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• W4315643988 endingPage "116930" @default.
• W4315643988 startingPage "116930" @default.
• W4315643988 abstract "Extracellular vesicles (EVs) are membrane vesicles encapsulated by lipid membranes present in most body fluids. These EVs contain abundant biomolecular composition, including proteins, nucleic acids, lipids, metabolites, etc., and thus play an important role in intercellular communication. However, EVs are highly heterogeneous in terms of physical properties and biomolecular composition. Therefore, it is crucially important to study EV on single cell and single particle level for precise analysis and functional evaluation. Microfluidic platforms provide the possibility for single-cell EV analysis by integrating cell manipulation, EV enrichment, sensitive nucleic acid and protein detection together. In this review, we have summarized current status in single-cell EV and single EV particle study by microfluidic platform with advanced detection tools. The importance of single-cell EV on heterogeneity and future development are also discussed and prospected." @default.
• W4315643988 created "2023-01-12" @default.
• W4315643988 creator A5011392084 @default.
• W4315643988 creator A5012094328 @default.
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• W4315643988 creator A5057706703 @default.
• W4315643988 creator A5065492734 @default.
• W4315643988 creator A5084496885 @default.
• W4315643988 creator A5086184972 @default.
• W4315643988 date "2023-02-01" @default.
• W4315643988 modified "2023-10-18" @default.
• W4315643988 title "Single-cell extracellular vesicle analysis by microfluidics and beyond" @default.
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