FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315437030> ?p ?o ?g. }

• W4315437030 abstract "Previous observational studies showed higher rates of abdominal wall closure with the use of hypertonic saline in trauma patients with abdominal injuries. However, no randomized controlled trials have been performed on this matter. This double-blind randomized clinical trial assessed the effect of 3% hypertonic saline (HS) solution on primary fascial closure and the timing of abdominal wall closure among patients who underwent damage control laparotomy for bleeding control.Double-blind randomized clinical trial. Patients with abdominal injuries requiring damage control laparotomy (DCL) were randomly allocated to receive a 72-h infusion (rate: 50 mL/h) of 3% HS or 0.9 N isotonic saline (NS) after the index DCL. The primary endpoint was the proportion of patients with abdominal wall closure in the first seven days after the index DCL.The study was suspended in the first interim analysis because of futility. A total of 52 patients were included. Of these, 27 and 25 were randomly allocated to NS and HS, respectively. There were no significant differences in the rates of abdominal wall closure between groups (HS: 19 [79.2%] vs. NS: 17 [70.8%]; p = 0.71). In contrast, significantly higher hypernatremia rates were observed in the HS group (HS: 11 [44%] vs. NS: 1 [3.7%]; p < 0.001).This double-blind randomized clinical trial showed no benefit of HS solution in primary fascial closure rates. Patients randomized to HS had higher sodium concentrations after the first day and were more likely to present hypernatremia. We do not recommend using HS in patients undergoing damage control laparotomy. Trial registration The trial protocol was registered in clinicaltrials.gov (identifier: NCT02542241)." @default.
• W4315437030 created "2023-01-11" @default.
• W4315437030 creator A5001688858 @default.
• W4315437030 creator A5009454355 @default.
• W4315437030 creator A5020064929 @default.
• W4315437030 creator A5028729239 @default.
• W4315437030 creator A5031880576 @default.
• W4315437030 creator A5054555078 @default.
• W4315437030 creator A5056497705 @default.
• W4315437030 creator A5063102428 @default.
• W4315437030 creator A5064690507 @default.
• W4315437030 creator A5070927466 @default.
• W4315437030 creator A5087628395 @default.
• W4315437030 date "2023-01-09" @default.
• W4315437030 modified "2023-10-09" @default.
• W4315437030 title "Hypertonic saline infusion does not improve the chance of primary fascial closure after damage control laparotomy: a randomized controlled trial" @default.
• W4315437030 cites W1551781691 @default.
• W4315437030 cites W1691186793 @default.
• W4315437030 cites W1803784511 @default.
• W4315437030 cites W1968817382 @default.
• W4315437030 cites W1988953288 @default.
• W4315437030 cites W1991864206 @default.
• W4315437030 cites W1992192396 @default.
• W4315437030 cites W2003120731 @default.
• W4315437030 cites W2011356417 @default.
• W4315437030 cites W2013256551 @default.
• W4315437030 cites W2019909594 @default.
• W4315437030 cites W2028564991 @default.
• W4315437030 cites W2037719820 @default.
• W4315437030 cites W2042109117 @default.
• W4315437030 cites W2056208640 @default.
• W4315437030 cites W2059707463 @default.
• W4315437030 cites W2086996788 @default.
• W4315437030 cites W2089752148 @default.
• W4315437030 cites W2115625702 @default.
• W4315437030 cites W2464560133 @default.
• W4315437030 cites W2559929606 @default.
• W4315437030 cites W2561982390 @default.
• W4315437030 cites W2581421338 @default.
• W4315437030 cites W2620241325 @default.
• W4315437030 cites W2665746724 @default.
• W4315437030 cites W2754500623 @default.
• W4315437030 cites W2768210694 @default.
• W4315437030 cites W2904932776 @default.
• W4315437030 cites W3212061091 @default.
• W4315437030 cites W3216639550 @default.
• W4315437030 cites W3217461059 @default.
• W4315437030 cites W4289335677 @default.
• W4315437030 cites W4293108385 @default.
• W4315437030 doi "https://doi.org/10.1186/s13017-023-00475-x" @default.
• W4315437030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36624448" @default.
• W4315437030 hasPublicationYear "2023" @default.
• W4315437030 type Work @default.
• W4315437030 citedByCount "1" @default.
• W4315437030 countsByYear W43154370302023 @default.
• W4315437030 crossrefType "journal-article" @default.
• W4315437030 hasAuthorship W4315437030A5001688858 @default.
• W4315437030 hasAuthorship W4315437030A5009454355 @default.
• W4315437030 hasAuthorship W4315437030A5020064929 @default.
• W4315437030 hasAuthorship W4315437030A5028729239 @default.
• W4315437030 hasAuthorship W4315437030A5031880576 @default.
• W4315437030 hasAuthorship W4315437030A5054555078 @default.
• W4315437030 hasAuthorship W4315437030A5056497705 @default.
• W4315437030 hasAuthorship W4315437030A5063102428 @default.
• W4315437030 hasAuthorship W4315437030A5064690507 @default.
• W4315437030 hasAuthorship W4315437030A5070927466 @default.
• W4315437030 hasAuthorship W4315437030A5087628395 @default.
• W4315437030 hasBestOaLocation W43154370301 @default.
• W4315437030 hasConcept C141071460 @default.
• W4315437030 hasConcept C168563851 @default.
• W4315437030 hasConcept C178790620 @default.
• W4315437030 hasConcept C185592680 @default.
• W4315437030 hasConcept C203092338 @default.
• W4315437030 hasConcept C2777397205 @default.
• W4315437030 hasConcept C2778864100 @default.
• W4315437030 hasConcept C2780778865 @default.
• W4315437030 hasConcept C3017567848 @default.
• W4315437030 hasConcept C42219234 @default.
• W4315437030 hasConcept C537181965 @default.
• W4315437030 hasConcept C71924100 @default.
• W4315437030 hasConceptScore W4315437030C141071460 @default.
• W4315437030 hasConceptScore W4315437030C168563851 @default.
• W4315437030 hasConceptScore W4315437030C178790620 @default.
• W4315437030 hasConceptScore W4315437030C185592680 @default.
• W4315437030 hasConceptScore W4315437030C203092338 @default.
• W4315437030 hasConceptScore W4315437030C2777397205 @default.
• W4315437030 hasConceptScore W4315437030C2778864100 @default.
• W4315437030 hasConceptScore W4315437030C2780778865 @default.
• W4315437030 hasConceptScore W4315437030C3017567848 @default.
• W4315437030 hasConceptScore W4315437030C42219234 @default.
• W4315437030 hasConceptScore W4315437030C537181965 @default.
• W4315437030 hasConceptScore W4315437030C71924100 @default.
• W4315437030 hasIssue "1" @default.
• W4315437030 hasLocation W43154370301 @default.
• W4315437030 hasLocation W43154370302 @default.
• W4315437030 hasLocation W43154370303 @default.
• W4315437030 hasOpenAccess W4315437030 @default.
• W4315437030 hasPrimaryLocation W43154370301 @default.
• W4315437030 hasRelatedWork W1994357441 @default.
• W4315437030 hasRelatedWork W2469208661 @default.

• next