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- W4315703367 abstract "Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with the system at the level of renin, angiotensin-converting enzyme or the angiotensin II receptor. Yet, in particular for the treatment of hypertension, the number of patients with uncontrolled hypertension continues to rise, either due to patient non-compliance, or because of the significant renin rises that may, at least partially, overcome the effect of RAS blockade (RAS escape). New approaches to target the RAS are either direct antisense oligonucleotides (ASO) that inhibit angiotensinogen RNA translation, or small interfering ribonucleic acids (siRNA) that function via the RNA interference pathway. Since all angiotensins stem from angiotensinogen, lowering angiotensinogen has the potential to circumvent the RAS escape phenomenon. Moreover, ASO and siRNA require injections only every few weeks to months, which might reduce non-compliance. Of course, angiotensinogen suppression also poses a threat in situations where the RAS is acutely needed, for instance in women becoming pregnant during treatment, or in cases of emergency, when severe hypotension occurs. This presentation discusses all preclinical data on angiotensinogen suppression, as well as the limited clinical data that are currently available. It concludes that it is an exciting new tool to target the RAS with high specificity and a low side effect profile. Its long-term action might revolutionize pharmacotherapy, as it could overcome compliance problems. Preclinical and clinical programs are now carefully investigating its efficacy and safety profile, allowing an optimal introduction as a novel drug to treat cardiovascular and renal diseases in due time." @default.
- W4315703367 created "2023-01-12" @default.
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- W4315703367 date "2023-01-01" @default.
- W4315703367 modified "2023-10-02" @default.
- W4315703367 title "S-19-4: ANGIOTENSINOGEN SIRNA FOR HYPERTENSIVE PATIENTS" @default.
- W4315703367 doi "https://doi.org/10.1097/01.hjh.0000913188.72369.f3" @default.
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