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- W4315436615 abstract "Preterm birth results in low nephron endowment and increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). To understand the pathogenesis of AKI and CKD in preterm humans, we generated potentially novel mouse models with a 30%–70% reduction in nephron number by inhibiting or deleting Ret tyrosine kinase in the developing ureteric bud. These mice developed glomerular and tubular hypertrophy, followed by the transition to CKD, recapitulating the renal pathological changes seen in humans born preterm. We injected neonatal mice with gentamicin, a ubiquitous nephrotoxic exposure in preterm infants, and detected more severe proximal tubular injury in mice with low nephron number compared with controls with normal nephron number. Mice with low nephron number had reduced proliferative repair with more rapid development of CKD. Furthermore, mice had more profound inflammation with highly elevated levels of MCP-1 and CXCL10, produced in part by damaged proximal tubules. Our study directly links low nephron endowment with postnatal renal hypertrophy, which in this model is maladaptive and results in CKD. Underdeveloped kidneys are more susceptible to gentamicin-induced AKI, suggesting that AKI in the setting of low nephron number is more severe and further increases the risk of CKD in this vulnerable population." @default.
- W4315436615 created "2023-01-11" @default.
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- W4315436615 date "2023-02-08" @default.
- W4315436615 modified "2023-09-27" @default.
- W4315436615 title "Low nephron endowment increases susceptibility to renal stress and chronic kidney disease" @default.
- W4315436615 cites W148052990 @default.
- W4315436615 cites W1502534219 @default.
- W4315436615 cites W1520738779 @default.
- W4315436615 cites W1540014973 @default.
- W4315436615 cites W1557516386 @default.
- W4315436615 cites W1590233037 @default.
- W4315436615 cites W1600041836 @default.
- W4315436615 cites W1744619657 @default.
- W4315436615 cites W1912153606 @default.
- W4315436615 cites W1933241387 @default.
- W4315436615 cites W1966772525 @default.
- W4315436615 cites W1974005261 @default.
- W4315436615 cites W1974566062 @default.
- W4315436615 cites W1980647554 @default.
- W4315436615 cites W1990207644 @default.
- W4315436615 cites W1991607910 @default.
- W4315436615 cites W1993363519 @default.
- W4315436615 cites W1995338323 @default.
- W4315436615 cites W1996055704 @default.
- W4315436615 cites W1996416783 @default.
- W4315436615 cites W1997721810 @default.
- W4315436615 cites W1998029792 @default.
- W4315436615 cites W1999693507 @default.
- W4315436615 cites W2003370392 @default.
- W4315436615 cites W2003581940 @default.
- W4315436615 cites W2004560219 @default.
- W4315436615 cites W2004881323 @default.
- W4315436615 cites W2009968854 @default.
- W4315436615 cites W2018091219 @default.
- W4315436615 cites W2018445507 @default.
- W4315436615 cites W2019797824 @default.
- W4315436615 cites W2021448292 @default.
- W4315436615 cites W2021713115 @default.
- W4315436615 cites W2021988356 @default.
- W4315436615 cites W2024090733 @default.
- W4315436615 cites W2028031291 @default.
- W4315436615 cites W2033829367 @default.
- W4315436615 cites W2035155691 @default.
- W4315436615 cites W2038479789 @default.
- W4315436615 cites W2041426570 @default.
- W4315436615 cites W2041856436 @default.
- W4315436615 cites W2046021057 @default.
- W4315436615 cites W2046208657 @default.
- W4315436615 cites W2047632739 @default.
- W4315436615 cites W2052248511 @default.
- W4315436615 cites W2056906256 @default.
- W4315436615 cites W2062868035 @default.
- W4315436615 cites W2068050227 @default.
- W4315436615 cites W2069074157 @default.
- W4315436615 cites W2072954278 @default.
- W4315436615 cites W2077967941 @default.
- W4315436615 cites W2079079821 @default.
- W4315436615 cites W2081523875 @default.
- W4315436615 cites W2083816327 @default.
- W4315436615 cites W2084176144 @default.
- W4315436615 cites W2095643982 @default.
- W4315436615 cites W2097461167 @default.
- W4315436615 cites W2098473544 @default.
- W4315436615 cites W2105946812 @default.
- W4315436615 cites W2117036407 @default.
- W4315436615 cites W2120073512 @default.
- W4315436615 cites W2125296976 @default.
- W4315436615 cites W2125995351 @default.
- W4315436615 cites W2135854842 @default.
- W4315436615 cites W2139020475 @default.
- W4315436615 cites W2139872889 @default.
- W4315436615 cites W2140950633 @default.
- W4315436615 cites W2146183794 @default.
- W4315436615 cites W2148372988 @default.
- W4315436615 cites W2149008631 @default.
- W4315436615 cites W2152910359 @default.
- W4315436615 cites W2155426373 @default.
- W4315436615 cites W2157202055 @default.
- W4315436615 cites W2163146547 @default.
- W4315436615 cites W2164236630 @default.
- W4315436615 cites W2166234655 @default.
- W4315436615 cites W2220742453 @default.
- W4315436615 cites W2264139579 @default.
- W4315436615 cites W2282517414 @default.
- W4315436615 cites W2321882376 @default.
- W4315436615 cites W2326729106 @default.
- W4315436615 cites W2410139705 @default.
- W4315436615 cites W2414416918 @default.
- W4315436615 cites W2419906038 @default.