Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315705554> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4315705554 endingPage "e81" @default.
- W4315705554 startingPage "e81" @default.
- W4315705554 abstract "Beyond the physiological effects of sodium and potassium strong evidence from animal, clinical and epidemiological studies, has implicated excess dietary sodium and low potassium intake as major factors associated with the development of hypertension and increase in stroke risk. Daily salt intake of 5–6 g 85–100 mmol was recommended for the general population i.e. 2.0–2.4 g Na along with K intake to at least 90 mmol d 3.51 g perd. Randomized trials demonstrate that salt reduction and potassium increase in diet lowers blood pressure and reduces the risk of brain damage and cardiovascular disease. Population studies showed that 15 percent reduction of salt intake from 9.5 g/day was associated with a 40 percent reduction of stroke and CHD mortality. Potassium lowers BP via multiple mechanisms, by acting directly on the vasculature and by triggering a signalling cascade mediated by endothelium and also reduces salt-sensitivity. A meta-analysis of 21 RCTs reported that increasing potassium intake lowers BP 3.5/2.0 mm Hg and the risk of stroke. Eating more than 11 g of salt /day was associated with 2.5 times more likely to have a stroke than those who got less than 4.5 g /day. Switching from regular salt to a salt substitute reduced the risk for stroke, major CV events and death in a large trial of adults in rural China with a history of stroke or high risk for stroke. High salt intake reduces resting cerebral blood flow and induces endothelial dysfunction in mice and impairs vasodilatory responses of cerebral vessels. Gut-brain relation links dietary salt to cognitive impairment though a gut-initiated adaptative immune response damaging brain function via increase in circulating IL-17. A high potassium diet reduces cerebral infact size and improves vascular function independently of BP changes. Thus high salt and low potassium intake interfere in multtiple brain vascular strutural complex processes including fluid homeostasis and inflammatory mechanisms, immune responses and gut-microbiome-brain axis." @default.
- W4315705554 created "2023-01-12" @default.
- W4315705554 creator A5070646346 @default.
- W4315705554 date "2023-01-01" @default.
- W4315705554 modified "2023-10-02" @default.
- W4315705554 title "S-36-2: SOCIAL FRAMEWORK TO PROMOTE SALT REDUCTION AND HEALTHY DIETS WITHIN HYPERTENSION AND STROKE PREVENTION" @default.
- W4315705554 doi "https://doi.org/10.1097/01.hjh.0000913496.45534.3c" @default.
- W4315705554 hasPublicationYear "2023" @default.
- W4315705554 type Work @default.
- W4315705554 citedByCount "0" @default.
- W4315705554 crossrefType "journal-article" @default.
- W4315705554 hasAuthorship W4315705554A5070646346 @default.
- W4315705554 hasBestOaLocation W43157055541 @default.
- W4315705554 hasConcept C126322002 @default.
- W4315705554 hasConcept C127413603 @default.
- W4315705554 hasConcept C134018914 @default.
- W4315705554 hasConcept C178790620 @default.
- W4315705554 hasConcept C185592680 @default.
- W4315705554 hasConcept C2780645631 @default.
- W4315705554 hasConcept C2908647359 @default.
- W4315705554 hasConcept C42407357 @default.
- W4315705554 hasConcept C517785266 @default.
- W4315705554 hasConcept C537181965 @default.
- W4315705554 hasConcept C71924100 @default.
- W4315705554 hasConcept C78519656 @default.
- W4315705554 hasConcept C84393581 @default.
- W4315705554 hasConcept C99454951 @default.
- W4315705554 hasConceptScore W4315705554C126322002 @default.
- W4315705554 hasConceptScore W4315705554C127413603 @default.
- W4315705554 hasConceptScore W4315705554C134018914 @default.
- W4315705554 hasConceptScore W4315705554C178790620 @default.
- W4315705554 hasConceptScore W4315705554C185592680 @default.
- W4315705554 hasConceptScore W4315705554C2780645631 @default.
- W4315705554 hasConceptScore W4315705554C2908647359 @default.
- W4315705554 hasConceptScore W4315705554C42407357 @default.
- W4315705554 hasConceptScore W4315705554C517785266 @default.
- W4315705554 hasConceptScore W4315705554C537181965 @default.
- W4315705554 hasConceptScore W4315705554C71924100 @default.
- W4315705554 hasConceptScore W4315705554C78519656 @default.
- W4315705554 hasConceptScore W4315705554C84393581 @default.
- W4315705554 hasConceptScore W4315705554C99454951 @default.
- W4315705554 hasIssue "Suppl 1" @default.
- W4315705554 hasLocation W43157055541 @default.
- W4315705554 hasLocation W43157055542 @default.
- W4315705554 hasOpenAccess W4315705554 @default.
- W4315705554 hasPrimaryLocation W43157055541 @default.
- W4315705554 hasRelatedWork W1966504330 @default.
- W4315705554 hasRelatedWork W1968079039 @default.
- W4315705554 hasRelatedWork W1979139803 @default.
- W4315705554 hasRelatedWork W2006202112 @default.
- W4315705554 hasRelatedWork W2031880155 @default.
- W4315705554 hasRelatedWork W2037631372 @default.
- W4315705554 hasRelatedWork W2040058909 @default.
- W4315705554 hasRelatedWork W2132898409 @default.
- W4315705554 hasRelatedWork W2470574787 @default.
- W4315705554 hasRelatedWork W2748952813 @default.
- W4315705554 hasVolume "41" @default.
- W4315705554 isParatext "false" @default.
- W4315705554 isRetracted "false" @default.
- W4315705554 workType "article" @default.