000373060 @default.
- W4315436614 cites W3117986865 @default.
- W4315436614 cites W3214991979 @default.
- W4315436614 cites W3215570076 @default.
- W4315436614 cites W4213025499 @default.
- W4315436614 cites W4232048522 @default.
- W4315436614 cites W4282020334 @default.
- W4315436614 cites W4315436614 @default.
- W4315436614 cites W56081268 @default.
- W4315436614 cites W803963015 @default.
- W4315436614 doi "https://doi.org/10.1111/mpp.13293" @default.
- W4315436614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36626275" @default.
- W4315436614 hasPublicationYear "2023" @default.
- W4315436614 type Work @default.
- W4315436614 citedByCount "1" @default.
- W4315436614 countsByYear W43154366142023 @default.
- W4315436614 crossrefType "journal-article" @default.
- W4315436614 hasAuthorship W4315436614A5028433300 @default.
- W4315436614 hasAuthorship W4315436614A5042441651 @default.
- W4315436614 hasAuthorship W4315436614A5055620251 @default.
- W4315436614 hasAuthorship W4315436614A5056458404 @default.
- W4315436614 hasAuthorship W4315436614A5066839346 @default.
- W4315436614 hasAuthorship W4315436614A5075459252 @default.
- W4315436614 hasAuthorship W4315436614A5081356585 @default.
- W4315436614 hasBestOaLocation W43154366141 @default.
- W4315436614 hasConcept C104317684 @default.
- W4315436614 hasConcept C119062480 @default.
- W4315436614 hasConcept C130211564 @default.
- W4315436614 hasConcept C143065580 @default.
- W4315436614 hasConcept C158617107 @default.
- W4315436614 hasConcept C206052861 @default.
- W4315436614 hasConcept C2780679087 @default.
- W4315436614 hasConcept C2780746887 @default.
- W4315436614 hasConcept C2781196521 @default.
- W4315436614 hasConcept C51785407 @default.
- W4315436614 hasConcept C54355233 @default.
- W4315436614 hasConcept C60987743 @default.
- W4315436614 hasConcept C6929976 @default.
- W4315436614 hasConcept C86339819 @default.
- W4315436614 hasConcept C86803240 @default.
- W4315436614 hasConcept C95444343 @default.
- W4315436614 hasConceptScore W4315436614C104317684 @default.
- W4315436614 hasConceptScore W4315436614C119062480 @default.
- W4315436614 hasConceptScore W4315436614C130211564 @default.
- W4315436614 hasConceptScore W4315436614C143065580 @default.
- W4315436614 hasConceptScore W4315436614C158617107 @default.