Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315703379> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4315703379 endingPage "e328" @default.
- W4315703379 startingPage "e328" @default.
- W4315703379 abstract "Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in high-risk patients. However, the influence of circulating PCSK9 concentration on atherosclerotic plaque formation in the younger, healthy population is not fully elucidated. We assessed the relationship between serum PCSK9 concentration and coronary artery calcium (CAC) prevalence in the general population with no history of cardiovascular disease in different age group.Methods: Community-dwelling Japanese men (n = 622) aged 46–82 years, without a history of cardiovascular disease or lipid-lowering medications, were included. Serum PCSK9 concentration and CAC score were measured using the Agatston method, and CAC was defined as an Agatston score of > 10. Multivariable Poisson regression with robust error variance were used to estimate the relative risk (RR) and 95% confidence interval (CI) per 1 SD of the serum PCSK9 concentration for the presence of CAC. We conducted further analysis stratified by age (< 60, 60–69, and 70 ≦ years). Results: The average age, LDL-C, and median serum PCSK9 concentration were 68 years, 122 mg/dL, and 240 ng/mL, respectively. After multivariable adjustment for traditional cardiovascular risk factors, no significant association was observed between serum PCSK9 concentration and CAC prevalence (adjusted relative risk [aRR] 1.05, 95% CI 0.97–1.13). With age stratification, serum PCSK9 concentration was significantly associated with CAC prevalence in men aged < 60 years (aRR 1.38, 95% CI 1.01–1.88), but not in men aged 60–69 years (aRR 0.96, 95% CI 0.85–1.10) or ≧ 70 years (aRR 1.08, 95% CI 0.99–1.19). Conclusions: A higher serum PCSK9 concentration was associated with a higher CAC prevalence in men aged < 60 years, which was independent of traditional cardiovascular risk factors. The results of our study suggest that serum PCSK9 concentration might be associated with earlier-stage atherosclerosis." @default.
- W4315703379 created "2023-01-12" @default.
- W4315703379 creator A5005913422 @default.
- W4315703379 creator A5006558823 @default.
- W4315703379 creator A5008587853 @default.
- W4315703379 creator A5010599130 @default.
- W4315703379 creator A5017952469 @default.
- W4315703379 creator A5027888574 @default.
- W4315703379 creator A5029224157 @default.
- W4315703379 creator A5035012330 @default.
- W4315703379 creator A5051497973 @default.
- W4315703379 creator A5054947155 @default.
- W4315703379 creator A5065111589 @default.
- W4315703379 creator A5079494440 @default.
- W4315703379 date "2023-01-01" @default.
- W4315703379 modified "2023-10-02" @default.
- W4315703379 title "PS-BPP01-4: THE RELATIONSHIP BETWEEN SERUM PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 CONCENTRATION AND THE PREVALENCE OF CORONARY ARTERY CALCIUM" @default.
- W4315703379 doi "https://doi.org/10.1097/01.hjh.0000916088.71668.b1" @default.
- W4315703379 hasPublicationYear "2023" @default.
- W4315703379 type Work @default.
- W4315703379 citedByCount "0" @default.
- W4315703379 crossrefType "journal-article" @default.
- W4315703379 hasAuthorship W4315703379A5005913422 @default.
- W4315703379 hasAuthorship W4315703379A5006558823 @default.
- W4315703379 hasAuthorship W4315703379A5008587853 @default.
- W4315703379 hasAuthorship W4315703379A5010599130 @default.
- W4315703379 hasAuthorship W4315703379A5017952469 @default.
- W4315703379 hasAuthorship W4315703379A5027888574 @default.
- W4315703379 hasAuthorship W4315703379A5029224157 @default.
- W4315703379 hasAuthorship W4315703379A5035012330 @default.
- W4315703379 hasAuthorship W4315703379A5051497973 @default.
- W4315703379 hasAuthorship W4315703379A5054947155 @default.
- W4315703379 hasAuthorship W4315703379A5065111589 @default.
- W4315703379 hasAuthorship W4315703379A5079494440 @default.
- W4315703379 hasBestOaLocation W43157033791 @default.
- W4315703379 hasConcept C126322002 @default.
- W4315703379 hasConcept C134018914 @default.
- W4315703379 hasConcept C164705383 @default.
- W4315703379 hasConcept C2778163477 @default.
- W4315703379 hasConcept C2778213512 @default.
- W4315703379 hasConcept C2778849439 @default.
- W4315703379 hasConcept C2780072125 @default.
- W4315703379 hasConcept C2780609585 @default.
- W4315703379 hasConcept C2780948078 @default.
- W4315703379 hasConcept C2908647359 @default.
- W4315703379 hasConcept C2994533308 @default.
- W4315703379 hasConcept C43554185 @default.
- W4315703379 hasConcept C44249647 @default.
- W4315703379 hasConcept C71924100 @default.
- W4315703379 hasConcept C73269764 @default.
- W4315703379 hasConcept C82789193 @default.
- W4315703379 hasConcept C90924648 @default.
- W4315703379 hasConcept C99454951 @default.
- W4315703379 hasConceptScore W4315703379C126322002 @default.
- W4315703379 hasConceptScore W4315703379C134018914 @default.
- W4315703379 hasConceptScore W4315703379C164705383 @default.
- W4315703379 hasConceptScore W4315703379C2778163477 @default.
- W4315703379 hasConceptScore W4315703379C2778213512 @default.
- W4315703379 hasConceptScore W4315703379C2778849439 @default.
- W4315703379 hasConceptScore W4315703379C2780072125 @default.
- W4315703379 hasConceptScore W4315703379C2780609585 @default.
- W4315703379 hasConceptScore W4315703379C2780948078 @default.
- W4315703379 hasConceptScore W4315703379C2908647359 @default.
- W4315703379 hasConceptScore W4315703379C2994533308 @default.
- W4315703379 hasConceptScore W4315703379C43554185 @default.
- W4315703379 hasConceptScore W4315703379C44249647 @default.
- W4315703379 hasConceptScore W4315703379C71924100 @default.
- W4315703379 hasConceptScore W4315703379C73269764 @default.
- W4315703379 hasConceptScore W4315703379C82789193 @default.
- W4315703379 hasConceptScore W4315703379C90924648 @default.
- W4315703379 hasConceptScore W4315703379C99454951 @default.
- W4315703379 hasIssue "Suppl 1" @default.
- W4315703379 hasLocation W43157033791 @default.
- W4315703379 hasLocation W43157033792 @default.
- W4315703379 hasOpenAccess W4315703379 @default.
- W4315703379 hasPrimaryLocation W43157033791 @default.
- W4315703379 hasRelatedWork W2035331946 @default.
- W4315703379 hasRelatedWork W2055270596 @default.
- W4315703379 hasRelatedWork W2273429777 @default.
- W4315703379 hasRelatedWork W2555963695 @default.
- W4315703379 hasRelatedWork W2743003440 @default.
- W4315703379 hasRelatedWork W2893837634 @default.
- W4315703379 hasRelatedWork W3012051999 @default.
- W4315703379 hasRelatedWork W3088002432 @default.
- W4315703379 hasRelatedWork W3181456139 @default.
- W4315703379 hasRelatedWork W4293584956 @default.
- W4315703379 hasVolume "41" @default.
- W4315703379 isParatext "false" @default.
- W4315703379 isRetracted "false" @default.
- W4315703379 workType "article" @default.