Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315702892> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4315702892 abstract "Abstract Background: Obstructive sleep apnoea (OSA) has a high prevalence in patients with Alzheimer's disease (AD). Both conditions have been shown to be associated with lipid dysregulation. However, the relationship between OSA severity and alterations in lipid metabolism in the brains of patients with AD has yet to be fully elucidated. In this context, we examined the cerebrospinal fluid (CSF) lipidome of patients with suspected OSA to identify potential diagnostic biomarkers and to provide insights into the pathophysiological mechanisms underlying the effect of OSA on AD. Methods: The study included 91 consecutive AD patients who underwent overnight polysomnography (PSG) to diagnose severe OSA (apnoea-hypopnea index ≥30/h). The next morning, CSF samples were collected and analysed by liquid chromatography coupled to mass spectrometry in an LC-ESI-QTOF-MS/MS platform. Results: The CSF levels of 11 lipid species were significantly different between AD patients with and without severe OSA. Five lipids were significantly correlated with specific PSG measures of OSA severity related to sleep fragmentation and hypoxemia. Our analyses revealed a 4-lipid signature (including oxidized ceramide OxCer(40:6)) and three unknown lipids) that provided an accuracy of 0.80 (95% CI: 0.71–0.89) in the detection of severe OSA. These lipids increased the discriminative power of the STOP-Bang questionnaire in terms of the area under the curve (AUC) from 0.61 (0.50-0.74) to 0.85 (0.71-0.93). Conclusions: Our results reveal a CSF lipidomic fingerprint that allows the identification of AD patients with severe OSA. Our findings suggest that an increase in central nervous system lipoxidation may be the principal mechanism underlying the association between OSA and AD." @default.
- W4315702892 created "2023-01-12" @default.
- W4315702892 creator A5010084022 @default.
- W4315702892 creator A5021032386 @default.
- W4315702892 creator A5022711756 @default.
- W4315702892 creator A5033484900 @default.
- W4315702892 creator A5045533547 @default.
- W4315702892 creator A5046990649 @default.
- W4315702892 creator A5063507682 @default.
- W4315702892 creator A5071449113 @default.
- W4315702892 creator A5080088329 @default.
- W4315702892 creator A5084391674 @default.
- W4315702892 creator A5090305856 @default.
- W4315702892 creator A5091181594 @default.
- W4315702892 date "2023-01-12" @default.
- W4315702892 modified "2023-10-18" @default.
- W4315702892 title "Cerebrospinal Fluid Lipidomic Fingerprint of Obstructive Sleep Apnoea in Alzheimer’s Disease" @default.
- W4315702892 cites W2996417078 @default.
- W4315702892 cites W3034639723 @default.
- W4315702892 cites W4235875658 @default.
- W4315702892 cites W4304808129 @default.
- W4315702892 doi "https://doi.org/10.21203/rs.3.rs-2459571/v1" @default.
- W4315702892 hasPublicationYear "2023" @default.
- W4315702892 type Work @default.
- W4315702892 citedByCount "0" @default.
- W4315702892 crossrefType "posted-content" @default.
- W4315702892 hasAuthorship W4315702892A5010084022 @default.
- W4315702892 hasAuthorship W4315702892A5021032386 @default.
- W4315702892 hasAuthorship W4315702892A5022711756 @default.
- W4315702892 hasAuthorship W4315702892A5033484900 @default.
- W4315702892 hasAuthorship W4315702892A5045533547 @default.
- W4315702892 hasAuthorship W4315702892A5046990649 @default.
- W4315702892 hasAuthorship W4315702892A5063507682 @default.
- W4315702892 hasAuthorship W4315702892A5071449113 @default.
- W4315702892 hasAuthorship W4315702892A5080088329 @default.
- W4315702892 hasAuthorship W4315702892A5084391674 @default.
- W4315702892 hasAuthorship W4315702892A5090305856 @default.
- W4315702892 hasAuthorship W4315702892A5091181594 @default.
- W4315702892 hasBestOaLocation W43157028921 @default.
- W4315702892 hasConcept C126322002 @default.
- W4315702892 hasConcept C151730666 @default.
- W4315702892 hasConcept C2776779939 @default.
- W4315702892 hasConcept C2778205975 @default.
- W4315702892 hasConcept C2779343474 @default.
- W4315702892 hasConcept C2779651940 @default.
- W4315702892 hasConcept C2780241833 @default.
- W4315702892 hasConcept C2781326671 @default.
- W4315702892 hasConcept C4733338 @default.
- W4315702892 hasConcept C58017582 @default.
- W4315702892 hasConcept C60644358 @default.
- W4315702892 hasConcept C71924100 @default.
- W4315702892 hasConcept C86803240 @default.
- W4315702892 hasConcept C90924648 @default.
- W4315702892 hasConceptScore W4315702892C126322002 @default.
- W4315702892 hasConceptScore W4315702892C151730666 @default.
- W4315702892 hasConceptScore W4315702892C2776779939 @default.
- W4315702892 hasConceptScore W4315702892C2778205975 @default.
- W4315702892 hasConceptScore W4315702892C2779343474 @default.
- W4315702892 hasConceptScore W4315702892C2779651940 @default.
- W4315702892 hasConceptScore W4315702892C2780241833 @default.
- W4315702892 hasConceptScore W4315702892C2781326671 @default.
- W4315702892 hasConceptScore W4315702892C4733338 @default.
- W4315702892 hasConceptScore W4315702892C58017582 @default.
- W4315702892 hasConceptScore W4315702892C60644358 @default.
- W4315702892 hasConceptScore W4315702892C71924100 @default.
- W4315702892 hasConceptScore W4315702892C86803240 @default.
- W4315702892 hasConceptScore W4315702892C90924648 @default.
- W4315702892 hasLocation W43157028921 @default.
- W4315702892 hasOpenAccess W4315702892 @default.
- W4315702892 hasPrimaryLocation W43157028921 @default.
- W4315702892 hasRelatedWork W2732317838 @default.
- W4315702892 hasRelatedWork W2768723747 @default.
- W4315702892 hasRelatedWork W2982213622 @default.
- W4315702892 hasRelatedWork W2986402841 @default.
- W4315702892 hasRelatedWork W3097007476 @default.
- W4315702892 hasRelatedWork W3158510086 @default.
- W4315702892 hasRelatedWork W3216588482 @default.
- W4315702892 hasRelatedWork W4308435312 @default.
- W4315702892 hasRelatedWork W4315702892 @default.
- W4315702892 hasRelatedWork W4317479263 @default.
- W4315702892 isParatext "false" @default.
- W4315702892 isRetracted "false" @default.
- W4315702892 workType "article" @default.