FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315652102> ?p ?o ?g. }

• W4315652102 endingPage "105099" @default.
• W4315652102 startingPage "105099" @default.
• W4315652102 abstract "Enterotoxigenic Escherichia coli (ETEC) is the main causative pathogen of diarrhea. It causes acute watery diarrhea that leads to rapid dehydration and prostration within hours. ETEC is still an important cause of neonatal and post-weaning diarrhea in pigs. However, the mechanism underlying ETEC-induced diarrhea is not yet clear. In this study, we investigated these mechanisms and found that the mTORC1 pathway plays a role in the host response to ETEC F4 infection. Specifically, we found that ETEC F4 treatment significantly repressed mTORC1 activity as well as cell proliferation, promoted apoptosis and regulated the expression of diarrhea-related genes via the promotion of PKA-mediated phosphorylation of SIN1, which plays a critical role in the assembly of mTORC2. These findings indicate that PKA is a checkpoint for ETEC-induced diarrhea. In terms of potential therapeutic strategies, we found that ZnSO4 dramatically rescued ETEC F4-induced the inhibition of mTORC1 activity and cell viability and the induction of apoptosis and alterations in the expression of diarrhea-related genes. Thus, the present findings demonstrate that ETEC F4 influences mTORC1 activation by inhibiting the assembly of mTORC2 through PKA-mediated phosphorylation of SIN1. Further, supplementation with ZnSO4 is an effective strategy for blocking the effect of ETEC F4 on mTORC1 activation, and it may have potential clinical applications in the treatment of ETEC F4-induced diarrhea." @default.
• W4315652102 created "2023-01-12" @default.
• W4315652102 creator A5000400260 @default.
• W4315652102 creator A5007565819 @default.
• W4315652102 creator A5010738468 @default.
• W4315652102 creator A5018950084 @default.
• W4315652102 creator A5033591103 @default.
• W4315652102 creator A5056997578 @default.
• W4315652102 creator A5071011673 @default.
• W4315652102 creator A5091090760 @default.
• W4315652102 creator A5091589634 @default.
• W4315652102 date "2023-06-01" @default.
• W4315652102 modified "2023-09-24" @default.
• W4315652102 title "Promotion of intestinal epithelial cell apoptosis by enterotoxigenic Escherichia coli via PKA-mediated inhibition of mTORC1 activation" @default.
• W4315652102 cites W1518372713 @default.
• W4315652102 cites W1819784342 @default.
• W4315652102 cites W2001568034 @default.
• W4315652102 cites W2006559495 @default.
• W4315652102 cites W2027995647 @default.
• W4315652102 cites W2037935730 @default.
• W4315652102 cites W2060905299 @default.
• W4315652102 cites W2065887259 @default.
• W4315652102 cites W2066659565 @default.
• W4315652102 cites W2101083009 @default.
• W4315652102 cites W2113486346 @default.
• W4315652102 cites W2116137883 @default.
• W4315652102 cites W2139813645 @default.
• W4315652102 cites W2144059623 @default.
• W4315652102 cites W2152242641 @default.
• W4315652102 cites W2156618766 @default.
• W4315652102 cites W2166106619 @default.
• W4315652102 cites W2473954287 @default.
• W4315652102 cites W2774333756 @default.
• W4315652102 cites W2810823960 @default.
• W4315652102 cites W2898599254 @default.
• W4315652102 cites W2900126649 @default.
• W4315652102 cites W2903397393 @default.
• W4315652102 cites W2937578637 @default.
• W4315652102 cites W2945573573 @default.
• W4315652102 cites W2974639402 @default.
• W4315652102 cites W2980402622 @default.
• W4315652102 cites W2999421965 @default.
• W4315652102 cites W3001558881 @default.
• W4315652102 cites W3103992737 @default.
• W4315652102 cites W3109400450 @default.
• W4315652102 cites W3109580998 @default.
• W4315652102 cites W3132255180 @default.
• W4315652102 cites W3202424071 @default.
• W4315652102 cites W3206476585 @default.
• W4315652102 cites W3206969740 @default.
• W4315652102 cites W4200561035 @default.
• W4315652102 cites W4290018166 @default.
• W4315652102 doi "https://doi.org/10.1016/j.micinf.2023.105099" @default.
• W4315652102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36642296" @default.
• W4315652102 hasPublicationYear "2023" @default.
• W4315652102 type Work @default.
• W4315652102 citedByCount "0" @default.
• W4315652102 crossrefType "journal-article" @default.
• W4315652102 hasAuthorship W4315652102A5000400260 @default.
• W4315652102 hasAuthorship W4315652102A5007565819 @default.
• W4315652102 hasAuthorship W4315652102A5010738468 @default.
• W4315652102 hasAuthorship W4315652102A5018950084 @default.
• W4315652102 hasAuthorship W4315652102A5033591103 @default.
• W4315652102 hasAuthorship W4315652102A5056997578 @default.
• W4315652102 hasAuthorship W4315652102A5071011673 @default.
• W4315652102 hasAuthorship W4315652102A5091090760 @default.
• W4315652102 hasAuthorship W4315652102A5091589634 @default.
• W4315652102 hasBestOaLocation W43156521021 @default.
• W4315652102 hasConcept C104317684 @default.
• W4315652102 hasConcept C126322002 @default.
• W4315652102 hasConcept C190283241 @default.
• W4315652102 hasConcept C2777871010 @default.
• W4315652102 hasConcept C2779802037 @default.
• W4315652102 hasConcept C502942594 @default.
• W4315652102 hasConcept C547475151 @default.
• W4315652102 hasConcept C55493867 @default.
• W4315652102 hasConcept C62478195 @default.
• W4315652102 hasConcept C66999527 @default.
• W4315652102 hasConcept C71924100 @default.
• W4315652102 hasConcept C86554907 @default.
• W4315652102 hasConcept C86803240 @default.
• W4315652102 hasConcept C89423630 @default.
• W4315652102 hasConcept C95444343 @default.
• W4315652102 hasConcept C98490376 @default.
• W4315652102 hasConceptScore W4315652102C104317684 @default.
• W4315652102 hasConceptScore W4315652102C126322002 @default.
• W4315652102 hasConceptScore W4315652102C190283241 @default.
• W4315652102 hasConceptScore W4315652102C2777871010 @default.
• W4315652102 hasConceptScore W4315652102C2779802037 @default.
• W4315652102 hasConceptScore W4315652102C502942594 @default.
• W4315652102 hasConceptScore W4315652102C547475151 @default.
• W4315652102 hasConceptScore W4315652102C55493867 @default.
• W4315652102 hasConceptScore W4315652102C62478195 @default.
• W4315652102 hasConceptScore W4315652102C66999527 @default.
• W4315652102 hasConceptScore W4315652102C71924100 @default.
• W4315652102 hasConceptScore W4315652102C86554907 @default.
• W4315652102 hasConceptScore W4315652102C86803240 @default.
• W4315652102 hasConceptScore W4315652102C89423630 @default.

• next