FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315479855> ?p ?o ?g. }

• W4315479855 abstract "Down syndrome (DS), the most frequent chromosomic aberration, results from the presence of an extra copy of chromosome 21. The identification of genes which overexpression contributes to intellectual disability (ID) in DS is important to understand the pathophysiological mechanisms involved and develop new pharmacological therapies. In particular, gene dosage of Dual specificity tyrosine phosphorylation Regulated Kinase 1A ( DYRK1A ) and of Cystathionine beta synthase ( CBS ) are crucial for cognitive function. As these two enzymes have lately been the main targets for therapeutic research on ID, we sought to decipher the genetic relationship between them. We also used a combination of genetic and drug screenings using a cellular model overexpressing CYS4 , the homolog of CBS in Saccharomyces cerevisiae , to get further insights into the molecular mechanisms involved in the regulation of CBS activity. We showed that overexpression of YAK1 , the homolog of DYRK1A in yeast, increased CYS4 activity whereas GSK3 β was identified as a genetic suppressor of CBS . In addition, analysis of the signaling pathways targeted by the drugs identified through the yeast-based pharmacological screening, and confirmed using human HepG2 cells, emphasized the importance of Akt/GSK3β and NF-κB pathways into the regulation of CBS activity and expression. Taken together, these data provide further understanding into the regulation of CBS and in particular into the genetic relationship between DYRK1A and CBS through the Akt/GSK3β and NF-κB pathways, which should help develop more effective therapies to reduce cognitive deficits in people with DS." @default.
• W4315479855 created "2023-01-11" @default.
• W4315479855 creator A5022877478 @default.
• W4315479855 creator A5030990011 @default.
• W4315479855 creator A5032364845 @default.
• W4315479855 creator A5042412913 @default.
• W4315479855 creator A5042530464 @default.
• W4315479855 creator A5042858067 @default.
• W4315479855 creator A5065534875 @default.
• W4315479855 creator A5067175412 @default.
• W4315479855 creator A5070268840 @default.
• W4315479855 creator A5071716642 @default.
• W4315479855 date "2023-01-09" @default.
• W4315479855 modified "2023-10-05" @default.
• W4315479855 title "New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome" @default.
• W4315479855 cites W1517210188 @default.
• W4315479855 cites W1617532721 @default.
• W4315479855 cites W1674148475 @default.
• W4315479855 cites W1963875364 @default.
• W4315479855 cites W1966072209 @default.
• W4315479855 cites W1972441901 @default.
• W4315479855 cites W1976539175 @default.
• W4315479855 cites W1978656205 @default.
• W4315479855 cites W1980342220 @default.
• W4315479855 cites W1980473900 @default.
• W4315479855 cites W1997948920 @default.
• W4315479855 cites W1999148207 @default.
• W4315479855 cites W2001889323 @default.
• W4315479855 cites W2005741564 @default.
• W4315479855 cites W2005980540 @default.
• W4315479855 cites W2006430331 @default.
• W4315479855 cites W2012233157 @default.
• W4315479855 cites W2013082566 @default.
• W4315479855 cites W2015529097 @default.
• W4315479855 cites W2017178616 @default.
• W4315479855 cites W2018237527 @default.
• W4315479855 cites W2020902432 @default.
• W4315479855 cites W2021268395 @default.
• W4315479855 cites W2022582116 @default.
• W4315479855 cites W2027774159 @default.
• W4315479855 cites W2028903560 @default.
• W4315479855 cites W2029326990 @default.
• W4315479855 cites W2031441432 @default.
• W4315479855 cites W2032189684 @default.
• W4315479855 cites W2033638681 @default.
• W4315479855 cites W2034184579 @default.
• W4315479855 cites W2036612423 @default.
• W4315479855 cites W2040205108 @default.
• W4315479855 cites W2041435108 @default.
• W4315479855 cites W2042388217 @default.
• W4315479855 cites W2043271362 @default.
• W4315479855 cites W2045208621 @default.
• W4315479855 cites W2048270386 @default.
• W4315479855 cites W2048722408 @default.
• W4315479855 cites W2048732917 @default.
• W4315479855 cites W2051685982 @default.
• W4315479855 cites W2057753192 @default.
• W4315479855 cites W2058610193 @default.
• W4315479855 cites W2061725326 @default.
• W4315479855 cites W2063092087 @default.
• W4315479855 cites W2069389312 @default.
• W4315479855 cites W2075619210 @default.
• W4315479855 cites W2082062618 @default.
• W4315479855 cites W2082498929 @default.
• W4315479855 cites W2086104744 @default.
• W4315479855 cites W2094573922 @default.
• W4315479855 cites W2102062854 @default.
• W4315479855 cites W2107283345 @default.
• W4315479855 cites W2116893918 @default.
• W4315479855 cites W2118394016 @default.
• W4315479855 cites W2122723613 @default.
• W4315479855 cites W2143873823 @default.
• W4315479855 cites W2146893766 @default.
• W4315479855 cites W2148973620 @default.
• W4315479855 cites W2149048480 @default.
• W4315479855 cites W2155556919 @default.
• W4315479855 cites W2156776764 @default.
• W4315479855 cites W2158742765 @default.
• W4315479855 cites W2164590207 @default.
• W4315479855 cites W2189645607 @default.
• W4315479855 cites W2329640861 @default.
• W4315479855 cites W2401943269 @default.
• W4315479855 cites W2405004189 @default.
• W4315479855 cites W2413465592 @default.
• W4315479855 cites W2460898987 @default.
• W4315479855 cites W2499620239 @default.
• W4315479855 cites W2507879231 @default.
• W4315479855 cites W2525275385 @default.
• W4315479855 cites W2554623469 @default.
• W4315479855 cites W2561475925 @default.
• W4315479855 cites W2725779950 @default.
• W4315479855 cites W2726190435 @default.
• W4315479855 cites W2752797455 @default.
• W4315479855 cites W2765103123 @default.
• W4315479855 cites W2796873125 @default.
• W4315479855 cites W2799855820 @default.
• W4315479855 cites W2887515249 @default.
• W4315479855 cites W2888195702 @default.
• W4315479855 cites W2890291824 @default.
• W4315479855 cites W2892980924 @default.

• next