FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315701228> ?p ?o ?g. }

• W4315701228 endingPage "17" @default.
• W4315701228 startingPage "7" @default.
• W4315701228 abstract "Repeated transfusions in thalassemia patients can cause several complications, including alloimmunization and autoimmunization.This study compares the immune response of T follicular helper (Tfh) lymphocytes expressing T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory domains (TIGIT), programmed cell death-1 (PD-1), and interleukin-21 (IL-21) between patients with allo-auto positive and negative thalassemia before and after hemin administration.This study used a quasi-experimental pre- and post-test design and was performed between April and November 2021 at the Dr. Soetomo General Academic Hospital in Surabaya, Indonesia. It enrolled 29 patients with allo-auto positive thalassemia and 28 with allo-auto negative, and 9 mL of whole blood (WB) was drawn from each patient. Hemin solution (20 µM) was added to 5 mL of WB, incubated for two hours, processed into peripheral blood mononuclear cells (PBMCs) in RPMI media, and cultured with 5% CO2 for three days. The 4 mL WB sample was also processed into PBMCs. PBMC cells cultured and without cultured were examined by flow cytometry using a BD FACSCalibur after surface and intracellular staining. Differences in Tfh cells expressing TIGIT, PD-1, and IL-21 between thalassemia groups before and after hemin administration were compared using independent t-tests or Mann-Whitney U-tests (p < 0.05).Tfh cell expression did not differ between groups before hemin administration and increased after hemin administration. The increase in Tfh cell expression was higher in the allo-auto positive group. TIGIT and PD-1 expression in Tfh cells did not differ between groups, but TIGIT decreased after hemin administration in contrast to PD-1 result. IL-21 expression in Tfh cells did not differ between groups and did not change after hemin administration.Hemin affected the expression of Tfh cells in both group thalassemia, but there was no difference of Tfh cell expression between the groups." @default.
• W4315701228 created "2023-01-12" @default.
• W4315701228 creator A5043235316 @default.
• W4315701228 creator A5043447280 @default.
• W4315701228 creator A5075645371 @default.
• W4315701228 date "2023-01-01" @default.
• W4315701228 modified "2023-09-27" @default.
• W4315701228 title "Role of Hemin in the Immune Response of T Follicular Helper Lymphocytes Expressing T-Cell Immunoreceptor with Immunoglobulin and Immunoreceptor Tyrosine-Based Inhibitory Domains, Programmed Cell Death-1, and Interleukin-21 in Allo-Auto Positive and Negative Thalassemia" @default.
• W4315701228 cites W1601004541 @default.
• W4315701228 cites W1628565269 @default.
• W4315701228 cites W1909852326 @default.
• W4315701228 cites W1916428710 @default.
• W4315701228 cites W1946284923 @default.
• W4315701228 cites W1990348073 @default.
• W4315701228 cites W1991860621 @default.
• W4315701228 cites W1998403286 @default.
• W4315701228 cites W2001775594 @default.
• W4315701228 cites W2005904261 @default.
• W4315701228 cites W2051058933 @default.
• W4315701228 cites W2055923182 @default.
• W4315701228 cites W2112154893 @default.
• W4315701228 cites W2133790929 @default.
• W4315701228 cites W2142169541 @default.
• W4315701228 cites W2206790822 @default.
• W4315701228 cites W2213332728 @default.
• W4315701228 cites W2338546365 @default.
• W4315701228 cites W2556313489 @default.
• W4315701228 cites W2560827811 @default.
• W4315701228 cites W2573824940 @default.
• W4315701228 cites W2580686727 @default.
• W4315701228 cites W2592339311 @default.
• W4315701228 cites W2593608003 @default.
• W4315701228 cites W2762907911 @default.
• W4315701228 cites W2767498689 @default.
• W4315701228 cites W2781387181 @default.
• W4315701228 cites W2781905271 @default.
• W4315701228 cites W2788282141 @default.
• W4315701228 cites W2788601498 @default.
• W4315701228 cites W2789341089 @default.
• W4315701228 cites W285286770 @default.
• W4315701228 cites W2886058877 @default.
• W4315701228 cites W2910869058 @default.
• W4315701228 cites W2913970879 @default.
• W4315701228 cites W2955330067 @default.
• W4315701228 cites W2955801380 @default.
• W4315701228 cites W2995810853 @default.
• W4315701228 cites W2997863542 @default.
• W4315701228 cites W3085648635 @default.
• W4315701228 cites W3089041431 @default.
• W4315701228 cites W3157714754 @default.
• W4315701228 cites W3193513961 @default.
• W4315701228 doi "https://doi.org/10.2147/jbm.s393134" @default.
• W4315701228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36660451" @default.
• W4315701228 hasPublicationYear "2023" @default.
• W4315701228 type Work @default.
• W4315701228 citedByCount "0" @default.
• W4315701228 crossrefType "journal-article" @default.
• W4315701228 hasAuthorship W4315701228A5043235316 @default.
• W4315701228 hasAuthorship W4315701228A5043447280 @default.
• W4315701228 hasAuthorship W4315701228A5075645371 @default.
• W4315701228 hasBestOaLocation W43157012281 @default.
• W4315701228 hasConcept C137061746 @default.
• W4315701228 hasConcept C159654299 @default.
• W4315701228 hasConcept C181199279 @default.
• W4315701228 hasConcept C202751555 @default.
• W4315701228 hasConcept C203014093 @default.
• W4315701228 hasConcept C2776090121 @default.
• W4315701228 hasConcept C2776217839 @default.
• W4315701228 hasConcept C2777723881 @default.
• W4315701228 hasConcept C2779118045 @default.
• W4315701228 hasConcept C553184892 @default.
• W4315701228 hasConcept C55493867 @default.
• W4315701228 hasConcept C71924100 @default.
• W4315701228 hasConcept C86803240 @default.
• W4315701228 hasConcept C8891405 @default.
• W4315701228 hasConceptScore W4315701228C137061746 @default.
• W4315701228 hasConceptScore W4315701228C159654299 @default.
• W4315701228 hasConceptScore W4315701228C181199279 @default.
• W4315701228 hasConceptScore W4315701228C202751555 @default.
• W4315701228 hasConceptScore W4315701228C203014093 @default.
• W4315701228 hasConceptScore W4315701228C2776090121 @default.
• W4315701228 hasConceptScore W4315701228C2776217839 @default.
• W4315701228 hasConceptScore W4315701228C2777723881 @default.
• W4315701228 hasConceptScore W4315701228C2779118045 @default.
• W4315701228 hasConceptScore W4315701228C553184892 @default.
• W4315701228 hasConceptScore W4315701228C55493867 @default.
• W4315701228 hasConceptScore W4315701228C71924100 @default.
• W4315701228 hasConceptScore W4315701228C86803240 @default.
• W4315701228 hasConceptScore W4315701228C8891405 @default.
• W4315701228 hasLocation W43157012281 @default.
• W4315701228 hasLocation W43157012282 @default.
• W4315701228 hasLocation W43157012283 @default.
• W4315701228 hasOpenAccess W4315701228 @default.
• W4315701228 hasPrimaryLocation W43157012281 @default.
• W4315701228 hasRelatedWork W2022017871 @default.
• W4315701228 hasRelatedWork W2043312464 @default.
• W4315701228 hasRelatedWork W2092945558 @default.
• W4315701228 hasRelatedWork W3023412722 @default.

• next