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• W4315702941 abstract "American cutaneous leishmaniasis (ACL) is one of the most complex parasitic diseases from a clinical-immunopathological point of view due to the great heterogeneity of Leishmania species responsible for the disease. Currently, fifteen Leishmania species of the subgenera Leishmania, Viannia and Mundinia may give rise to ACL in Latin America. In Brazil, seven species are associated to the disease, but L. (V.) braziliensis and L. (L.) amazonensis stand out for producing the broadest clinical-immunopathological spectrum: localized cutaneous leishmaniasis [LCL: DTH+/++], borderline disseminated cutaneous leishmaniasis [BDCL: DTH+/−], mucocutaneous or mucosal leishmaniasis [MCL/ML: DTH++++], and anergic diffuse cutaneous leishmaniasis [ADCL: DTH−]. Although human genetic profile plays important factor in the immunopathogenesis of ACL, it deserves to be highlighted the crucial role of species-specific antigens of L. (V.) braziliensis and L. (L.) amazonensis [lipophosphoglycans, phosphatidylserine, proteophosphoglycans, glycoprotein-63 and CD200 – a macrophage activation inhibitor molecule] in the modulation of T-cell immune response (CD4+/CD8+) that will define the infection evolution." @default.
• W4315702941 created "2023-01-12" @default.
• W4315702941 creator A5002011943 @default.
• W4315702941 creator A5007847907 @default.
• W4315702941 creator A5034289660 @default.
• W4315702941 creator A5054537404 @default.
• W4315702941 creator A5060616667 @default.
• W4315702941 creator A5063153842 @default.
• W4315702941 creator A5066684499 @default.
• W4315702941 creator A5068508748 @default.
• W4315702941 creator A5080686558 @default.
• W4315702941 creator A5090966312 @default.
• W4315702941 date "2023-01-05" @default.
• W4315702941 modified "2023-10-18" @default.
• W4315702941 title "From Biology to Disease: Importance of Species-Specific <i>Leishmania</i> Antigens from the Subgenera <i>Viannia</i> (<i>L. braziliensis</i>) and <i>Leishmania</i> (<i>L. amazonensis</i>) in the Pathogenesis of American Cutaneous Leishmaniasis" @default.
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