Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315709214> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4315709214 abstract "<p>Increased saturated fatty acid levels in membrane phospholipids have been implicated in the development of metabolic disease. Here, we tested the hypothesis that increased saturated fatty acid (SFA) content in cell membranes negatively impacts adipocyte insulin signaling. Pre-adipocyte cell models with elevated SFA levels in phospholipids were generated by disrupting the <em>ADIPOR2</em> locus, which resulted in a striking two-fold increase in SFA-containing phosphatidylcholines and phosphatidylethanolamines, which persisted in differentiated adipocytes. Similar changes in phospholipid composition were observed in white adipose tissues isolated from the ADIPOR2 knockout mice. The SFA levels in phospholipids could be further increased by treating <em>ADIPOR2</em>-deficient cells with palmitic acid and resulted in reduced membrane fluidity and endoplasmic reticulum stress in mouse and human pre-adipocytes. Strikingly, increased SFA levels in differentiated adipocyte phospholipids had no effect on adipocyte gene expression or insulin signaling <em>in vitro</em>. Similarly, increased adipocyte phospholipid saturation did not impair white adipose tissue function <em>in vivo</em>, even in mice fed a high saturated fat diet at thermoneutrality. We conclude that increasing SFA levels in adipocyte phospholipids is well tolerated and does not affect adipocyte insulin signaling <em>in vitro</em> and <em>in vivo</em>.</p>" @default.
- W4315709214 created "2023-01-12" @default.
- W4315709214 creator A5011756139 @default.
- W4315709214 creator A5012885402 @default.
- W4315709214 creator A5016064806 @default.
- W4315709214 creator A5016385816 @default.
- W4315709214 creator A5024366362 @default.
- W4315709214 creator A5026711091 @default.
- W4315709214 creator A5027598060 @default.
- W4315709214 creator A5028629304 @default.
- W4315709214 creator A5034670957 @default.
- W4315709214 creator A5035761279 @default.
- W4315709214 creator A5038296609 @default.
- W4315709214 creator A5041038982 @default.
- W4315709214 creator A5051621776 @default.
- W4315709214 creator A5051677373 @default.
- W4315709214 creator A5058873811 @default.
- W4315709214 creator A5067284329 @default.
- W4315709214 creator A5070282117 @default.
- W4315709214 creator A5072973682 @default.
- W4315709214 creator A5075072986 @default.
- W4315709214 creator A5080445805 @default.
- W4315709214 date "2023-01-12" @default.
- W4315709214 modified "2023-09-27" @default.
- W4315709214 title "ELEVATED ADIPOCYTE MEMBRANE PHOSPHOLIPID SATURATION DOES NOT COMPROMISE INSULIN SIGNALING" @default.
- W4315709214 doi "https://doi.org/10.2337/figshare.21782726.v2" @default.
- W4315709214 hasPublicationYear "2023" @default.
- W4315709214 type Work @default.
- W4315709214 citedByCount "0" @default.
- W4315709214 crossrefType "posted-content" @default.
- W4315709214 hasAuthorship W4315709214A5011756139 @default.
- W4315709214 hasAuthorship W4315709214A5012885402 @default.
- W4315709214 hasAuthorship W4315709214A5016064806 @default.
- W4315709214 hasAuthorship W4315709214A5016385816 @default.
- W4315709214 hasAuthorship W4315709214A5024366362 @default.
- W4315709214 hasAuthorship W4315709214A5026711091 @default.
- W4315709214 hasAuthorship W4315709214A5027598060 @default.
- W4315709214 hasAuthorship W4315709214A5028629304 @default.
- W4315709214 hasAuthorship W4315709214A5034670957 @default.
- W4315709214 hasAuthorship W4315709214A5035761279 @default.
- W4315709214 hasAuthorship W4315709214A5038296609 @default.
- W4315709214 hasAuthorship W4315709214A5041038982 @default.
- W4315709214 hasAuthorship W4315709214A5051621776 @default.
- W4315709214 hasAuthorship W4315709214A5051677373 @default.
- W4315709214 hasAuthorship W4315709214A5058873811 @default.
- W4315709214 hasAuthorship W4315709214A5067284329 @default.
- W4315709214 hasAuthorship W4315709214A5070282117 @default.
- W4315709214 hasAuthorship W4315709214A5072973682 @default.
- W4315709214 hasAuthorship W4315709214A5075072986 @default.
- W4315709214 hasAuthorship W4315709214A5080445805 @default.
- W4315709214 hasBestOaLocation W43157092141 @default.
- W4315709214 hasConcept C126322002 @default.
- W4315709214 hasConcept C134018914 @default.
- W4315709214 hasConcept C151955695 @default.
- W4315709214 hasConcept C171089720 @default.
- W4315709214 hasConcept C185592680 @default.
- W4315709214 hasConcept C2776175234 @default.
- W4315709214 hasConcept C2778918659 @default.
- W4315709214 hasConcept C41625074 @default.
- W4315709214 hasConcept C55493867 @default.
- W4315709214 hasConcept C71924100 @default.
- W4315709214 hasConcept C86803240 @default.
- W4315709214 hasConceptScore W4315709214C126322002 @default.
- W4315709214 hasConceptScore W4315709214C134018914 @default.
- W4315709214 hasConceptScore W4315709214C151955695 @default.
- W4315709214 hasConceptScore W4315709214C171089720 @default.
- W4315709214 hasConceptScore W4315709214C185592680 @default.
- W4315709214 hasConceptScore W4315709214C2776175234 @default.
- W4315709214 hasConceptScore W4315709214C2778918659 @default.
- W4315709214 hasConceptScore W4315709214C41625074 @default.
- W4315709214 hasConceptScore W4315709214C55493867 @default.
- W4315709214 hasConceptScore W4315709214C71924100 @default.
- W4315709214 hasConceptScore W4315709214C86803240 @default.
- W4315709214 hasLocation W43157092141 @default.
- W4315709214 hasLocation W43157092142 @default.
- W4315709214 hasOpenAccess W4315709214 @default.
- W4315709214 hasPrimaryLocation W43157092141 @default.
- W4315709214 hasRelatedWork W1979647427 @default.
- W4315709214 hasRelatedWork W1992021892 @default.
- W4315709214 hasRelatedWork W1996584884 @default.
- W4315709214 hasRelatedWork W2008100038 @default.
- W4315709214 hasRelatedWork W2008460293 @default.
- W4315709214 hasRelatedWork W2011657070 @default.
- W4315709214 hasRelatedWork W2027098794 @default.
- W4315709214 hasRelatedWork W2071007699 @default.
- W4315709214 hasRelatedWork W2118746168 @default.
- W4315709214 hasRelatedWork W2228231544 @default.
- W4315709214 isParatext "false" @default.
- W4315709214 isRetracted "false" @default.
- W4315709214 workType "article" @default.