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• W4315709545 endingPage "e3001647" @default.
• W4315709545 startingPage "e3001647" @default.
• W4315709545 abstract "The oral microbiome is second only to its intestinal counterpart in diversity and abundance, but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found that mouse taste cells, in particular, sweet and umami receptor cells that express taste 1 receptor member 3 (Tas1r3), have a gene expression signature reminiscent of Microfold (M) cells, a central player in immune surveillance in the mucosa-associated lymphoid tissue (MALT) such as those in the Peyer's patch and tonsils. Administration of tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known as RANKL), a growth factor required for differentiation of M cells, dramatically increased M cell proliferation and marker gene expression in the taste papillae and in cultured taste organoids from wild-type (WT) mice. Taste papillae and organoids from knockout mice lacking Spib (SpibKO), a RANKL-regulated transcription factor required for M cell development and regeneration on the other hand, failed to respond to RANKL. Taste papillae from SpibKO mice also showed reduced expression of NF-κB signaling pathway components and proinflammatory cytokines and attracted fewer immune cells. However, lipopolysaccharide-induced expression of cytokines was strongly up-regulated in SpibKO mice compared to their WT counterparts. Like M cells, taste cells from WT but not SpibKO mice readily took up fluorescently labeled microbeads, a proxy for microbial transcytosis. The proportion of taste cell subtypes are unaltered in SpibKO mice; however, they displayed increased attraction to sweet and umami taste stimuli. We propose that taste cells are involved in immune surveillance and may tune their taste responses to microbial signaling and infection." @default.
• W4315709545 created "2023-01-12" @default.
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• W4315709545 date "2023-01-12" @default.
• W4315709545 modified "2023-10-01" @default.
• W4315709545 title "Type II taste cells participate in mucosal immune surveillance" @default.
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• W4315709545 doi "https://doi.org/10.1371/journal.pbio.3001647" @default.
• W4315709545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634039" @default.
• W4315709545 hasPublicationYear "2023" @default.
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