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- W4315705396 abstract "Over the past almost 30 years the roles of inflammation and later of specific immune cells in the mechanisms of hypertension have increasingly been demonstrated. Initially it was shown that immune cells infiltrated perivascular tissue in the heart and kidney. Later, the demonstration that macrophages and shortly after T lymphocytes were critical for angiotensin II and DOCA-salt-induced hypertension consolidated the idea that immune mechanisms played a role in cardiovascular and renal injury in hypertension. As well, the anti-inflammatory role of T regulatory lymphocytes, the participation of dendritic cells, of gamma/delta T lymphocytes, of neutrophils through the formation of neutrophil extracellular traps (NETs), has become evident. The role of antigen presentation and intracellular mechanisms leading to activation of innate and adaptive immunity in hypertension have offered additional opportunities for eventually targeting the immune system to control inflammation-mediated damage in hypertension. Interferon-gamma and interleukin-17 appear to be important pro-inflammatory cytokines, whereas interleukin-10 plays an anti-inflammatory role in hypertension. Recent application of single cell RNA sequencing has opened novel vistas of the landscape of immune cells participating in cardiovascular and renal injury in hypertension, which can lead to new therapeutic options to control blood pressure and target organ damage in hypertensive patients." @default.
- W4315705396 created "2023-01-12" @default.
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- W4315705396 date "2023-01-01" @default.
- W4315705396 modified "2023-10-02" @default.
- W4315705396 title "S-40-1: INFLAMMATION AND IMMUNITY IN HYPERTENSION" @default.
- W4315705396 doi "https://doi.org/10.1097/01.hjh.0000913592.41308.0b" @default.
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