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• W4315478085 abstract "Abstract Purpose: Diabetes is a risk factor that predisposes to atherosclerotic cardiovascular diseases. The risk of myocardial infarction in diabetes is 3-4 times higher. In diabetes, high blood glucose levels lead to vascular inflammation which accelerates atherosclerosis. Hence, we evaluate the mechanism involved in the cardioprotective action of Morin in diabetic rats. Methods: In male Wistar rats, streptozotocin (70 mg/kg; i.p.) was administered to induce diabetes and, rats with fasting blood glucose levels >400 mg/dl were considered diabetic and included in the study. These rats were divided into five groups (n=8), i.e., Normal; Diabetic-control; Diabetes+Isoproterenol (ISO); Diabetes+ISO+Morin and, Diabetes+Morin. Morin was orally administered at the dose of 40 mg/kg for 28 days and on the 27 th and 28 th day ISO was administered to designate groups at the dose of 85mg/kg s.c., to induce myocardial infarction. Results: Free radical generation in diabetes as well as the rush of ROS following ISO administration leads to activation of the intrinsic as well as extrinsic pathways of apoptosis. Morin significantly (p≤0.05) reduced oxidative stress (áGSH, âMDA, áSOD), cardiac injury markers (âCK-MB, âLDH), inflammation (âTNF, âIL-6) and apoptosis (âBax, áBCl 2 , áCaspase-3). In addition, it also reduced serum insulin and blood glucose levels. Histopathology showed cardio-protection with morin. Akt/eNOS, Nrf2/HO-1, MAPK signalling pathways and Insulin signal transduction pathways were positively modulated by Morin pre-treatment. It also significantly modulated NLRP3 inflammasome formation. Conclusion : Morin attenuated oxidative stress and inflammation and also modified expression of various molecular pathways to mitigate cardiomyocyte damage during ISO induced MI in diabetic rats." @default.
• W4315478085 created "2023-01-11" @default.
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• W4315478085 date "2023-01-10" @default.
• W4315478085 modified "2023-09-25" @default.
• W4315478085 title "Modulation of MAPK/Nrf2-HO1/Akt-eNOS/inflammasome pathways by morin in myocardial infarction in diabetic rats" @default.
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• W4315478085 doi "https://doi.org/10.21203/rs.3.rs-2444264/v1" @default.
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