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- W4315707026 abstract "Objective: Cognitive impairment is disorder that can arise as a result of cardiovascular pathology or cerebrovascular injury. Due to the aging population, the incidence of cognitive impairment is expected to rise. Hypertension is a major risk factor for stroke and cognitive impairment, but it is unclear whether it may affect post-stroke cognitive outcomes. This study aims to assess the effects of hypertension and/or stroke on the brain and its effect on cognitive impairment. Design and method: C57BL/6J mice (n = 117) aged 3–5 months received infusion of either saline or angiotensin II (0.7 mg/kg/day for 14d or 0.28 mg/kg/day for 28d). 7 d after minipump implantation mice received either sham or photothrombotic stroke surgery targeting the prefrontal cortex. The Barnes maze was utilised to assess cognitive function. RNA sequencing was used to quantify transcriptomic changes in the brain. Results: Angiotensin II increased blood pressure (normotensive: 118 ± 1 mmHg vs. hypertensive: 149 ± 2 mmHg; P < 0.05). In the Barnes maze, hypertensive mice that received stroke surgery had increased latency to enter the escape hole when compared to other groups (day 3 escape latency: hypertensive + stroke = 166.6 ± 6.0 s vs. hypertensive + sham = 122.8 ± 13.8 s vs. normotensive + stroke = 139.9 ± 10.1 s vs. normotensive + sham = 101.9 ± 16.7 s), consistent with a greater learning impairment. Interestingly, we observed 5 incidences of haemorrhage within the HT + stroke group. RNA sequencing revealed > 1500 differentially expressed genes in hypertensive + stroke vs. hypertensive + sham, including genes related to inflammation and synaptic function. Conclusions: These findings indicate that the combination of hypertension and stroke resulted in greater learning impairment and brain injury. If transferrable to humans, the present data suggest that therapeutic approaches to effectively treat hypertension are likely to mitigate worsened post-stroke cognitive outcomes." @default.
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- W4315707026 date "2023-01-01" @default.
- W4315707026 modified "2023-10-03" @default.
- W4315707026 title "PS-B10-3: POST-STROKE LEARNING IMPAIRMENT IS AUGMENTED IN HYPERTENSIVE MICE" @default.
- W4315707026 doi "https://doi.org/10.1097/01.hjh.0000917420.09992.19" @default.
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