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- W4315705949 abstract "Recent studies at individual cell resolution have revealed phenotypic heterogeneity in nominally clonal tumor cell populations. The heterogeneity affects cell growth behaviors, which can result in departure from the idealized exponential growth. Here we measured the stochastic time courses of growth of an ensemble of populations of HL60 leukemia cells in cultures, starting with distinct initial cell numbers to capture the departure from the exponential growth model in the initial growth phase. Despite being derived from the same cell clone, we observed significant variations in the early growth patterns of individual cultures with statistically significant differences in growth kinetics and the presence of subpopulations with different growth rates that endured for many generations. Based on the hypothesis of existence of multiple inter-converting subpopulations, we developed a branching process model that captures the experimental observations." @default.
- W4315705949 created "2023-01-12" @default.
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- W4315705949 date "2023-01-09" @default.
- W4315705949 modified "2023-09-29" @default.
- W4315705949 title "Multiple phenotypes in HL60 leukemia cell population" @default.
- W4315705949 doi "https://doi.org/10.48550/arxiv.2301.03782" @default.
- W4315705949 hasPublicationYear "2023" @default.
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