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• W4315644920 abstract "Abstract The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO 2 +QDs based on the combination of rare earth upconversion (UCNP) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO 2 +QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted in the visible wavelength, specifically identified and highly sensitive. Under the excitation of 980 nm near-infrared light, the UCNP and QDs in the composite produced the maximum efficiency of energy transfer through fluorescence resonance, and the multi-emission light of UCNP synergistically excited the re-emission of QDs, and the energy transfer efficiency is 70.6%. By changing the doping ratio of QDs halogen elements in UCNP@SiO 2 +QDs, it is possible to modulate the precise luminescence of UCNP@SiO 2 +QDs in the entire wavelength range of visible light at different positions. The novel fluorescent probe is obtained using UCNP@SiO 2 +QDs and Black Hole Quencher-1 (BHQ1) quenching groups linked to the two respective sides of MB, selecting as the target of detection the myeloma cancer biomarker miRNA-155, a difficult diagnostic and complex developmental type, and have achieved specific recognition and low concentration of miRNA-155 and a detection limit of 73.5 pM. This fluorescent probe design can provide new ideas for the early diagnosis and treatment of cancer, tumors, and cardiovascular diseases." @default.
• W4315644920 created "2023-01-12" @default.
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• W4315644920 date "2023-01-11" @default.
• W4315644920 modified "2023-10-18" @default.
• W4315644920 title "Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections" @default.
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• W4315644920 doi "https://doi.org/10.21203/rs.3.rs-1972234/v2" @default.
• W4315644920 hasPublicationYear "2023" @default.
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