Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315698720> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4315698720 abstract "Immunomodulators play an important role in combination chemotherapy of multiple myeloma. Besides, it has been reported that leukotriene-D4 receptors play an important role in carcinogenesis. The current study was carried out to assess the possible antitumor effects of montelukast (both an immunomodulator and a CysLT1R antagonist) both in single and in combination with carfilzomib in multiple myeloma cells and the potential mechanisms. We performed our experiment using cell apoptosis assay, cell cycle assay, western blot analysis, mitochondrial transmembrane potential, and chemical proteomics based on protein activity. The results showed that montelukast inhibits cell proliferation and leads to cell apoptosis in multiple myeloma cell lines. Then we performed combination of montelukast and carfilzomib on multiple myeloma cells to explore whether they are synergistic. We demonstrated that the combination treatment leads to stronger effect of cell apoptosis. Furthermore, we demonstrated the combination effect is performed independent of the leukotriene-D4 receptors inhibition. Given that protesome inhibitor leads to accumulation of ubiquitin by inhibiting the degradation of these proteins, we tested ubiquitin levels of different groups. We found that montelukast induces ubiquitin accumulation by inhibiting Ubiquitin-Specific Protease UCHL1. All of these lead to the activity of indoplasmic reticulum stress and therefore result in cell apoptosis. This brings us a new idea in the treatment of multiple myeloma. Since montelukast is cheap and widely used in clinic, if it is proved to be effective in the treatment of multiple myeloma, it will greatly reduce the economic pressure of patients and bring new hope to patients." @default.
- W4315698720 created "2023-01-12" @default.
- W4315698720 creator A5003799076 @default.
- W4315698720 creator A5012113615 @default.
- W4315698720 creator A5019040252 @default.
- W4315698720 creator A5019719608 @default.
- W4315698720 creator A5022416507 @default.
- W4315698720 creator A5027925432 @default.
- W4315698720 creator A5048065642 @default.
- W4315698720 creator A5050141240 @default.
- W4315698720 creator A5050712578 @default.
- W4315698720 creator A5051765654 @default.
- W4315698720 creator A5054920241 @default.
- W4315698720 creator A5068047224 @default.
- W4315698720 date "2022-04-01" @default.
- W4315698720 modified "2023-10-17" @default.
- W4315698720 title "Montelukast Performs Synergistic Effect with Carfilzomib in Multiple Myeloma by Inhibiting the Deubiquitinase UCHL1" @default.
- W4315698720 doi "https://doi.org/10.26420/austinjcancerclinres.2022.1101" @default.
- W4315698720 hasPublicationYear "2022" @default.
- W4315698720 type Work @default.
- W4315698720 citedByCount "0" @default.
- W4315698720 crossrefType "journal-article" @default.
- W4315698720 hasAuthorship W4315698720A5003799076 @default.
- W4315698720 hasAuthorship W4315698720A5012113615 @default.
- W4315698720 hasAuthorship W4315698720A5019040252 @default.
- W4315698720 hasAuthorship W4315698720A5019719608 @default.
- W4315698720 hasAuthorship W4315698720A5022416507 @default.
- W4315698720 hasAuthorship W4315698720A5027925432 @default.
- W4315698720 hasAuthorship W4315698720A5048065642 @default.
- W4315698720 hasAuthorship W4315698720A5050141240 @default.
- W4315698720 hasAuthorship W4315698720A5050712578 @default.
- W4315698720 hasAuthorship W4315698720A5051765654 @default.
- W4315698720 hasAuthorship W4315698720A5054920241 @default.
- W4315698720 hasAuthorship W4315698720A5068047224 @default.
- W4315698720 hasBestOaLocation W43156987201 @default.
- W4315698720 hasConcept C104317684 @default.
- W4315698720 hasConcept C185592680 @default.
- W4315698720 hasConcept C190283241 @default.
- W4315698720 hasConcept C203014093 @default.
- W4315698720 hasConcept C25602115 @default.
- W4315698720 hasConcept C2776042228 @default.
- W4315698720 hasConcept C2776322731 @default.
- W4315698720 hasConcept C2776364478 @default.
- W4315698720 hasConcept C2778367456 @default.
- W4315698720 hasConcept C2780108899 @default.
- W4315698720 hasConcept C502942594 @default.
- W4315698720 hasConcept C55493867 @default.
- W4315698720 hasConcept C62112901 @default.
- W4315698720 hasConcept C86803240 @default.
- W4315698720 hasConcept C95444343 @default.
- W4315698720 hasConcept C98274493 @default.
- W4315698720 hasConceptScore W4315698720C104317684 @default.
- W4315698720 hasConceptScore W4315698720C185592680 @default.
- W4315698720 hasConceptScore W4315698720C190283241 @default.
- W4315698720 hasConceptScore W4315698720C203014093 @default.
- W4315698720 hasConceptScore W4315698720C25602115 @default.
- W4315698720 hasConceptScore W4315698720C2776042228 @default.
- W4315698720 hasConceptScore W4315698720C2776322731 @default.
- W4315698720 hasConceptScore W4315698720C2776364478 @default.
- W4315698720 hasConceptScore W4315698720C2778367456 @default.
- W4315698720 hasConceptScore W4315698720C2780108899 @default.
- W4315698720 hasConceptScore W4315698720C502942594 @default.
- W4315698720 hasConceptScore W4315698720C55493867 @default.
- W4315698720 hasConceptScore W4315698720C62112901 @default.
- W4315698720 hasConceptScore W4315698720C86803240 @default.
- W4315698720 hasConceptScore W4315698720C95444343 @default.
- W4315698720 hasConceptScore W4315698720C98274493 @default.
- W4315698720 hasIssue "1" @default.
- W4315698720 hasLocation W43156987201 @default.
- W4315698720 hasOpenAccess W4315698720 @default.
- W4315698720 hasPrimaryLocation W43156987201 @default.
- W4315698720 hasRelatedWork W2063424779 @default.
- W4315698720 hasRelatedWork W2412699480 @default.
- W4315698720 hasRelatedWork W2417132786 @default.
- W4315698720 hasRelatedWork W2521212135 @default.
- W4315698720 hasRelatedWork W2737046165 @default.
- W4315698720 hasRelatedWork W2887253292 @default.
- W4315698720 hasRelatedWork W2949071566 @default.
- W4315698720 hasRelatedWork W3138675442 @default.
- W4315698720 hasRelatedWork W4250719716 @default.
- W4315698720 hasRelatedWork W4315698720 @default.
- W4315698720 hasVolume "9" @default.
- W4315698720 isParatext "false" @default.
- W4315698720 isRetracted "false" @default.
- W4315698720 workType "article" @default.