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- W4315705022 abstract "Objective: Various endocrinometabolic diseases inclusively polycystic ovarian syndrome (PCOS), has been linked with increased risk of renal dysfunction with attendant cardiovascular disease (CVD) in women of reproductive age. Short chain fatty acids (SCFAs) especially acetate have been suggested as an immunometabolic modulator. However, the impact of SCFAs, particularly acetate on renal disorder in PCOS individuals is unknown. The present study therefore hypothesized that acetate would circumvent renal dysfunction in a rat model of PCOS. Design and Methods: Eight-week-old female Wistar rats were randomly distributed in four groups (n = 6), which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus acetate respectively. The administrations were done once daily by oral gavage for a duration of 21 days. Results: Animals with PCOS displayed insulin resistance, lipid dysmetabolism, hyperandrogenism, hyperleptinemia and hypoadiponectinemia. Besides, the result also showed increased renal malondialdehyde, lactate production, inflammatory mediators, urea and creatinine levels. Immunohistochemical analysis also demonstrated severe expression of apoptosis and inflammation with BAX/NLRP3 antibodies. However, supplementation with acetate significantly attenuated these anomalies. Conclusion: The present results collectively suggest that acetate reverses renal dysfunction in experimentally induced PCOS animals by attenuating androgen excess, apoptosis, oxidative stress and NF-kB/NLRP3 immunoreactivity." @default.
- W4315705022 created "2023-01-12" @default.
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- W4315705022 date "2023-01-01" @default.
- W4315705022 modified "2023-10-02" @default.
- W4315705022 title "PS-B05-5: PROTECTIVE ROLE OF ACETATE AGAINST RENAL DYSFUNCTION IN EXPERIMENTAL MODEL OF POLYCYSTIC OVARIAN SYNDROME" @default.
- W4315705022 doi "https://doi.org/10.1097/01.hjh.0000916496.85717.00" @default.
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