FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315476271> ?p ?o ?g. }

• W4315476271 endingPage "69" @default.
• W4315476271 startingPage "53" @default.
• W4315476271 abstract "microRNAs (miRNAs) are involved in the progression of Lung adenocarcinoma (LUAD), however, the functions of miR-6742-5p in LUAD remains unknown, thereby this study was carried on.The mRNA and miRNA expression data from the LUAD and normal control were obtained from Gene Expression Omnibus (GEO) database, TargetScan and mirDIP were applied to predict the relationship between miR-6742-5p and FGF8.Q-PCR, western blot, dual-luciferase, wound Healing and transwell assays were performed to test the functions of miR-6742-5p in LUAD.Bioinformatics analysis and dual-luciferase identified FGF8 is the target-gene of miR-6742-5p, which is declined in LUAD of human tissues and cell lines, and miR-6742-5P OE suppressed the progression of LUAD in nude mice. MiR-6742-5p OE and KD suppressed or increased the abilities of LUAD' metastasis tested by wound healing and transwell assays H522 and PC-9 cells, these effects about miR-6742-5p OE were reversed by FGF8; miR-6742-5p OE, KD inhibited and increased the expression of FGF8 as its downstream p-ERK1/2, MMP-2/-9, these results were corrected by ERK1/2 inhibitor: Ro 67-7476; the miR-6742-5p KD increased the migrated and invaded cells and suppressed by MMPs inhibitor: S3304. These results identified the negative correlation of miR-6742-5p with FGF8-ERK1/2 signal pathway in LUAD progression.We conclude that miR-6742-5p might be a regulator of LUAD progression by targeting FGF8/ERK1/2/MMPs signaling pathway, which provides a novel therapeutic target for LUAD." @default.
• W4315476271 created "2023-01-11" @default.
• W4315476271 creator A5028529893 @default.
• W4315476271 creator A5032822273 @default.
• W4315476271 date "2023-01-10" @default.
• W4315476271 modified "2023-09-30" @default.
• W4315476271 title "miR-6742-5p regulates the invasion and migration of lung adenocarcinoma cells via mediating FGF8/ERK12/MMP9/MMP2 signaling pathway" @default.
• W4315476271 cites W1488150536 @default.
• W4315476271 cites W1744683414 @default.
• W4315476271 cites W1880324554 @default.
• W4315476271 cites W1964939988 @default.
• W4315476271 cites W2007185132 @default.
• W4315476271 cites W2088482860 @default.
• W4315476271 cites W2124988709 @default.
• W4315476271 cites W2467123328 @default.
• W4315476271 cites W2736208993 @default.
• W4315476271 cites W2755469056 @default.
• W4315476271 cites W2789436467 @default.
• W4315476271 cites W2807032285 @default.
• W4315476271 cites W2808405179 @default.
• W4315476271 cites W2876850598 @default.
• W4315476271 cites W2886653898 @default.
• W4315476271 cites W2895006944 @default.
• W4315476271 cites W2920813348 @default.
• W4315476271 cites W2974116654 @default.
• W4315476271 cites W2996341263 @default.
• W4315476271 cites W2997095491 @default.
• W4315476271 cites W2998562464 @default.
• W4315476271 cites W2999417355 @default.
• W4315476271 cites W3007917119 @default.
• W4315476271 cites W3015990730 @default.
• W4315476271 cites W3016861822 @default.
• W4315476271 cites W3021645531 @default.
• W4315476271 cites W3022292509 @default.
• W4315476271 cites W3025850379 @default.
• W4315476271 cites W3027820694 @default.
• W4315476271 cites W3033160274 @default.
• W4315476271 cites W3037970867 @default.
• W4315476271 cites W3040688214 @default.
• W4315476271 cites W3049420384 @default.
• W4315476271 cites W3089652036 @default.
• W4315476271 cites W3110787788 @default.
• W4315476271 cites W3113462936 @default.
• W4315476271 cites W3123906991 @default.
• W4315476271 cites W3129038946 @default.
• W4315476271 cites W3165650933 @default.
• W4315476271 cites W3212211655 @default.
• W4315476271 cites W3216628479 @default.
• W4315476271 cites W4200597752 @default.
• W4315476271 doi "https://doi.org/10.18632/aging.204277" @default.
• W4315476271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36629518" @default.
• W4315476271 hasPublicationYear "2023" @default.
• W4315476271 type Work @default.
• W4315476271 citedByCount "1" @default.
• W4315476271 countsByYear W43154762712023 @default.
• W4315476271 crossrefType "journal-article" @default.
• W4315476271 hasAuthorship W4315476271A5028529893 @default.
• W4315476271 hasAuthorship W4315476271A5032822273 @default.
• W4315476271 hasBestOaLocation W43154762711 @default.
• W4315476271 hasConcept C104317684 @default.
• W4315476271 hasConcept C121608353 @default.
• W4315476271 hasConcept C127561419 @default.
• W4315476271 hasConcept C145059251 @default.
• W4315476271 hasConcept C153911025 @default.
• W4315476271 hasConcept C170493617 @default.
• W4315476271 hasConcept C2775997469 @default.
• W4315476271 hasConcept C2776094402 @default.
• W4315476271 hasConcept C2779013556 @default.
• W4315476271 hasConcept C2780699576 @default.
• W4315476271 hasConcept C2781182431 @default.
• W4315476271 hasConcept C502942594 @default.
• W4315476271 hasConcept C54355233 @default.
• W4315476271 hasConcept C62478195 @default.
• W4315476271 hasConcept C74373430 @default.
• W4315476271 hasConcept C86803240 @default.
• W4315476271 hasConcept C95444343 @default.
• W4315476271 hasConceptScore W4315476271C104317684 @default.
• W4315476271 hasConceptScore W4315476271C121608353 @default.
• W4315476271 hasConceptScore W4315476271C127561419 @default.
• W4315476271 hasConceptScore W4315476271C145059251 @default.
• W4315476271 hasConceptScore W4315476271C153911025 @default.
• W4315476271 hasConceptScore W4315476271C170493617 @default.
• W4315476271 hasConceptScore W4315476271C2775997469 @default.
• W4315476271 hasConceptScore W4315476271C2776094402 @default.
• W4315476271 hasConceptScore W4315476271C2779013556 @default.
• W4315476271 hasConceptScore W4315476271C2780699576 @default.
• W4315476271 hasConceptScore W4315476271C2781182431 @default.
• W4315476271 hasConceptScore W4315476271C502942594 @default.
• W4315476271 hasConceptScore W4315476271C54355233 @default.
• W4315476271 hasConceptScore W4315476271C62478195 @default.
• W4315476271 hasConceptScore W4315476271C74373430 @default.
• W4315476271 hasConceptScore W4315476271C86803240 @default.
• W4315476271 hasConceptScore W4315476271C95444343 @default.
• W4315476271 hasIssue "1" @default.
• W4315476271 hasLocation W43154762711 @default.
• W4315476271 hasLocation W43154762712 @default.
• W4315476271 hasLocation W43154762713 @default.
• W4315476271 hasOpenAccess W4315476271 @default.

• next