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- W4315709065 abstract "Stimulator of interferon genes (STING) signaling has been extensively studied in inflammatory diseases and cancer, while its role in T cell responses to infection is unclear. Using Listeria monocytogenes strains engineered to induce different levels of c-di-AMP, we found that high STING signals impaired T cell memory upon infection via increased Bim levels and apoptosis. Unexpectedly, reduction of TCR signal strength or T cell-STING expression decreased Bim expression, T cell apoptosis, and recovered T cell memory. We found that TCR signal intensity coupled STING signal strength to the unfolded protein response (UPR) and T cell survival. Under strong STING signaling, Indoleamine-pyrrole 2,3-dioxygenase (IDO) inhibition also reduced apoptosis and led to a recovery of T cell memory in STING sufficient CD8 T cells. Thus, STING signaling regulates CD8 T cell memory fitness through both cell-intrinsic and extrinsic mechanisms. These studies provide insight into how IDO and STING therapies could improve long-term T cell protective immunity." @default.
- W4315709065 created "2023-01-12" @default.
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- W4315709065 date "2023-01-12" @default.
- W4315709065 modified "2023-09-23" @default.
- W4315709065 title "STING controls T cell memory fitness during infection through T cell-intrinsic and IDO-dependent mechanisms" @default.
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- W4315709065 doi "https://doi.org/10.1073/pnas.2205049120" @default.
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- W4315709065 hasPublicationYear "2023" @default.
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