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• W4315752304 abstract "In metazoans, Polo Kinase (Plk1) controls several mitotic events including nuclear envelope breakdown, centrosome maturation and kinetochore assembly. Here we show that mitotic events regulated by Polo Like Kinase (PLK-1) in early C. elegans embryos depend on the mitochondrial-localized protein SPD-3. spd-3 mutant one-cell embryos contain abnormally positioned mitotic chromosomes and prematurely and asymmetrically disassemble the nuclear lamina. Nuclear envelope breakdown (NEBD) in C. elegans requires direct dephosphorylation of lamin by PLK-1. In spd-3 mutants PLK-1 levels are ~6X higher in comparison to control embryos and PLK-1::GFP was highly accumulated at centrosomes, the nuclear envelope, nucleoplasm, and chromosomes prior to NEBD. Partial depletion of plk-1 in spd-3 mutant embryos rescued mitotic chromosome and spindle positioning defects indicating that these phenotypes result from higher PLK-1 levels and thus activity. Our data suggests that the mitochondrial SPD-3 protein controls NEBD and chromosome positioning by regulating the endogenous levels of PLK-1 during early embryogenesis in C. elegans . This finding suggests a novel link between mitochondria and mitotic events by controlling the amount of a key mitotic regulator, PLK-1 and thus may have further implications in the context of cancers or age-related diseases and infertility as it provides a novel link between mitochondria and mitosis." @default.
• W4315752304 created "2023-01-13" @default.
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• W4315752304 date "2023-01-12" @default.
• W4315752304 modified "2023-10-18" @default.
• W4315752304 title "Mitotic events depend on regulation of PLK-1 levels by the mitochondrial protein SPD-3" @default.
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• W4315752304 doi "https://doi.org/10.1101/2023.01.11.523633" @default.
• W4315752304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36711457" @default.
• W4315752304 hasPublicationYear "2023" @default.
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