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• W4315489925 abstract "There is growing recognition that regionalization of bacterial colonization and immunity along the intestinal tract has an important role in health and disease. Yet, the mechanisms underlying intestinal regionalization and its dysregulation in disease are not well understood. This study found that regional epithelial expression of the transcription factor GATA4 controls bacterial colonization and inflammatory tissue immunity in the proximal small intestine by regulating retinol metabolism and luminal IgA. Furthermore, in mice without jejunal GATA4 expression, the commensal segmented filamentous bacteria promoted pathogenic inflammatory immune responses that disrupted barrier function and increased mortality upon Citrobacter rodentium infection. In celiac disease patients, low GATA4 expression was associated with metabolic alterations, mucosal Actinobacillus, and increased IL-17 immunity. Taken together, these results reveal broad impacts of GATA4-regulated intestinal regionalization on bacterial colonization and tissue immunity, highlighting an elaborate interdependence of intestinal metabolism, immunity, and microbiota in homeostasis and disease." @default.
• W4315489925 created "2023-01-11" @default.
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• W4315489925 date "2023-01-01" @default.
• W4315489925 modified "2023-10-17" @default.
• W4315489925 title "GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology" @default.
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• W4315489925 cites W1701869895 @default.
• W4315489925 cites W1773874353 @default.
• W4315489925 cites W1885357042 @default.
• W4315489925 cites W1888761419 @default.
• W4315489925 cites W1902150932 @default.
• W4315489925 cites W1923040793 @default.
• W4315489925 cites W1965301687 @default.
• W4315489925 cites W1972135944 @default.
• W4315489925 cites W1978025022 @default.
• W4315489925 cites W1978878058 @default.
• W4315489925 cites W1979217507 @default.
• W4315489925 cites W1983541741 @default.
• W4315489925 cites W1984771489 @default.
• W4315489925 cites W1990473825 @default.
• W4315489925 cites W1991473719 @default.
• W4315489925 cites W1994875855 @default.
• W4315489925 cites W2006194008 @default.
• W4315489925 cites W2008909492 @default.
• W4315489925 cites W2034285706 @default.
• W4315489925 cites W2035618305 @default.
• W4315489925 cites W2043659905 @default.
• W4315489925 cites W2048814693 @default.
• W4315489925 cites W2050417626 @default.
• W4315489925 cites W2054539653 @default.
• W4315489925 cites W2060887139 @default.
• W4315489925 cites W2065214355 @default.
• W4315489925 cites W2067320696 @default.
• W4315489925 cites W2069078105 @default.
• W4315489925 cites W2072865199 @default.
• W4315489925 cites W2076540892 @default.
• W4315489925 cites W2079633519 @default.
• W4315489925 cites W2085429049 @default.
• W4315489925 cites W2090364972 @default.
• W4315489925 cites W2092648379 @default.
• W4315489925 cites W2100548379 @default.
• W4315489925 cites W2101403111 @default.
• W4315489925 cites W2103017472 @default.
• W4315489925 cites W2107369528 @default.
• W4315489925 cites W2111731663 @default.
• W4315489925 cites W2118455790 @default.
• W4315489925 cites W2131271579 @default.
• W4315489925 cites W2134526812 @default.
• W4315489925 cites W2144206275 @default.
• W4315489925 cites W2144693556 @default.
• W4315489925 cites W2146100358 @default.
• W4315489925 cites W2146512944 @default.
• W4315489925 cites W2151464048 @default.
• W4315489925 cites W2159707944 @default.
• W4315489925 cites W2161789287 @default.
• W4315489925 cites W2164848453 @default.
• W4315489925 cites W2165183959 @default.
• W4315489925 cites W2169456326 @default.
• W4315489925 cites W2179438025 @default.
• W4315489925 cites W2182802799 @default.
• W4315489925 cites W2214074259 @default.
• W4315489925 cites W2301342743 @default.
• W4315489925 cites W2323326409 @default.
• W4315489925 cites W2329639007 @default.
• W4315489925 cites W2406250479 @default.
• W4315489925 cites W2408135904 @default.
• W4315489925 cites W2558219863 @default.
• W4315489925 cites W2580349738 @default.
• W4315489925 cites W2592244930 @default.
• W4315489925 cites W2626087669 @default.
• W4315489925 cites W2759933576 @default.
• W4315489925 cites W2770308076 @default.
• W4315489925 cites W2786985471 @default.
• W4315489925 cites W2792468812 @default.
• W4315489925 cites W2800593054 @default.
• W4315489925 cites W2912947431 @default.
• W4315489925 cites W2917614594 @default.
• W4315489925 cites W2921973674 @default.

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