FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315564879> ?p ?o ?g. }

• W4315564879 abstract "Infectious bursal disease (IBD), caused by infectious bursal disease virus (IBDV), is one among the top five infectious diseases of poultry that discernibly affects commercial poultry industry. The mutating viral genome of IBDV accounts for disease outbreaks in fields even after following stringent biosecurity measures and vaccination protocols. The present study is focussed on the characterisation of an IBDV field virus, IBD/CVAS/6, from a vaccinated flock in Kerala, based on the sequence analysis of VP1, VP2 and VP3 genes. Bursa of Fabricius samples collected from a 26 days-old chicken flock from a suspected outbreak in the Thiruvananthapuram district of Kerala formed the subject of the study. Reverse transcriptase-polymerase chain reaction (RT-PCR) targeting VP2 gene confirmed the presence of virus in the sample. The sequence analysis revealed that the deduced amino acid sequence of VP1 gene of IBD/CVAS/6 was 100 per cent homologous with an attenuated very virulent vaccine strain of Israel, mb and the VP2 gene was 100 per cent homologous with mb and Ventri IBDV plus vaccine strain of India. The analysis of VP3 gene also revealed the similarity with vaccine strains except for a single variation S745N in its deduced amino acid sequence. The phylogenetic analysis of IBD/CVAS/6 revealed it’s close relation with mb, Ventri IBDV plus and a very virulent strain of Israel, ks. The characteristic virulent marker amino acid motifs ‘SWSASGS’ and ‘TDN’ were present in the VP2 and VP1 genes, respectively. Hence, the study revealed that the obtained virus has emerged from an attenuated very virulent vaccine strain and hence the present study is a report of involvement of the intermediate plus vaccine strain in field outbreaks in Kerala. The role of S745N in virulence cannot be accounted from the present study, however the involvement of IBD/CVAS/6 in the outbreak might be related to S745N variation or variations in other genes of the virus or due to the inefficiency of the vaccine or vaccination protocol followed, which can be defined only after further studies. The present report is the first characterisation study in Kerala focussing on the analysis of VP1, VP2 and VP3 genes of IBDV." @default.
• W4315564879 created "2023-01-11" @default.
• W4315564879 creator A5007843351 @default.
• W4315564879 creator A5021420322 @default.
• W4315564879 creator A5047689416 @default.
• W4315564879 creator A5059507046 @default.
• W4315564879 creator A5070289860 @default.
• W4315564879 date "2022-01-01" @default.
• W4315564879 modified "2023-09-30" @default.
• W4315564879 title "Sequence analysis of VP1, VP2 and VP3 genes of Infectious Bursal Disease Virus from a field outbreak in Kerala, India" @default.
• W4315564879 doi "https://doi.org/10.51966/jvas.2022.53.4.633-642" @default.
• W4315564879 hasPublicationYear "2022" @default.
• W4315564879 type Work @default.
• W4315564879 citedByCount "0" @default.
• W4315564879 crossrefType "journal-article" @default.
• W4315564879 hasAuthorship W4315564879A5007843351 @default.
• W4315564879 hasAuthorship W4315564879A5021420322 @default.
• W4315564879 hasAuthorship W4315564879A5047689416 @default.
• W4315564879 hasAuthorship W4315564879A5059507046 @default.
• W4315564879 hasAuthorship W4315564879A5070289860 @default.
• W4315564879 hasBestOaLocation W43155648791 @default.
• W4315564879 hasConcept C104317684 @default.
• W4315564879 hasConcept C116675565 @default.
• W4315564879 hasConcept C134215735 @default.
• W4315564879 hasConcept C151730666 @default.
• W4315564879 hasConcept C159047783 @default.
• W4315564879 hasConcept C193252679 @default.
• W4315564879 hasConcept C2522874641 @default.
• W4315564879 hasConcept C2777810641 @default.
• W4315564879 hasConcept C54355233 @default.
• W4315564879 hasConcept C60987743 @default.
• W4315564879 hasConcept C61053724 @default.
• W4315564879 hasConcept C86803240 @default.
• W4315564879 hasConceptScore W4315564879C104317684 @default.
• W4315564879 hasConceptScore W4315564879C116675565 @default.
• W4315564879 hasConceptScore W4315564879C134215735 @default.
• W4315564879 hasConceptScore W4315564879C151730666 @default.
• W4315564879 hasConceptScore W4315564879C159047783 @default.
• W4315564879 hasConceptScore W4315564879C193252679 @default.
• W4315564879 hasConceptScore W4315564879C2522874641 @default.
• W4315564879 hasConceptScore W4315564879C2777810641 @default.
• W4315564879 hasConceptScore W4315564879C54355233 @default.
• W4315564879 hasConceptScore W4315564879C60987743 @default.
• W4315564879 hasConceptScore W4315564879C61053724 @default.
• W4315564879 hasConceptScore W4315564879C86803240 @default.
• W4315564879 hasIssue "4" @default.
• W4315564879 hasLocation W43155648791 @default.
• W4315564879 hasOpenAccess W4315564879 @default.
• W4315564879 hasPrimaryLocation W43155648791 @default.
• W4315564879 hasRelatedWork W1963883483 @default.
• W4315564879 hasRelatedWork W1994878443 @default.
• W4315564879 hasRelatedWork W2033473843 @default.
• W4315564879 hasRelatedWork W2094603343 @default.
• W4315564879 hasRelatedWork W2107230345 @default.
• W4315564879 hasRelatedWork W2745611800 @default.
• W4315564879 hasRelatedWork W2955456233 @default.
• W4315564879 hasRelatedWork W2982791591 @default.
• W4315564879 hasRelatedWork W4288008926 @default.
• W4315564879 hasRelatedWork W79650307 @default.
• W4315564879 hasVolume "53" @default.
• W4315564879 isParatext "false" @default.
• W4315564879 isRetracted "false" @default.
• W4315564879 workType "article" @default.