FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315706989> ?p ?o ?g. }

• W4315706989 endingPage "154251" @default.
• W4315706989 startingPage "154251" @default.
• W4315706989 abstract "Volatile anesthetics are used more commonly for sedation in the intensive-care-unit (ICU). However, evidence for long-term use remains low. We therefore conducted a randomized-controlled trial comparing sevoflurane with intravenous sedation with particular focus on efficacy and safety. In this prospective, randomized-controlled phase-IIb monocentric clinical-trial ICU patients requiring at least 48 h of sedation were randomized to receive sevoflurane (S) or propofol/midazolam (P). Sedation quality was monitored using the Richmond-Agitation-Sedation-Scale. Following termination of sedation, the time to spontaneous breathing and extubation, opioid consumption, hemodynamics, ICU and hospital length of stay (LOS) and adverse events were recorded. 79 patients were eligible to randomization. Sedation quality was comparable between sevoflurane (n = 39) and propofol (n = 40). However, the use of sevoflurane lead to a reduction in time to spontaneous breathing (26 min vs. 375 min, P < 0.001). Patients sedated with propofol had lower opioid requirements (remifentanil:400 μg/h vs. 500 μg/h, P = 0.007; sufentanil:40 μg/h vs. 30 μg/h, P = 0.007) while hemodynamics, LOS or the occurrence of adverse events did not differ. ICU patients sedated with sevoflurane >48 h may return to spontaneous breathing faster, while the quality of sedation is comparable to a propofol-based sedation regime. Sevoflurane might be considered to be safe for long-term sedation in this patient population, while being non-inferior compared to propofol." @default.
• W4315706989 created "2023-01-12" @default.
• W4315706989 creator A5039384359 @default.
• W4315706989 creator A5064328224 @default.
• W4315706989 creator A5066315931 @default.
• W4315706989 creator A5072025434 @default.
• W4315706989 creator A5074469834 @default.
• W4315706989 creator A5089750219 @default.
• W4315706989 date "2023-04-01" @default.
• W4315706989 modified "2023-09-30" @default.
• W4315706989 title "Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial" @default.
• W4315706989 cites W1963561043 @default.
• W4315706989 cites W2010207161 @default.
• W4315706989 cites W2020891266 @default.
• W4315706989 cites W2022361338 @default.
• W4315706989 cites W2033757349 @default.
• W4315706989 cites W2041441379 @default.
• W4315706989 cites W2055475141 @default.
• W4315706989 cites W2073842830 @default.
• W4315706989 cites W2102347034 @default.
• W4315706989 cites W2107778752 @default.
• W4315706989 cites W2127709547 @default.
• W4315706989 cites W2130271602 @default.
• W4315706989 cites W2135644717 @default.
• W4315706989 cites W2139146091 @default.
• W4315706989 cites W2160441467 @default.
• W4315706989 cites W2160535600 @default.
• W4315706989 cites W2162909827 @default.
• W4315706989 cites W2512780017 @default.
• W4315706989 cites W2545066822 @default.
• W4315706989 cites W2555737777 @default.
• W4315706989 cites W2604006406 @default.
• W4315706989 cites W2771793086 @default.
• W4315706989 cites W2773054631 @default.
• W4315706989 cites W2791475499 @default.
• W4315706989 cites W2883218545 @default.
• W4315706989 cites W2886033986 @default.
• W4315706989 cites W2910285749 @default.
• W4315706989 cites W3087474709 @default.
• W4315706989 cites W3110024302 @default.
• W4315706989 cites W3121123820 @default.
• W4315706989 cites W3175681906 @default.
• W4315706989 cites W3195497415 @default.
• W4315706989 cites W79015887 @default.
• W4315706989 doi "https://doi.org/10.1016/j.jcrc.2022.154251" @default.
• W4315706989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640476" @default.
• W4315706989 hasPublicationYear "2023" @default.
• W4315706989 type Work @default.
• W4315706989 citedByCount "2" @default.
• W4315706989 countsByYear W43157069892023 @default.
• W4315706989 crossrefType "journal-article" @default.
• W4315706989 hasAuthorship W4315706989A5039384359 @default.
• W4315706989 hasAuthorship W4315706989A5064328224 @default.
• W4315706989 hasAuthorship W4315706989A5066315931 @default.
• W4315706989 hasAuthorship W4315706989A5072025434 @default.
• W4315706989 hasAuthorship W4315706989A5074469834 @default.
• W4315706989 hasAuthorship W4315706989A5089750219 @default.
• W4315706989 hasBestOaLocation W43157069891 @default.
• W4315706989 hasConcept C126322002 @default.
• W4315706989 hasConcept C141071460 @default.
• W4315706989 hasConcept C168563851 @default.
• W4315706989 hasConcept C177713679 @default.
• W4315706989 hasConcept C197934379 @default.
• W4315706989 hasConcept C2776277131 @default.
• W4315706989 hasConcept C2776376669 @default.
• W4315706989 hasConcept C2776814716 @default.
• W4315706989 hasConcept C2777019824 @default.
• W4315706989 hasConcept C2777080012 @default.
• W4315706989 hasConcept C2777602617 @default.
• W4315706989 hasConcept C2778000748 @default.
• W4315706989 hasConcept C2778891214 @default.
• W4315706989 hasConcept C2781453256 @default.
• W4315706989 hasConcept C42219234 @default.
• W4315706989 hasConcept C71924100 @default.
• W4315706989 hasConceptScore W4315706989C126322002 @default.
• W4315706989 hasConceptScore W4315706989C141071460 @default.
• W4315706989 hasConceptScore W4315706989C168563851 @default.
• W4315706989 hasConceptScore W4315706989C177713679 @default.
• W4315706989 hasConceptScore W4315706989C197934379 @default.
• W4315706989 hasConceptScore W4315706989C2776277131 @default.
• W4315706989 hasConceptScore W4315706989C2776376669 @default.
• W4315706989 hasConceptScore W4315706989C2776814716 @default.
• W4315706989 hasConceptScore W4315706989C2777019824 @default.
• W4315706989 hasConceptScore W4315706989C2777080012 @default.
• W4315706989 hasConceptScore W4315706989C2777602617 @default.
• W4315706989 hasConceptScore W4315706989C2778000748 @default.
• W4315706989 hasConceptScore W4315706989C2778891214 @default.
• W4315706989 hasConceptScore W4315706989C2781453256 @default.
• W4315706989 hasConceptScore W4315706989C42219234 @default.
• W4315706989 hasConceptScore W4315706989C71924100 @default.
• W4315706989 hasLocation W43157069891 @default.
• W4315706989 hasLocation W43157069892 @default.
• W4315706989 hasOpenAccess W4315706989 @default.
• W4315706989 hasPrimaryLocation W43157069891 @default.
• W4315706989 hasRelatedWork W2027741645 @default.
• W4315706989 hasRelatedWork W2034242176 @default.
• W4315706989 hasRelatedWork W2124545707 @default.
• W4315706989 hasRelatedWork W2139146091 @default.

• next