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• W4315643169 abstract "ABSTRACT Sensors of intracellular double-stranded RNA are central components of metazoan innate antiviral immunity, but such sensors have not been identified in plants. RNA interference (RNAi) constitutes a potent plant antiviral defense mechanism that relies on conversion of viral RNA into small interfering RNAs by two DICER-LIKE (DCL) ribonucleases, DCL4 and DCL2. Here, we show that while plant DCL4 is dedicated to RNAi, cytoplasmic dicing by DCL2 also triggers RNAi-independent defense gene expression via at least two intracellular nucleotide-binding domain/leucine-rich repeat (NLR) immune receptors. Combined DCL4/NLR inactivation abrogates basal resistance to a positive strand RNA virus. Our results redefine the basis of plant antiviral immunity, including autoimmunity as an explanation for DCL2-dependent growth arrest in dcl and RNA decay mutants in several plant species. One sentence summary The plant immune system uses Dicer-like ribonucleases for both antiviral RNA interference and double-stranded RNA sensing." @default.
• W4315643169 created "2023-01-12" @default.
• W4315643169 creator A5041302923 @default.
• W4315643169 creator A5047972688 @default.
• W4315643169 creator A5050995132 @default.
• W4315643169 creator A5053123019 @default.
• W4315643169 creator A5057910690 @default.
• W4315643169 creator A5086543671 @default.
• W4315643169 date "2023-01-11" @default.
• W4315643169 modified "2023-10-01" @default.
• W4315643169 title "Sensing of viral RNA in plants via a DICER-LIKE Ribonuclease" @default.
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