FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315706419> ?p ?o ?g. }

• W4315706419 endingPage "F244" @default.
• W4315706419 startingPage "F227" @default.
• W4315706419 abstract "Mg2+ is essential for many cellular and physiological processes, including muscle contraction, neuronal activity, and metabolism. Consequently, the blood Mg2+ concentration is tightly regulated by balanced intestinal Mg2+ absorption, renal Mg2+ excretion, and Mg2+ storage in bone and soft tissues. In recent years, the development of novel transgenic animal models and identification of Mendelian disorders has advanced our current insight in the molecular mechanisms of Mg2+ reabsorption in the kidney. In the proximal tubule, Mg2+ reabsorption is dependent on paracellular permeability by claudin-2/12. In the thick ascending limb of Henle's loop, the claudin-16/19 complex provides a cation-selective pore for paracellular Mg2+ reabsorption. The paracellular Mg2+ reabsorption in this segment is regulated by the Ca2+-sensing receptor, parathyroid hormone, and mechanistic target of rapamycin (mTOR) signaling. In the distal convoluted tubule, the fine tuning of Mg2+ reabsorption takes place by transcellular Mg2+ reabsorption via transient receptor potential melastatin-like types 6 and 7 (TRPM6/TRPM7) divalent cation channels. Activity of TRPM6/TRPM7 is dependent on hormonal regulation, metabolic activity, and interacting proteins. Basolateral Mg2+ extrusion is still poorly understood but is probably dependent on the Na+ gradient. Cyclin M2 and SLC41A3 are the main candidates to act as Na+/Mg2+ exchangers. Consequently, disturbances of basolateral Na+/K+ transport indirectly result in impaired renal Mg2+ reabsorption in the distal convoluted tubule. Altogether, this review aims to provide an overview of the molecular mechanisms of Mg2+ reabsorption in the kidney, specifically focusing on transgenic mouse models and human hereditary diseases." @default.
• W4315706419 created "2023-01-12" @default.
• W4315706419 creator A5015213562 @default.
• W4315706419 date "2023-03-01" @default.
• W4315706419 modified "2023-10-13" @default.
• W4315706419 title "Magnesium reabsorption in the kidney" @default.
• W4315706419 cites W1531491702 @default.
• W4315706419 cites W1604605338 @default.
• W4315706419 cites W1857677349 @default.
• W4315706419 cites W1877998438 @default.
• W4315706419 cites W1907852797 @default.
• W4315706419 cites W1921602963 @default.
• W4315706419 cites W1968572877 @default.
• W4315706419 cites W1969722725 @default.
• W4315706419 cites W1970486445 @default.
• W4315706419 cites W1971137608 @default.
• W4315706419 cites W1971877828 @default.
• W4315706419 cites W1974426390 @default.
• W4315706419 cites W1974489700 @default.
• W4315706419 cites W1974553541 @default.
• W4315706419 cites W1981688857 @default.
• W4315706419 cites W1982944575 @default.
• W4315706419 cites W1985131786 @default.
• W4315706419 cites W1985793100 @default.
• W4315706419 cites W1988301438 @default.
• W4315706419 cites W1993207947 @default.
• W4315706419 cites W1998631230 @default.
• W4315706419 cites W2000476721 @default.
• W4315706419 cites W2000936082 @default.
• W4315706419 cites W2009099990 @default.
• W4315706419 cites W2009455555 @default.
• W4315706419 cites W2011414076 @default.
• W4315706419 cites W2015392008 @default.
• W4315706419 cites W2023410200 @default.
• W4315706419 cites W2025655555 @default.
• W4315706419 cites W2027293217 @default.
• W4315706419 cites W2028652849 @default.
• W4315706419 cites W2034675173 @default.
• W4315706419 cites W2038902966 @default.
• W4315706419 cites W2039092096 @default.
• W4315706419 cites W2039492547 @default.
• W4315706419 cites W2040814486 @default.
• W4315706419 cites W2044000445 @default.
• W4315706419 cites W2045317854 @default.
• W4315706419 cites W2045533437 @default.
• W4315706419 cites W2047640546 @default.
• W4315706419 cites W2048988573 @default.
• W4315706419 cites W2053274457 @default.
• W4315706419 cites W2055961155 @default.
• W4315706419 cites W2062703082 @default.
• W4315706419 cites W2065341014 @default.
• W4315706419 cites W2066031126 @default.
• W4315706419 cites W2067549328 @default.
• W4315706419 cites W2068119388 @default.
• W4315706419 cites W2072135863 @default.
• W4315706419 cites W2074534151 @default.
• W4315706419 cites W2075554293 @default.
• W4315706419 cites W2075695348 @default.
• W4315706419 cites W2077899564 @default.
• W4315706419 cites W2078726241 @default.
• W4315706419 cites W2081144498 @default.
• W4315706419 cites W2082379191 @default.
• W4315706419 cites W2083381858 @default.
• W4315706419 cites W2085365282 @default.
• W4315706419 cites W2087429403 @default.
• W4315706419 cites W2087482733 @default.
• W4315706419 cites W2091422963 @default.
• W4315706419 cites W2095491329 @default.
• W4315706419 cites W2097799706 @default.
• W4315706419 cites W2100194579 @default.
• W4315706419 cites W2101937063 @default.
• W4315706419 cites W2102728230 @default.
• W4315706419 cites W2104529068 @default.
• W4315706419 cites W2111392032 @default.
• W4315706419 cites W2111599410 @default.
• W4315706419 cites W2114814810 @default.
• W4315706419 cites W2115090138 @default.
• W4315706419 cites W2117029407 @default.
• W4315706419 cites W2117847991 @default.
• W4315706419 cites W2117993382 @default.
• W4315706419 cites W2118228561 @default.
• W4315706419 cites W2119560251 @default.
• W4315706419 cites W2119843247 @default.
• W4315706419 cites W2122657164 @default.
• W4315706419 cites W2123906214 @default.
• W4315706419 cites W2124124332 @default.
• W4315706419 cites W2125116769 @default.
• W4315706419 cites W2125269793 @default.
• W4315706419 cites W2135394966 @default.
• W4315706419 cites W2135831174 @default.
• W4315706419 cites W2135910910 @default.
• W4315706419 cites W2138111460 @default.
• W4315706419 cites W2139228286 @default.
• W4315706419 cites W2140388790 @default.
• W4315706419 cites W2141341223 @default.
• W4315706419 cites W2141790142 @default.
• W4315706419 cites W2142766228 @default.
• W4315706419 cites W2142980147 @default.

• next