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- W4315619187 abstract "Background & Aims: The innate-like mucosa-associated invariant T (MAIT) cells are enriched in human liver and have been linked to human hepatocellular carcinoma (HCC). However, their contributions to the progression of HCC are controversial due to the heterogeneity of MAIT cells, and new MAIT cell subsets remain to be explored. Approach & Results: Combining single cell RNA sequencing (scRNA-seq) and flow cytometry analysis, we performed phenotypic and functional studies and found that FOXP3+ CXCR3+ MAIT cells in HCC patients were regulatory MAIT cells (MAITregs) with high immunosuppressive potential. These MAITregs were induced under Treg-inducing condition and predominantly from FOXP3- CXCR3+ MAIT cells, which displayed mild Treg-related features and represented a pre-MAITreg reservoir. Additionally, the induction and function of MAITregs were promoted by β1 adrenergic receptor signaling in pre-MAITregs and MAITregs, respectively. In HCC patients, high proportion of the intratumoral MAITregs inhibited anti-tumor immune responses and was associated with poor clinical outcomes. Conclusions: Together, we reveal an immunosuppressive subset of MAIT cells in HCC patients that contributes to HCC progression, and propose a control through neuro-immune crosstalk. Export" @default.
- W4315619187 created "2023-01-12" @default.
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- W4315619187 date "2023-01-03" @default.
- W4315619187 modified "2023-10-17" @default.
- W4315619187 title "Regulatory mucosa-associated invariant T cells controlled by β1 adrenergic receptor signaling contribute to hepatocellular carcinoma progression" @default.
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- W4315619187 doi "https://doi.org/10.1097/hep.0000000000000014" @default.
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