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- W4315705588 abstract "Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is the most common form of noninfectious intraocular inflammation and is considered to be a separate clinical entity. Young adults between the ages of 20 and 40 years are predominantly affected. The HLA-B27 positive AAU typically presents as a unilateral, fulminant disruption of the blood-aqueous humor barrier, which is accompanied by pronounced cellular infiltration and fibrinous exudation. Other characteristics are reduced intraocular pressure and a high tendency to relapse, which can also involve the partner eye. Patients with HLA-B27 positive AAU share a high risk for other genetically associated diseases, especially spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% of those affected have a systemic disease that has not yet been diagnosed, the ophthalmologist is of major importance for early detection.Die mit dem humanen Leukozytenantigen(HLA)-B27 assoziierte, akute anteriore Uveitis (AAU) ist die häufigste Form nichtinfektiöser intraokulärer Entzündungen und wird als eigene klinische Entität gesehen. Es sind überwiegend junge Erwachsene im Alter zwischen 20 und 40 Jahren betroffen. Die HLA-B27-positive AAU präsentiert sich typischerweise als einseitige, fulminante Störung der Blut-Kammerwasser-Schranke, die mit einer ausgeprägten zellulären Infiltration und fibrinösen Exsudation einhergeht. Weitere Charakteristika sind ein verminderter Augeninnendruck und eine hohe Rezidivneigung, die auch das 2. Auge einbeziehen kann. Patienten mit HLA-B27-positiver AAU teilen ein hohes Risiko zu weiteren genetisch assoziierten Erkrankungen, insbesondere zu Spondyloarthritis, chronischer Darmerkrankung und Psoriasis. Da bei bis zu 40 % der Betroffenen eine bisher nicht diagnostizierte Systemerkrankung vorliegt, kommt dem Ophthalmologen eine wichtige Bedeutung bei der Früherkennung zu." @default.
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- W4315705588 date "2023-01-01" @default.
- W4315705588 modified "2023-10-07" @default.
- W4315705588 title "HLA-B27-positive Uveitis anterior" @default.
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- W4315705588 doi "https://doi.org/10.1007/s00347-022-01793-2" @default.
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