Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315705320> ?p ?o ?g. }
- W4315705320 endingPage "238.e14" @default.
- W4315705320 startingPage "219" @default.
- W4315705320 abstract "Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for modeling neurological diseases. However, iPSC models are fraught with technical limitations including abnormal aggregation and inefficient maturation of differentiated neurons. These problems are in part due to the absence of synergistic cues of the native extracellular matrix (ECM). We report on the use of three artificial ECMs based on peptide amphiphile (PA) supramolecular nanofibers. All nanofibers display the laminin-derived IKVAV signal on their surface but differ in the nature of their non-bioactive domains. We find that nanofibers with greater intensity of internal supramolecular motion have enhanced bioactivity toward hiPSC-derived motor and cortical neurons. Proteomic, biochemical, and functional assays reveal that highly mobile PA scaffolds caused enhanced β1-integrin pathway activation, reduced aggregation, increased arborization, and matured electrophysiological activity of neurons. Our work highlights the importance of designing biomimetic ECMs to study the development, function, and dysfunction of human neurons." @default.
- W4315705320 created "2023-01-12" @default.
- W4315705320 creator A5000682543 @default.
- W4315705320 creator A5007966057 @default.
- W4315705320 creator A5009019341 @default.
- W4315705320 creator A5009547150 @default.
- W4315705320 creator A5022237626 @default.
- W4315705320 creator A5026316779 @default.
- W4315705320 creator A5036685990 @default.
- W4315705320 creator A5048437678 @default.
- W4315705320 creator A5057679210 @default.
- W4315705320 creator A5067408473 @default.
- W4315705320 creator A5073809009 @default.
- W4315705320 creator A5075185586 @default.
- W4315705320 creator A5076417343 @default.
- W4315705320 creator A5077661342 @default.
- W4315705320 creator A5079222349 @default.
- W4315705320 creator A5083011256 @default.
- W4315705320 creator A5089717747 @default.
- W4315705320 date "2023-02-01" @default.
- W4315705320 modified "2023-10-10" @default.
- W4315705320 title "Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons" @default.
- W4315705320 cites W1031578623 @default.
- W4315705320 cites W1569253487 @default.
- W4315705320 cites W1901618512 @default.
- W4315705320 cites W1964544761 @default.
- W4315705320 cites W1967485833 @default.
- W4315705320 cites W1974452230 @default.
- W4315705320 cites W1981881062 @default.
- W4315705320 cites W1981972209 @default.
- W4315705320 cites W1982882278 @default.
- W4315705320 cites W1985020303 @default.
- W4315705320 cites W1986099885 @default.
- W4315705320 cites W1988432563 @default.
- W4315705320 cites W1989297192 @default.
- W4315705320 cites W1992603067 @default.
- W4315705320 cites W1993359082 @default.
- W4315705320 cites W1994486848 @default.
- W4315705320 cites W1995560608 @default.
- W4315705320 cites W1998446180 @default.
- W4315705320 cites W2008783244 @default.
- W4315705320 cites W2015556811 @default.
- W4315705320 cites W2019195172 @default.
- W4315705320 cites W2019251493 @default.
- W4315705320 cites W2019926289 @default.
- W4315705320 cites W2019962736 @default.
- W4315705320 cites W2021696469 @default.
- W4315705320 cites W2028046413 @default.
- W4315705320 cites W2029667189 @default.
- W4315705320 cites W2030051800 @default.
- W4315705320 cites W2035266068 @default.
- W4315705320 cites W2037220592 @default.
- W4315705320 cites W2040027262 @default.
- W4315705320 cites W2040810212 @default.
- W4315705320 cites W2045295282 @default.
- W4315705320 cites W2049135139 @default.
- W4315705320 cites W2049286183 @default.
- W4315705320 cites W2050395164 @default.
- W4315705320 cites W2050868331 @default.
- W4315705320 cites W2051864856 @default.
- W4315705320 cites W2057477511 @default.
- W4315705320 cites W2059493197 @default.
- W4315705320 cites W2063444896 @default.
- W4315705320 cites W2066523597 @default.
- W4315705320 cites W2067218748 @default.
- W4315705320 cites W2069856608 @default.
- W4315705320 cites W2072163112 @default.
- W4315705320 cites W2073795835 @default.
- W4315705320 cites W2073970540 @default.
- W4315705320 cites W2077007232 @default.
- W4315705320 cites W2079452735 @default.
- W4315705320 cites W2085450663 @default.
- W4315705320 cites W2086771436 @default.
- W4315705320 cites W2087609924 @default.
- W4315705320 cites W2091355622 @default.
- W4315705320 cites W2101687573 @default.
- W4315705320 cites W2103084915 @default.
- W4315705320 cites W2106176161 @default.
- W4315705320 cites W2106639405 @default.
- W4315705320 cites W2112078820 @default.
- W4315705320 cites W2119267663 @default.
- W4315705320 cites W2124024237 @default.
- W4315705320 cites W2126912411 @default.
- W4315705320 cites W2129538319 @default.
- W4315705320 cites W2134208433 @default.
- W4315705320 cites W2139078120 @default.
- W4315705320 cites W2140277725 @default.
- W4315705320 cites W2140898147 @default.
- W4315705320 cites W2144993965 @default.
- W4315705320 cites W2145628385 @default.
- W4315705320 cites W2150807254 @default.
- W4315705320 cites W2151616366 @default.
- W4315705320 cites W2152711232 @default.
- W4315705320 cites W2158217645 @default.
- W4315705320 cites W2160633317 @default.
- W4315705320 cites W2161048544 @default.
- W4315705320 cites W2163668642 @default.
- W4315705320 cites W2167279371 @default.