FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315566314> ?p ?o ?g. }

• W4315566314 endingPage "606" @default.
• W4315566314 startingPage "589" @default.
• W4315566314 abstract "High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE. However, clinical studies comparing daptomycin monotherapy with daptomycin/fosfomycin combinations are unavailable.An observational study of VRE-BSI was performed between 2010-2021 on patients receiving daptomycin monotherapy (≥ 8 mg/kg) or daptomycin combined with intravenous fosfomycin. Patients treated with concomitant β-lactam combinations were excluded. The primary outcome was in-hospital mortality. Outcomes were analyzed using multivariable logistic regression and augmented inverse probability weighting (AIPW) analyses.Among 224 patients, 176 received daptomycin monotherapy, and 48 received fosfomycin combinations. The median daptomycin and fosfomycin doses were 9.8 mg/kg and 12 g/day, respectively. In-hospital mortality was 77.3% and 47.9% in the daptomycin monotherapy and fosfomycin combination groups (P < 0.001), respectively. Multivariable logistic regression analysis predicted lower mortality with fosfomycin combination treatment (adjusted odds ratio, 0.35; 95% confidence interval (CI), 0.17-0.73; P = 0.005). AIPW demonstrated a 17.8% reduced mortality with fosfomycin combinations (95% CI, - 30.6- - 4.9%; P = 0.007). The survival benefit was significant, especially among patients with a lower Pitt bacteremia score or fosfomycin minimum inhibitory concentration (MIC) ≤ 64 mg/l. Fosfomycin combination resulted in higher hypernatremia (10.4% vs. 2.8%, P = 0.04) and hypokalemia (33.3% vs. 15.3%, P = 0.009) compared to daptomycin monotherapy.The combination of high-dose daptomycin with fosfomycin improved the survival rate of patients with VRE-BSI compared to daptomycin alone. The benefit of the combination was most pronounced for VRE with fosfomycin MIC ≤ 64 mg/l and for patients with a low Pitt bacteremia score." @default.
• W4315566314 created "2023-01-11" @default.
• W4315566314 creator A5001492559 @default.
• W4315566314 creator A5011769937 @default.
• W4315566314 creator A5014678817 @default.
• W4315566314 creator A5014753320 @default.
• W4315566314 creator A5037686253 @default.
• W4315566314 creator A5049626738 @default.
• W4315566314 creator A5062263322 @default.
• W4315566314 creator A5091398336 @default.
• W4315566314 date "2023-01-11" @default.
• W4315566314 modified "2023-10-18" @default.
• W4315566314 title "The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study" @default.
• W4315566314 cites W1949620401 @default.
• W4315566314 cites W1971392136 @default.
• W4315566314 cites W2000445173 @default.
• W4315566314 cites W2041441534 @default.
• W4315566314 cites W2096541421 @default.
• W4315566314 cites W2102518716 @default.
• W4315566314 cites W2103599303 @default.
• W4315566314 cites W2115402458 @default.
• W4315566314 cites W2130765730 @default.
• W4315566314 cites W2131455454 @default.
• W4315566314 cites W2132755098 @default.
• W4315566314 cites W2141090247 @default.
• W4315566314 cites W2144387798 @default.
• W4315566314 cites W2157748009 @default.
• W4315566314 cites W2158637043 @default.
• W4315566314 cites W2168543874 @default.
• W4315566314 cites W2336542238 @default.
• W4315566314 cites W2396031127 @default.
• W4315566314 cites W2496099103 @default.
• W4315566314 cites W2501729489 @default.
• W4315566314 cites W2566120898 @default.
• W4315566314 cites W2588897144 @default.
• W4315566314 cites W2759495551 @default.
• W4315566314 cites W2794596746 @default.
• W4315566314 cites W2797066562 @default.
• W4315566314 cites W2806495982 @default.
• W4315566314 cites W2809864058 @default.
• W4315566314 cites W2888467168 @default.
• W4315566314 cites W2891953783 @default.
• W4315566314 cites W3045500321 @default.
• W4315566314 cites W3048457837 @default.
• W4315566314 cites W3134384159 @default.
• W4315566314 cites W3199547112 @default.
• W4315566314 cites W4210706056 @default.
• W4315566314 cites W4211238209 @default.
• W4315566314 cites W4235400911 @default.
• W4315566314 cites W4243220370 @default.
• W4315566314 cites W4282936880 @default.
• W4315566314 doi "https://doi.org/10.1007/s40121-022-00754-1" @default.
• W4315566314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36629997" @default.
• W4315566314 hasPublicationYear "2023" @default.
• W4315566314 type Work @default.
• W4315566314 citedByCount "1" @default.
• W4315566314 countsByYear W43155663142023 @default.
• W4315566314 crossrefType "journal-article" @default.
• W4315566314 hasAuthorship W4315566314A5001492559 @default.
• W4315566314 hasAuthorship W4315566314A5011769937 @default.
• W4315566314 hasAuthorship W4315566314A5014678817 @default.
• W4315566314 hasAuthorship W4315566314A5014753320 @default.
• W4315566314 hasAuthorship W4315566314A5037686253 @default.
• W4315566314 hasAuthorship W4315566314A5049626738 @default.
• W4315566314 hasAuthorship W4315566314A5062263322 @default.
• W4315566314 hasAuthorship W4315566314A5091398336 @default.
• W4315566314 hasBestOaLocation W43155663141 @default.
• W4315566314 hasConcept C126322002 @default.
• W4315566314 hasConcept C141071460 @default.
• W4315566314 hasConcept C156957248 @default.
• W4315566314 hasConcept C2776999253 @default.
• W4315566314 hasConcept C2778651397 @default.
• W4315566314 hasConcept C2778897966 @default.
• W4315566314 hasConcept C2778980435 @default.
• W4315566314 hasConcept C2779443120 @default.
• W4315566314 hasConcept C2779489039 @default.
• W4315566314 hasConcept C501593827 @default.
• W4315566314 hasConcept C523546767 @default.
• W4315566314 hasConcept C54355233 @default.
• W4315566314 hasConcept C71924100 @default.
• W4315566314 hasConcept C86803240 @default.
• W4315566314 hasConcept C89423630 @default.
• W4315566314 hasConcept C90924648 @default.
• W4315566314 hasConceptScore W4315566314C126322002 @default.
• W4315566314 hasConceptScore W4315566314C141071460 @default.
• W4315566314 hasConceptScore W4315566314C156957248 @default.
• W4315566314 hasConceptScore W4315566314C2776999253 @default.
• W4315566314 hasConceptScore W4315566314C2778651397 @default.
• W4315566314 hasConceptScore W4315566314C2778897966 @default.
• W4315566314 hasConceptScore W4315566314C2778980435 @default.
• W4315566314 hasConceptScore W4315566314C2779443120 @default.
• W4315566314 hasConceptScore W4315566314C2779489039 @default.
• W4315566314 hasConceptScore W4315566314C501593827 @default.
• W4315566314 hasConceptScore W4315566314C523546767 @default.
• W4315566314 hasConceptScore W4315566314C54355233 @default.
• W4315566314 hasConceptScore W4315566314C71924100 @default.
• W4315566314 hasConceptScore W4315566314C86803240 @default.
• W4315566314 hasConceptScore W4315566314C89423630 @default.

• next